YRC Public Data Repository - Protein Structure Prediction

Protein:	CUER_ECOLI
Organism:	Escherichia coli
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUER_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|17430370 - gi\|17430370\|emb\|CAD17135.1\| probable transcription regulator protein [Ralstonia solanacearum GMI1000... gi\|17548064 - gi\|17548064\|ref\|NP_521466.1\| transcription regulator protein [Ralstonia solanacearum GMI1000]	147.0	[0..2]	[131..16]
gi\|76882052, gi\|... - gi\|77163738\|ref\|YP_342263.1\| Cu(I)-responsive transcriptional regulator [Nitrosococcus oceani ATCC 1... gi\|207088264 - gi\|207088264\|gb\|EDZ65536.1\| Cu(I)-responsive transcriptional regulator [Nitrosococcus oceani AFC27] gi\|224408610, gi... - gi\|254435153\|ref\|ZP_05048660.1\| Cu(I)-responsive transcriptional regulator [Nitrosococcus oceani AFC...	144.0	[0..1]	[128..2]
HMRR2_RHIME, HMR... - Heavy metal-dependent transcription regulator 2 OS=Rhizobium meliloti GN=hmrR2 PE=3 SV=1, (P58379) H... HMRR2_RHIME - Heavy metal-dependent transcription regulator 2 OS=Rhizobium meliloti (strain 1021) GN=hmrR2 PE=3 SV...	144.0	[0..1]	[132..1]
HMRR_SINMW - HTH-type transcriptional regulator HmrR OS=Sinorhizobium medicae (strain WSM419) GN=hmrR PE=1 SV=1 HMRR_RHIME - HTH-type transcriptional regulator hmrR - Rhizobium meliloti (Sinorhizobium meliloti)	144.0	[0..1]	[130..1]
CUER_ECOL6 - HTH-type transcriptional regulator CueR OS=Escherichia coli O6 GN=cueR PE=3 SV=1 gi\|227838585, gi... - gi\|227884499\|ref\|ZP_04002304.1\| DNA-binding transcriptional regulator CueR [Escherichia coli 83972],... CUER_ECOL6 - HTH-type transcriptional regulator CueR OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPE... gi\|190906025, gi... - gi\|75238241\|ref\|ZP_00722242.1\| COG0789: Predicted transcriptional regulators [Escherichia coli F11],... gi\|110640752, gi... - gi\|110640752\|ref\|YP_668480.1\| DNA-binding transcriptional regulator CueR [Escherichia coli 536], gi\|... gi\|215485567, gi... - gi\|215485567\|ref\|YP_002327998.1\| DNA-binding transcriptional regulator CueR [Escherichia coli O127:H... gi\|218425916, gi... - gi\|218688352\|ref\|YP_002396564.1\| DNA-binding transcriptional regulator CueR [Escherichia coli ED1a],...	143.0	[0..1]	[135..1]
gi\|49076946 - gi\|49076946\|gb\|AAT49618.1\| PA4778 [synthetic construct]	143.0	[0..1]	[133..1]
gi\|15888277, gi\|... - gi\|17934846\|ref\|NP_531636.1\| transcriptional regulator, MerR family [Agrobacterium tumefaciens str. ... gi\|25302889, gi\|... - pir\|\|AB2692 transcription regulator, MerR family cueR [imported] - Agrobacterium tumefaciens (strain...	142.0	[0..1]	[133..1]
gi\|81239916, gi\|... - gi\|82775768\|ref\|YP_402115.1\| DNA-binding transcriptional regulator CueR [Shigella dysenteriae Sd197]...	142.0	[0..1]	[135..1]
gi\|68348510, gi\|... - gi\|70734211\|ref\|YP_257851.1\| Cu(I)-responsive transcriptional regulator [Pseudomonas fluorescens Pf-...	142.0	[0..1]	[130..1]
gi\|218703774, gi... - gi\|218703774\|ref\|YP_002411293.1\| DNA-binding transcriptional regulator CueR [Escherichia coli UMN026... CUER_ECO57 - HTH-type transcriptional regulator CueR OS=Escherichia coli O157:H7 GN=cueR PE=3 SV=1 gi\|218364169, gi... - gi\|218557400\|ref\|YP_002390313.1\| DNA-binding transcriptional regulator CueR [Escherichia coli S88], ... gi\|209778226, gi... - pir\|\|A90697 probable transcription regulator [imported] - Escherichia coli (strain O157:H7, substrai... gi\|208806722, gi... - gi\|208806722\|ref\|ZP_03249059.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7... gi\|195936056 - gi\|195936056\|ref\|ZP_03081438.1\| DNA-binding transcriptional regulator CueR [Escherichia coli O157:H7... gi\|170518676, gi... - gi\|170680958\|ref\|YP_001742631.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli SMS-3-... gi\|91209564, gi\|... - gi\|91209564\|ref\|YP_539550.1\| DNA-binding transcriptional regulator CueR [Escherichia coli UTI89], gi... gi\|168798058, gi... - gi\|189379365\|gb\|EDU97781.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|217321700, gi... - gi\|217325479\|ref\|ZP_03441563.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7... gi\|209160514, gi... - gi\|209399114\|ref\|YP_002269142.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H... gi\|208823109, gi... - gi\|208823109\|ref\|ZP_03263427.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7... gi\|208815585, gi... - gi\|208815585\|ref\|ZP_03256764.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7... gi\|189369139, gi... - gi\|189369139\|gb\|EDU87555.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|168754598, gi... - gi\|189357947\|gb\|EDU76366.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|168747831, gi... - gi\|188017606\|gb\|EDU55728.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|15829799, gi\|... - gi\|15829799\|ref\|NP_308572.1\| DNA-binding transcriptional regulator CueR [Escherichia coli O157:H7 st... gi\|168786345, gi... - gi\|189373706\|gb\|EDU92122.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|168778987, gi... - gi\|189002838\|gb\|EDU71824.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|187769679, gi... - gi\|187769679\|gb\|EDU33523.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|189362424, gi... - gi\|189362424\|gb\|EDU80843.1\| Cu(I)-responsive transcriptional regulator [Escherichia coli O157:H7 str... gi\|226898722, gi... - gi\|237707512\|ref\|ZP_04537993.1\| HTH-type transcriptional regulator cueR [Escherichia sp. 3_2_53FAA],... gi\|117622747, gi... - gi\|117622747\|ref\|YP_851660.1\| DNA-binding transcriptional regulator CueR [Escherichia coli APEC O1],... gi\|254791675, gi... - gi\|254791675\|ref\|YP_003076512.1\| copper responsive transcription regulator [Escherichia coli O157:H7...	142.0	[0..1]	[135..1]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNISDVAKIT GLTSKAIRFY EEKGLVTPPM RSENGYRTYT QQHLNELTLL RQARQVGFNL  60
   61 EESGELVNLF NDPQRHSADV KRRTLEKVAE IERHIEELQS MRDQLLALAN ACPGDDSADC 120
  121 PIIENLSGCC HHRAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.69897
Match:	1q05A
Description:	Crystal structure of the Cu(I) form of E. coli CueR, a copper efflux regulator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.93045200338189	bayes_pls_golite062009
DNA binding	2.76021735963177	bayes_pls_golite062009
nucleic acid binding	2.74030354422037	bayes_pls_golite062009
transcription factor activity	2.40971210693942	bayes_pls_golite062009
binding	2.02368770517087	bayes_pls_golite062009
transcription activator activity	0.653537232350623	bayes_pls_golite062009
protein binding	0.539362924655427	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: