YRC Public Data Repository - Protein Structure Prediction

Protein:	GARL_ECOLI
Organism:	Escherichia coli
Length:	256 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GARL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|52306798, gi\|... - gi\|52424746\|ref\|YP_087883.1\| alpha-dehydro-beta-deoxy-D-glucarate aldolase [Mannheimia succiniciprod...	240.0	[0..1]	[255..1]
gi\|150841239, gi... - gi\|75428542\|ref\|ZP_00731744.1\| 2-dehydro-3-deoxyglucarate aldolase [Actinobacillus succinogenes 130Z...	233.0	[0..1]	[255..1]
gi\|238714323, gi... - gi\|77957772\|ref\|ZP_00821819.1\| COG3836: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Yersinia be...	229.0	[0..1]	[256..1]
gi\|238796073, gi... - gi\|77960684\|ref\|ZP_00824544.1\| COG3836: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Yersinia mo...	229.0	[0..1]	[256..1]
gi\|238787499, gi... - gi\|77973346\|ref\|ZP_00828895.1\| COG3836: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Yersinia fr...	229.0	[0..1]	[256..1]
gi\|50122495, gi\|... - gi\|50122495\|ref\|YP_051662.1\| alpha-dehydro-beta-deoxy-D-glucarate aldolase [Pectobacterium atrosepti...	227.0	[0..1]	[256..1]
gi\|77977135, gi\|... - gi\|77977135\|ref\|ZP_00832592.1\| COG3836: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Yersinia in...	227.0	[0..1]	[256..1]
GARL_ECOL6 - 5-keto-4-deoxy-D-glucarate aldolase OS=Escherichia coli O6 GN=garL PE=3 SV=1 gi\|227887848, gi... - gi\|227887848\|ref\|ZP_04005653.1\| alpha-dehydro-beta-deoxy-D-glucarate aldolase [Escherichia coli 8397... GARL_ECOL6 - 5-keto-4-deoxy-D-glucarate aldolase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) G...	226.0	[0..1]	[256..1]
gi\|27479658 - gi\|27479658\|gb\|AAO17185.1\| HpaI [Photorhabdus luminescens]	226.0	[0..3]	[254..1]
GARL_SHISS - 5-keto-4-deoxy-D-glucarate aldolase OS=Shigella sonnei (strain Ss046) GN=garL PE=3 SV=1	226.0	[0..1]	[256..1]

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Predicted Domain #1

Region A:
Residues: [1-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNDVFPNKF KAALAAKQVQ IGCWSALSNP ISTEVLGLAG FDWLVLDGEH APNDISTFIP  60
   61 QLMALKGSAS APVVRVPTNE PVIIKRLLDI GFYNFLIPFV ETKEEAELAV ASTRYPPEGI 120
  121 RGVSVSHRAN MFGTVADYFA QSNKNITILV QIESQQGVDN VDAIAATEGV DGIFVGPSDL 180
  181 AAALGHLGNA SHPDVQKAIQ HIFNRASAHG KPSGILAPVE ADARRYLEWG ATFVAVGSDL 240
  241 GVFRSATQKL ADTFKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.69897
Match:	1dxeA
Description:	2-dehydro-3-deoxy-galactarate aldolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.59838799615646	bayes_pls_golite062009
oxo-acid-lyase activity	0.920775369999745	bayes_pls_golite062009
carbon-carbon lyase activity	0.5165407619773	bayes_pls_golite062009
2-dehydro-3-deoxyglucarate aldolase activity	0.476503494662165	bayes_pls_golite062009
binding	0.415920162243587	bayes_pls_golite062009
transferase activity	0.368032846714701	bayes_pls_golite062009
lyase activity	0.0456521871650777	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: