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View Structure Prediction Details

Protein: skn-1
Organism: Caenorhabditis elegans
Length: 533 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for skn-1.

Description E-value Query
Range
Subject
Range
skn-1 - status:Confirmed UniProt:P34707 protein_id:AAA83594.2
314.0 [0..1] [533..91]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTDSNNRNF DEVNHQHQQE QDFNGQSKYD YPQFNRPMGL RWRDDQRMME YFMSNGPVET  60
   61 VPVMPILTEH PPASPFGRGP STERPTTSSR YEY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPSLEDIDL IDVLWRSDIA GEKGTRQVAP ADQYECDLQT LTEKSTVAPL TAEENARYED  60
   61 LSKGFYNGFF ESFNNNQYQQ KHQQQQREQI KTPTLEHPTQ KAELEDDLFD EDLAQLFEDV 120
  121 SREEGQLNQL FDNKQQHPVI NNVSLSEGIV YNQAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEMQEMRDS CNQVSISTIP TTSTAQPETL FNVTDSQTVE QWLPTEVVPN DVFPTSNYAY  60
   61 IGMQNDSLQA VVSNGQIDYD HSYQSTGQTP LSPLIIGSSG RQQQTQTSPG SVTVTATATQ 120
  121 SLFDPYHSQR HSFSDCTTDS SSTCSRLSSE SPRYTSESST GTHESRFYGK LAPSSGSRYQ 180
  181 RSSSPRSSQS SIKIARVVPL A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [450-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQRKRGRQS KDEQLASDNE LPVSAFQISE MSLSELQQVL KNESLSEYQR QLIRKIRRRG  60
   61 KNKVAARTCR QRRTDRHDKM SHYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1sknP
Description: Skn-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56528092116191 bayes_pls_golite062009
DNA binding 4.39236205038451 bayes_pls_golite062009
nucleic acid binding 4.27517034548789 bayes_pls_golite062009
transcription factor activity 3.86034396858961 bayes_pls_golite062009
binding 3.28937567198027 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.80824533696213 bayes_pls_golite062009
transcription activator activity 2.80670414213103 bayes_pls_golite062009
protein heterodimerization activity 1.87549895714075 bayes_pls_golite062009
protein dimerization activity 1.4553301455216 bayes_pls_golite062009
sequence-specific DNA binding 1.12585390480455 bayes_pls_golite062009
transcription factor binding 0.495155180229128 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle