YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|151941602
Organism:	Saccharomyces cerevisiae YJM789
Length:	328 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|151941602.

Description	E-value	Query Range	Subject Range
gi\|1174562, gi\|6... - gi\|607956\|gb\|AAA62664.1\| transcription factor TFIIE, small subunit, gi\|1174562\|sp\|P36145.2\|T2EB_YEAS...	0.0	[1..328]	[1..328]
T2EB_SCHPO - Transcription initiation factor IIE subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 248... tfa2 - transcription factor TFIIE beta subunit Tfa2	9.0E-92	[62..325]	[15..281]
gi\|1834288 - gi\|1834288\|dbj\|BAA19123.1\| S.pombe TFA2 homolog [Schizosaccharomyces pombe]	5.0E-78	[109..325]	[1..220]
CE26813 - transcription intiation factor TFIIE-BETA status:Confirmed UniProt:Q20776 protein_id:CAA91336.2	1.0E-76	[47..324]	[7..288]
gi\|157071405, gi... - gi\|164426610\|ref\|XP_957548.2\| hypothetical protein NCU03909 [Neurospora crassa OR74A], gi\|157071405\|... gi\|16945428 - gi\|16945428\|emb\|CAB91686.2\| related to transcription initiation factor IIE, beta subunit [Neurospora...	2.0E-74	[50..326]	[3..299]
GTF2E2 - general transcription factor IIE, polypeptide 2, beta 34kDa gi\|55630478, gi\|... - gi\|55630478\|ref\|XP_519695.1\| PREDICTED: general transcription factor IIE, polypeptide 2, beta 34kDa ... gi\|208966362 - gi\|208966362\|dbj\|BAG73195.1\| general transcription factor IIE, polypeptide 2, beta 34kDa [synthetic ...	8.0E-66	[47..325]	[7..285]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	2.0E-65	[47..325]	[7..285]

Back

Predicted Domain #1

Region A:
Residues: [1-96]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNRDPLLA NLNAFKSKVK SAPVIAPAKV GQKKTNDTVI TIDGNTRKRT ASERAQENTL  60
   61 NSAKNPVLVD IKKEAGSNSS NAISLDDDDD DEDFGS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.205	d.95.2	Homing endonucleases
View	Download	0.205	d.95.2	Homing endonucleases
View	Download	0.220	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.220	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain

Predicted Domain #2

Region A:
Residues: [97-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSKKVRPGS IAAAALQANQ TDISKSHDSS KLLWATEYIQ KKGKPVLVNE LLDYLSMKKD  60
   61 DKVIELLKKL DRIEFDPKKG TFKYLSTYDV H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1d8jA_
Description:	The central core domain of TFIIE beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.67074370996647	bayes_pls_golite062009
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	4.84466441605416	bayes_pls_golite062009
nucleic acid binding	4.57954522145536	bayes_pls_golite062009
transcription factor activity	4.12685284895733	bayes_pls_golite062009
binding	4.05190810999633	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
sequence-specific DNA binding	2.3918869755162	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
transcription repressor activity	2.22485867684613	bayes_pls_golite062009
DNA-directed RNA polymerase activity	1.82365519759474	bayes_pls_golite062009
RNA polymerase activity	1.82365519759474	bayes_pls_golite062009
protein binding	0.961087148890615	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
nucleotidyltransferase activity	0.237727660028553	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.157471576785569	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.0360186926687502	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [188-328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSELLKLLR SQVTFKGISC KDLKDGWPQC DETINQLEED SKILVLRTKK DKTPRYVWYN  60
   61 SGGNLKCIDE EFVKMWENVQ LPQFAELPRK LQDLGLKPAS VDPATIKRQT KRVEVKKKRQ 120
  121 RKGKITNTHM TGILKDYSHR V

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.301	d.93.1	SH2 domain
View	Download	0.301	d.93.1	SH2 domain
View	Download	0.265	b.33.1	ISP domain
View	Download	0.265	b.33.1	ISP domain
View	Download	0.278	d.93.1	SH2 domain
View	Download	0.214	b.33.1	ISP domain
View	Download	0.214	b.33.1	ISP domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: