YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|149365066, gi...
Organism:	Yersinia pestis CA88-4125
Length:	461 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|149365066, gi....

Description	E-value	Query Range	Subject Range
gi\|68547081, gi\|... - gi\|68547081\|ref\|ZP_00586622.1\| Cysteinyl-tRNA synthetase, class Ia [Shewanella amazonensis SB2B], gi...	1.0E-99	[1..461]	[195..653]
SYC_YERPS - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis GN=cysS PE=3 SV=1 SYC_YERPB - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=cysS PE=3 SV=1 SYC_YERPS - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysS PE=3 SV=1	3.0E-99	[1..461]	[1..461]
gi\|22125011, gi\|... - gi\|22125011\|ref\|NP_668434.1\| cysteinyl-tRNA synthetase [Yersinia pestis KIM], gi\|21957858\|gb\|AAM8468... gi\|45440695, gi\|... - gi\|45440695\|ref\|NP_992234.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Microtus str. 91001],...	7.0E-99	[1..461]	[16..476]
SYC_HAEI8 - Cysteine--tRNA ligase OS=Haemophilus influenzae (strain 86-028NP) GN=cysS PE=3 SV=1	2.0E-98	[1..461]	[1..459]
gi\|77958384 - gi\|77958384\|ref\|ZP_00822418.1\| COG0215: Cysteinyl-tRNA synthetase [Yersinia bercovieri ATCC 43970]	2.0E-98	[1..461]	[20..480]
gi\|37198290, gi\|... - gi\|37679546\|ref\|NP_934155.1\| cysteinyl-tRNA synthetase [Vibrio vulnificus YJ016], gi\|37198290\|dbj\|BA...	6.0E-98	[1..461]	[50..509]
gi\|238790851, gi... - gi\|77974235\|ref\|ZP_00829776.1\| COG0215: Cysteinyl-tRNA synthetase [Yersinia frederiksenii ATCC 33641...	1.0E-97	[1..461]	[13..473]
SYC_SODGM - Cysteine--tRNA ligase OS=Sodalis glossinidius (strain morsitans) GN=cysS PE=3 SV=1	2.0E-97	[1..460]	[1..456]
gi\|77962150, gi\|... - gi\|77962150\|ref\|ZP_00825974.1\| COG0215: Cysteinyl-tRNA synthetase [Yersinia mollaretii ATCC 43969], ...	3.0E-97	[1..461]	[1..461]
gi\|84391753, gi\|... - gi\|84391753\|ref\|ZP_00991655.1\| cysteinyl-tRNA synthetase [Vibrio splendidus 12B01], gi\|84376466\|gb\|E...	5.0E-97	[1..461]	[1..461]

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Predicted Domain #1

Region A:
Residues: [1-461]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKIFNTLSR QKEEFKPIHA GKVGMYVCGI TIYDLCHIGH GRTFVAFDVV ARYLRYLGYS  60
   61 LTYVRNVTDV DDKIIKRAIE NNETCEQLTT RMLAEMHKDF DALNLERPDL EPRATHHIAE 120
  121 IIEMTERLIA RGHAYVASNG DVMFAVDSDP DYGVLSRQDL DQLQAGARVE VADVKRNPMD 180
  181 FVLWKMSKPG EPRWESPWGP GRPGWHIECS AMNGKQLGAH FDIHGGGSDL MFPHHENEIA 240
  241 QSTCAHDGPY VNYWMHSGMV MIDKEKMSKS LNNFFTIRDV LAYYDAETVR YFLMSGHYRS 300
  301 QLNYSEENLK QARASLERLY TALRGTDANA TPAGGAEFEA RFRTAMDDDF NTPEAYSVLF 360
  361 DIAREVNRLK NEDMAAANGL AAELRKLAQV LGLLEQDPEL FLQGGAQADD DEVAKIEALI 420
  421 KQRNDARSSK NWALADAARD QLNELGIVLE DGPQGTTWRR K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.154902
Match:	1li5A
Description:	Cysteinyl-tRNA synthetase (CysRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
cysteine-tRNA ligase activity	5.23703961447809	bayes_pls_golite062009
isoleucine-tRNA ligase activity	3.76808520367507	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
methionine-tRNA ligase activity	2.01261843164558	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
arginine-tRNA ligase activity	1.13743634264647	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
nucleic acid binding	0.161799496958314	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.126511747475258	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: