YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|70780284
Organism:	Plasmodium falciparum
Length:	435 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|70780284.

Description	E-value	Query Range	Subject Range
gi\|90324688, gi\|... - gi\|90414241\|ref\|ZP_01222221.1\| porphobilinogen deaminase [Photobacterium profundum 3TCK], gi\|9032468...	450.0	[0..48]	[427..22]
HEM3_VIBVY - Porphobilinogen deaminase OS=Vibrio vulnificus (strain YJ016) GN=hemC PE=3 SV=1 HEM3_VIBVU - Porphobilinogen deaminase OS=Vibrio vulnificus GN=hemC PE=3 SV=1 HEM3_VIBVU - Porphobilinogen deaminase OS=Vibrio vulnificus (strain CMCP6) GN=hemC PE=3 SV=1	447.0	[0..56]	[428..1]
gi\|149747840, gi... - gi\|153838754\|ref\|ZP_01991421.1\| porphobilinogen deaminase [Vibrio parahaemolyticus AQ3810], gi\|14974... HEM3_VIBPA - Porphobilinogen deaminase OS=Vibrio parahaemolyticus GN=hemC PE=3 SV=1 HEM3_VIBPA - Porphobilinogen deaminase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=hemC PE...	446.0	[0..56]	[428..1]
gi\|81247567, gi\|... - gi\|82546156\|ref\|YP_410103.1\| porphobilinogen deaminase [Shigella boydii Sb227], gi\|81247567\|gb\|ABB68...	445.0	[0..52]	[425..2]
gi\|15833989, gi\|... - gi\|15833989\|ref\|NP_312762.1\| porphobilinogen deaminase [Escherichia coli O157:H7], gi\|13364211\|dbj\|B... gi\|209753312, gi... - gi\|25292187\|pir\|\|A86067 porphobilinogen deaminase [imported] - Escherichia coli (strain O157:H7, su... gi\|15804393, gi\|... - gi\|15804393\|ref\|NP_290433.1\| porphobilinogen deaminase [Escherichia coli O157:H7 EDL933], gi\|1251866... gi\|15833989, gi\|... - gi\|15833989\|ref\|NP_312762.1\| porphobilinogen deaminase [Escherichia coli O157:H7 str. Sakai], gi\|133...	445.0	[0..52]	[425..2]
gi\|32033974 - gi\|32033974\|ref\|ZP_00134230.1\| COG0181: Porphobilinogen deaminase [Actinobacillus pleuropneumoniae s...	445.0	[0..53]	[426..1]
gi\|75512636 - gi\|75512636\|ref\|ZP_00735148.1\| COG0181: Porphobilinogen deaminase [Escherichia coli 53638]	445.0	[0..53]	[425..1]
gi\|194434066, gi... - gi\|83569364\|ref\|ZP_00920819.1\| COG0181: Porphobilinogen deaminase [Shigella dysenteriae 1012], gi\|19...	445.0	[0..53]	[425..1]
gi\|226902983, gi... - gi\|237702812\|ref\|ZP_04533293.1\| porphobilinogen deaminase [Escherichia sp. 3_2_53FAA], gi\|226902983\|... gi\|115515186, gi... - gi\|117626062\|ref\|YP_859385.1\| porphobilinogen deaminase [Escherichia coli APEC O1], gi\|115515186\|gb\|... gi\|91074900, gi\|... - gi\|91213326\|ref\|YP_543312.1\| porphobilinogen deaminase [Escherichia coli UTI89], gi\|91074900\|gb\|ABE0...	444.0	[0..52]	[425..2]
gi\|26110973, gi\|... - gi\|26250543\|ref\|NP_756583.1\| porphobilinogen deaminase [Escherichia coli CFT073], gi\|26110973\|gb\|AAN... gi\|110345720, gi... - gi\|110644128\|ref\|YP_671858.1\| porphobilinogen deaminase [Escherichia coli 536], gi\|110345720\|gb\|ABG7... gi\|227888613, gi... - gi\|227888613\|ref\|ZP_04006418.1\| hydroxymethylbilane synthase [Escherichia coli 83972], gi\|227834452\|...	444.0	[0..52]	[425..2]

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Predicted Domain #1

Region A:
Residues: [1-435]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLLSFLSFI IWFIHCTAKR HEYSIKKYFL NSHNFCKIKP DPFRKDTLKK RLYSSDGIKD  60
   61 EIIIGTRDSP LALKQSEKVR KKIMSYFKKM NKNINVTFKY IKTTGDNILD SKSVGLYGGK 120
  121 GIFTKELDEQ LINGNVDLCV HSLKDVPILL PNNIELSCFL KRDTINDAFL SIKYKSINDM 180
  181 NTVKSVSKTE DIHHINKKDS DHNNDTLCTI GTSSLRRRSQ IKNRYKNIYV NNIRGNINTR 240
  241 IEKLYNGEVD ALIIAMCGIE RLIKKANLKH LLKNKEQKNI CQPFLLKCNN KKCIDLCHVN 300
  301 IQKLNKNLIY PALGQGIIAV TSHKKNYFIS SLLKNINNKK SEMMAQIERS FLYHIDGNCM 360
  361 MPIGGYTNMR NEDIYLHVII NDIHGYNKYQ VTQKDTLYNY KEIGPNAAIK MKEIIGTEQF 420
  421 NKIKAEAELH LLNNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	124.0
Match:	1ah5A
Description:	REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.22743737647397	bayes_pls_golite062009
DNA binding	2.86883926687971	bayes_pls_golite062009
transcription factor activity	2.7948293378347	bayes_pls_golite062009
nucleic acid binding	2.66637887681284	bayes_pls_golite062009
binding	2.63182502368928	bayes_pls_golite062009
hydroxymethylbilane synthase activity	2.03196514141563	bayes_pls_golite062009
catalytic activity	0.674312982669564	bayes_pls_golite062009
transcription activator activity	0.050905489018976	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: