YRC Public Data Repository - Protein Structure Prediction

Protein:	AGAY_ECOLI
Organism:	Escherichia coli
Length:	286 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AGAY_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77995172, gi\|... - gi\|78043057\|ref\|YP_359000.1\| putative aldolase [Carboxydothermus hydrogenoformans Z-2901], gi\|779951...	408.0	[0..1]	[284..1]
gi\|89211620, gi\|... - gi\|89211620\|ref\|ZP_01189975.1\| Ketose-bisphosphate aldolase, class-II:Fructose-1,6-bisphosphate aldo...	406.0	[0..1]	[284..1]
gi\|219541095, gi... - gi\|219670835\|ref\|YP_002461270.1\| fructose-1,6-bisphosphate aldolase, class II [Desulfitobacterium ha...	399.0	[0..1]	[284..1]
gi\|49235160, gi\|... - gi\|83591220\|ref\|YP_431229.1\| fructose-1,6-bisphosphate aldolase [Moorella thermoacetica ATCC 39073],...	397.0	[0..1]	[283..1]
gi\|111618272, gi... - gi\|111618272\|ref\|ZP_01405296.1\| ketose-bisphosphate aldolases:Fructose-bisphosphate aldolase, class ...	395.0	[0..1]	[283..625]
gi\|20806666 - gi\|20806666\|ref\|NP_621837.1\| Fructose/tagatose bisphosphate aldolase [Thermoanaerobacter tengcongens... gi\|20806666, gi\|... - gi\|20806666\|ref\|NP_621837.1\| putative aldolase [Thermoanaerobacter tengcongensis MB4], gi\|20515116\|g...	395.0	[0..3]	[284..2]
gi\|56381763, gi\|... - gi\|56421921\|ref\|YP_149239.1\| fructose-bisphosphate aldolase [Geobacillus kaustophilus HTA426], gi\|56... gi\|229497815, gi... - gi\|229497815\|ref\|ZP_04391514.1\| fructose-1,6-bisphosphate aldolase, class II [Geobacillus sp. Y412MC... gi\|221087046, gi... - gi\|221087046\|ref\|ZP_03556586.1\| fructose-1,6-bisphosphate aldolase, class II [Geobacillus sp. Y412MC...	395.0	[0..1]	[285..1]
gi\|114567917, gi... - gi\|71542407\|ref\|ZP_00664018.1\| Ketose-bisphosphate aldolase, class-II:Fructose-1,6-bisphosphate aldo...	394.0	[0..1]	[284..1]
ALF_GEOSE - Fructose-bisphosphate aldolase OS=Geobacillus stearothermophilus GN=fba PE=3 SV=3	394.0	[0..1]	[285..1]
gi\|46915257, gi\|... - gi\|54301837\|ref\|YP_131830.1\| tagatose 1,6-diphosphate aldolase [Photobacterium profundum SS9], gi\|46...	392.0	[0..1]	[284..5]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIISTKYLL QDAQANGYAV PAFNIHNAET IQAILEVCSE MRSPVILAGT PGTFKHIALE  60
   61 EIYALCSAYS TTYNMPLALH LDHHESLDDI RRKVHAGVRS AMIDGSHFPF AENVKLVKSV 120
  121 VDFCHSQDCS VEAELGRLGG VEDDMSVDAE SAFLTDPQEA KRFVELTGVD SLAVAIGTAH 180
  181 GLYSKTPKID FQRLAEIREV VDVPLVLHGA SDVPDEFVRR TIELGVTKVN VATELKIAFA 240
  241 GAVKAWFAEN PQGNDPRYYM RVGMDAMKEV VRNKINVCGS ANRISA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	107.0
Match:	1gvfA
Description:	Tagatose-1,6-bisphosphate aldolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.67031204377352	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	1.88386308805564	bayes_pls_golite062009
transaldolase activity	1.66628808988861	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	1.38491877751839	bayes_pls_golite062009
aldehyde-lyase activity	0.351872954170322	bayes_pls_golite062009
binding	0.300492369985193	bayes_pls_golite062009
signal transducer activity	0.206436778535918	bayes_pls_golite062009
molecular transducer activity	0.206436778535918	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: