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View Structure Prediction Details

Protein: GCH1_SYNY3
Organism: Synechocystis sp. PCC 6803
Length: 234 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_SYNY3.

Description E-value Query
Range		 Subject
Range
gi|75702476, gi|... - gi|75908751|ref|YP_323047.1| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi|75702476|gb|A...
 360.0 [0..1] [234..1]
gi|25290301 - pir||AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120)
GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1
 358.0 [0..1] [234..1]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1
 352.0 [0..1] [234..1]
GCH1_SYNEL - GTP cyclohydrolase 1 OS=Synechococcus elongatus GN=folE PE=3 SV=1
GCH1_THEEB - GTP cyclohydrolase 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=folE PE=3 SV=1
 347.0 [0..2] [233..3]
gi|46118361, gi|... - gi|67925134|ref|ZP_00518508.1| GTP cyclohydrolase I [Crocosphaera watsonii WH 8501], gi|67853028|gb|...
 342.0 [0..1] [234..1]
GCH1_SYNE7 - GTP cyclohydrolase 1 OS=Synechococcus elongatus (strain PCC 7942) GN=folE PE=3 SV=2
GCH1_SYNP6 - GTP cyclohydrolase 1 OS=Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) GN=folE PE=3 ...
 331.0 [0..24] [234..2]
gi|22002492 - gi|22002492|gb|AAM82644.1| Gch1 [Synechococcus sp. PCC 7942]
 330.0 [0..24] [234..8]
gi|71676843, gi|... - gi|71676843|ref|ZP_00674583.1| GTP cyclohydrolase I [Trichodesmium erythraeum IMS101], gi|71670020|g...
 328.0 [0..7] [234..16]
gi|157016227, gi... - gi|58388701|ref|XP_316477.2| ENSANGP00000013527 [Anopheles gambiae str. PEST], gi|55239212|gb|EAA118...
AGAP006441-PA - GTP cyclohydrolase I|protein_coding|2L:32022399:32030633:-1|gene:AGAP006441
 327.0 [0..8] [230..118]

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Predicted Domain #1
Region A:
Residues: [1-234] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIASSHSIN NGMNTGKLVN QLSSLPDRNT HNGQEVKYHP ENVELNKEKM MDAVRVMLES  60
   61 VGEDPEREGL LKTPKRVAEA MQFLTQGYDQ SLEKLVNGAI FDEGHNEMVL VRDIDFFSLC 120
  121 EHHMLPFMGK AHLAYIPNQK VVGLSKLARI VEMFSRRLQV QERLTRQIAE AVQEILDPQG 180
  181 VAVVMEATHM CMVMRGVQKP GSWTVTSAMI GSFQNEQKTR EEFLNLIRHQ PNFY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.045757
Match: 1is7A
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 5.27071565931386 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.94513271787536 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
binding 1.62520629128577 bayes_pls_golite062009
protein binding 1.34873192832825 bayes_pls_golite062009
hydrolase activity 1.10190985324326 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
carbon-carbon lyase activity 0.25616855487144 bayes_pls_golite062009
urate oxidase activity 0.0294957696532921 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle