YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|151945987
Organism:	Saccharomyces cerevisiae YJM789
Length:	540 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|151945987.

Description	E-value	Query Range	Subject Range
YMR279C - Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen;... YM8M_YEAST - Uncharacterized transporter YMR279C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMR2... gi\|151945987 - gi\|151945987\|gb\|EDN64219.1\| conserved protein [Saccharomyces cerevisiae YJM789]	4.0E-79	[1..540]	[1..540]
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	6.0E-79	[64..493]	[1..419]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	2.0E-76	[63..504]	[6..439]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	3.0E-76	[63..504]	[6..439]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	1.0E-75	[36..492]	[5..444]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	3.0E-75	[71..504]	[13..438]
gi\|124528057, gi... - gi\|124528057\|ref\|ZP_01699410.1\| drug resistance transporter, EmrB/QacA subfamily [Escherichia coli B... EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|189362003, gi... - gi\|189362003\|gb\|EDU80422.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4486], g... gi\|189367267, gi... - gi\|189367267\|gb\|EDU85683.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4501], g... gi\|168778668, gi... - gi\|189003608\|gb\|EDU72594.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4076], g... gi\|187769639, gi... - gi\|187769639\|gb\|EDU33483.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4196], g... gi\|189377146, gi... - gi\|189377146\|gb\|EDU95562.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC508], gi... gi\|189372123, gi... - gi\|189372123\|gb\|EDU90539.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC869], gi... gi\|169890103, gi... - gi\|170082268\|ref\|YP_001731588.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr.... gi\|170019063, gi... - gi\|170019063\|ref\|YP_001724017.1\| EmrB/QacA family drug resistance transporter [Escherichia coli ATCC... gi\|1800071, gi\|8... - gi\|89109478\|ref\|AP_003258.1\| multidrug efflux system protein [Escherichia coli str. K-12 substr. W31... gi\|15832802, gi\|... - gi\|15832802\|ref\|NP_311575.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. Sakai], g... gi\|189357296, gi... - gi\|189357296\|gb\|EDU75715.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4401], g... gi\|188014965, gi... - gi\|188014965\|gb\|EDU53087.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4113], g... gi\|218706185, gi... - gi\|218706185\|ref\|YP_002413704.1\| multidrug efflux system protein [Escherichia coli UMN026], gi\|21843... gi\|218353014, gi... - gi\|218696282\|ref\|YP_002403949.1\| multidrug efflux system protein [Escherichia coli 55989], gi\|218353... gi\|238861814, gi... - gi\|238901828\|ref\|YP_002927624.1\| multidrug efflux system protein [Escherichia coli BW2952], gi\|23886... gi\|251785975, gi... - gi\|251785975\|ref\|YP_003000279.1\| hypothetical protein B21_02506 [Escherichia coli BL21], gi\|24237824... gi\|253978690, gi... - gi\|254289383\|ref\|YP_003055131.1\| multidrug efflux system protein [Escherichia coli BL21(DE3)], gi\|25... gi\|253974523, gi... - gi\|254162622\|ref\|YP_003045730.1\| multidrug efflux system protein [Escherichia coli B str. REL606], g... gi\|254594032, gi... - gi\|254794632\|ref\|YP_003079469.1\| multidrug efflux system protein [Escherichia coli O157:H7 str. TW14... EMRB_ECO57 - Multidrug export protein EmrB OS=Escherichia coli O157:H7 GN=emrB PE=3 SV=1 gi\|195938439 - gi\|195938439\|ref\|ZP_03083821.1\| membrane translocase [Escherichia coli O157:H7 str. EC4024] EG11439 - multidrug efflux system protein / EmrAB-TolC multidrug resistance pump; energy-dependent efflux of o... gi\|194427903, gi... - gi\|194427903\|ref\|ZP_03060449.1\| multidrug resistance protein B [Escherichia coli B171], gi\|194414136... gi\|208811845, gi... - gi\|208811845\|ref\|ZP_03253174.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4045... gi\|208726552, gi... - gi\|208806751\|ref\|ZP_03249088.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4206... gi\|209396264, gi... - gi\|209396264\|ref\|YP_002272153.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC411... gi\|208741288, gi... - gi\|208821165\|ref\|ZP_03261485.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. EC4042... gi\|217319664, gi... - gi\|217327297\|ref\|ZP_03443380.1\| multidrug resistance protein B [Escherichia coli O157:H7 str. TW1458... gi\|209920130, gi... - gi\|209920130\|ref\|YP_002294214.1\| multidrug resistance protein [Escherichia coli SE11], gi\|209913389\|... gi\|194439446, gi... - gi\|83585148\|ref\|ZP_00923799.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157077975, gi... - gi\|75187410\|ref\|ZP_00700677.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157162137, gi... - gi\|75196666\|ref\|ZP_00706736.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|75229766, gi\|... - gi\|75229766\|ref\|ZP_00716296.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|193071001, gi... - gi\|75234098\|ref\|ZP_00718509.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|188486943, gi... - gi\|75513256\|ref\|ZP_00735698.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... EMRB_ECOLI - Multidrug resistance protein B - Escherichia coli	2.0E-72	[63..504]	[6..439]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-72	[33..496]	[13..464]
gi\|25306170 - gi\|25306170\|pir\|\|G85916 hypothetical protein emrB [imported] - Escherichia coli (strain O157:H7, su... gi\|12517127, gi\|... - gi\|15803205\|ref\|NP_289237.1\| multidrug resistance protein B [Escherichia coli O157:H7 EDL933], gi\|12...	6.0E-72	[63..504]	[6..439]
EMRB_HAEIN - Multidrug export protein EmrB OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) ... EMRB_HAEIN - Multidrug resistance protein B homolog OS=Haemophilus influenzae GN=emrB PE=3 SV=1	6.0E-72	[66..500]	[13..439]

Back

Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSIFKKKTS VQGTDSEIDE KITVKAKDKV VVSTEDEEVT TIVSSTKSTQ VTNDSPWQDP  60
   61 TYFSSFGKEL MFIATCMLAQ LLNQAGQTHA LCIMNVLSKS FNSEANNQAW LMASFPLAAG 120
  121 SFILISGRLG DIYGLKKMLI VGYVIVIVWS IISGLSKYSN SDAFFITSRA FQGVGIAFIL 180
  181 PNIMGLVGHV YKVGSFRKNI VISFIGACAP TGGMFGGLFG GLIVTEDPNQ WPWVFYAFGI 240
  241 ATFLSLLMAW YSI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [321-540]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVPLLPRAMT KNRHMIMILL AVFLGWGSFG IWTFYYVSFQ LNLRHYSPVW TGGTYFVFVI  60
   61 FGSMAAFFVA FSIKRLGPAL LLCFSLMAFD AGSIMFSVLP VEQSYWKLNF AMQAILCFGM 120
  121 DLSFPASSII LSDGLPMQYQ GMAGSLVNTV INYSASLCLG MGGTVEHQIN KSGNDLLKGY 180
  181 RAAVYLGVGL ASLGVVISVT YMLENLWNRH RKSEDRSLEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.09691
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transporter activity	3.3426261924492	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29689809004391	bayes_pls_golite062009
ion transmembrane transporter activity	1.94035843948137	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
cation transmembrane transporter activity	1.5181741634556	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [254-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNNVPTNIHG LSMDWTGSAL AIIGLILFNF VWNQAPIVGW DKPYIIVLLI ISVIFLVAFF  60
   61 VYESKYA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.09691
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: