YRC Public Data Repository - Protein Structure Prediction

Protein:	HTPX_ECO57
Organism:	Escherichia coli O157:H7
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HTPX_ECO57.

Description	E-value	Query Range	Subject Range
gi\|16760732 - gi\|16760732\|ref\|NP_456349.1\| heat shock protein HtpX [Salmonella enterica subsp. enterica serovar Ty... HTPX_SALDC - Protease HtpX OS=Salmonella dublin (strain CT_02021853) GN=htpX PE=3 SV=1 HTPX_SALPK - Protease HtpX OS=Salmonella paratyphi A (strain AKU_12601) GN=htpX PE=3 SV=1 HTPX_SALTY - Protease HtpX OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=htpX PE=3 SV=1 gi\|197241190, gi... - gi\|197262935\|ref\|ZP_03163009.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar S... gi\|29137137, gi\|... - gi\|29141510\|ref\|NP_804852.1\| heat shock protein HtpX [Salmonella enterica subsp. enterica serovar Ty... HTPX_SALA4 - Protease HtpX OS=Salmonella agona (strain SL483) GN=htpX PE=3 SV=1 HTPX_SALEP - Protease HtpX OS=Salmonella enteritidis PT4 (strain P125109) GN=htpX PE=3 SV=1 HTPX_SALG2 - Protease HtpX OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=htpX PE=3 SV=1 gi\|204931090, gi... - gi\|204931090\|ref\|ZP_03221916.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar J... gi\|199603491, gi... - gi\|200391046\|ref\|ZP_03217657.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar V... gi\|205342580, gi... - gi\|205342580\|gb\|EDZ29344.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Welte... gi\|195634383, gi... - gi\|195634383\|gb\|EDX52735.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Newpo... gi\|205350590, gi... - gi\|205350590\|gb\|EDZ37221.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Hadar... gi\|168241443, gi... - gi\|205339124\|gb\|EDZ25888.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Heide... HTPX_SALSV - Protease HtpX OS=Salmonella schwarzengrund (strain CVM19633) GN=htpX PE=3 SV=1 gi\|194470673, gi... - gi\|194470673\|ref\|ZP_03076657.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar K... HTPX_SALHS - Protease HtpX OS=Salmonella heidelberg (strain SL476) GN=htpX PE=3 SV=1 HTPX_SALNS - Protease HtpX OS=Salmonella newport (strain SL254) GN=htpX PE=3 SV=1 HTPX_SALCH - Protease HtpX OS=Salmonella choleraesuis GN=htpX PE=3 SV=1 HTPX_SALPC - Protease HtpX OS=Salmonella paratyphi C (strain RKS4594) GN=htpX PE=3 SV=1 HTPX_SALPA - Protease HtpX OS=Salmonella paratyphi A GN=htpX PE=3 SV=1 HTPX_SALTI - Protease HtpX OS=Salmonella typhi GN=htpX PE=3 SV=1 HTPX_SALCH - Probable protease htpX OS=Salmonella choleraesuis GN=htpX PE=3 SV=1 HTPX_SALTY - Protease HtpX OS=Salmonella typhimurium GN=htpX PE=3 SV=1 HTPX_SALAR - Protease HtpX OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) GN=htpX PE=3 SV=1 HTPX_SALTY - Probable protease htpX OS=Salmonella typhimurium GN=htpX PE=3 SV=1 lcl\|NC_016856.1_... - [gene=htpX] [protein=heat shock protein HtpX] [protein_id=YP_005237790.1] [location=complement(19514... gi\|197288677, gi... - gi\|197288677\|gb\|EDY28052.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Schwa... HTPX_SALCH - Protease HtpX OS=Salmonella choleraesuis (strain SC-B67) GN=htpX PE=3 SV=1 gi\|168234256, gi... - gi\|205331764\|gb\|EDZ18528.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Kentu... HTPX_SALPA - Protease HtpX OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=htpX PE=3 SV=1 gi\|167993796, gi... - gi\|205328234\|gb\|EDZ14998.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar 4,[5]... HTPX_SALTI - Probable protease htpX OS=Salmonella typhi GN=htpX PE=3 SV=1 gi\|167553469, gi... - gi\|205322082\|gb\|EDZ09921.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Saint...	259.0	[0..1]	[293..1]
HTPX_ERWCT - Protease HtpX OS=Erwinia carotovora subsp. atroseptica GN=htpX PE=3 SV=1 HTPX_PECAS - Protease HtpX OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=htpX PE=3 SV=1	258.0	[0..1]	[293..1]
gi\|194417239, gi... - gi\|83569085\|ref\|ZP_00920546.1\| COG0501: Zn-dependent protease with chaperone function [Shigella dyse...	258.0	[0..1]	[293..1]
gi\|25296090 - gi\|25296090\|pir\|\|G85794 heat shock protein, integral membrane protein [imported] - Escherichia coli ... gi\|15802243, gi\|... - gi\|15802243\|ref\|NP_288266.1\| heat shock protein HtpX [Escherichia coli O157:H7 EDL933], gi\|12515876\|...	258.0	[0..1]	[293..1]
gi\|89108669, gi\|... - gi\|89108669\|ref\|AP_002449.1\| predicted endopeptidase [Escherichia coli str. K-12 substr. W3110], gi\|... HTPX_ECOLI - Probable protease htpX (EC 3.4.24.-) (Heat shock protein htpX) - Escherichia coli EG10462 - putative endopeptidase / Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitr... HTPX_ECOBW - Protease HtpX OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=htpX PE=3 SV=1 HTPX_ECODH - Protease HtpX OS=Escherichia coli (strain K12 / DH10B) GN=htpX PE=3 SV=1 EG10462 - putative endopeptidase / Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitr...	258.0	[0..1]	[293..1]
gi\|254288677, gi... - gi\|254288677\|ref\|YP_003054425.1\| heat shock protein HtpX [Escherichia coli BL21(DE3)], gi\|253977984\|... gi\|83584508, gi\|... - gi\|83584508\|ref\|ZP_00923186.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... gi\|242377550, gi... - gi\|251785277\|ref\|YP_002999581.1\| hypothetical protein B21_01788 [Escherichia coli BL21], gi\|24237755... gi\|254161889, gi... - gi\|254161889\|ref\|YP_003044997.1\| heat shock protein HtpX [Escherichia coli B str. REL606], gi\|253973...	257.0	[0..1]	[293..1]
gi\|238724840, gi... - gi\|77975215\|ref\|ZP_00830751.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia fred...	256.0	[0..1]	[293..1]
gi\|56479890, gi\|... - gi\|56479890\|ref\|NP_707290.2\| heat shock protein HtpX [Shigella flexneri 2a str. 301], gi\|56383441\|gb... gi\|30062915, gi\|... - gi\|30062915\|ref\|NP_837086.1\| heat shock protein HtpX [Shigella flexneri 2a str. 2457T], gi\|30041164\|... gi\|195939730 - gi\|195939730\|ref\|ZP_03085112.1\| heat shock protein HtpX [Escherichia coli O157:H7 str. EC4024]	256.0	[0..2]	[293..1]
gi\|238728851, gi... - gi\|77980102\|ref\|ZP_00835517.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia inte...	254.0	[0..1]	[293..1]
HTPX_YERPG - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Angola) GN=htpX PE=3 SV=1 HTPX_YERP3 - Protease HtpX OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=htpX PE=3 SV=1 HTPX_YERPS - Protease HtpX OS=Yersinia pseudotuberculosis GN=htpX PE=3 SV=1 HTPX_YERPE - Protease HtpX OS=Yersinia pestis GN=htpX PE=3 SV=1 gi\|165992656, gi... - gi\|166008274\|ref\|ZP_02229172.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. E1979001]... gi\|165925521, gi... - gi\|165925521\|ref\|ZP_02221353.1\| peptidase, M48 family [Yersinia pestis biovar Orientalis str. F19910... gi\|167048896, gi... - gi\|167401791\|ref\|ZP_02307282.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. UG05-0454... gi\|166210679, gi... - gi\|166210679\|ref\|ZP_02236714.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. B42003004... gi\|167426790, gi... - gi\|167426790\|ref\|ZP_02318543.1\| peptidase, M48 family [Yersinia pestis biovar Mediaevalis str. K1973... gi\|167422601, gi... - gi\|167422601\|ref\|ZP_02314354.1\| peptidase, M48 family [Yersinia pestis biovar Orientalis str. MG05-1... HTPX_YERPY - Protease HtpX OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=htpX PE=3 SV=1 gi\|167467650 - gi\|167467650\|ref\|ZP_02332354.1\| peptidase, M48 family protein [Yersinia pestis FV-1] HTPX_YERPA - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=htpX PE=3 SV=1 HTPX_YERPN - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=htpX PE=3 SV=1 gi\|45436404, gi\|... - gi\|45441543\|ref\|NP_993082.1\| heat shock protein HtpX [Yersinia pestis biovar Microtus str. 91001], g... gi\|21958684, gi\|... - gi\|22125761\|ref\|NP_669184.1\| heat shock protein HtpX [Yersinia pestis KIM], gi\|21958684\|gb\|AAM85435.... gi\|16121966, gi\|... - gi\|218928834\|ref\|YP_002346709.1\| heat shock protein HtpX [Yersinia pestis CO92], gi\|16121966\|ref\|NP_... HTPX_YERPS - Protease HtpX OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=htpX PE=3 SV=1 gi\|89103074, gi\|... - gi\|89103074\|ref\|ZP_01175669.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia pest... gi\|149290713, gi... - gi\|149366339\|ref\|ZP_01888373.1\| putative heat shock protein [Yersinia pestis CA88-4125], gi\|14929071... HTPX_YERPB - Protease HtpX OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=htpX PE=3 SV=1 gi\|229843820, gi... - gi\|229843820\|ref\|ZP_04463963.1\| predicted endopeptidase [Yersinia pestis biovar Orientalis str. Indi... HTPX_YERPP - Protease HtpX OS=Yersinia pestis (strain Pestoides F) GN=htpX PE=3 SV=1 gi\|229702425, gi... - gi\|229894670\|ref\|ZP_04509851.1\| predicted endopeptidase [Yersinia pestis Pestoides A], gi\|229702425\|... gi\|229897080, gi... - gi\|229897080\|ref\|ZP_04512236.1\| predicted endopeptidase [Yersinia pestis biovar Orientalis str. PEXU...	254.0	[0..1]	[293..1]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR  60
   61 SVGGEVIEQP

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	19.744727
Match:	PF06509.2
Description:	No description for PF06509.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [71-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNERERWLVN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV STGLLQNMSP  60
   61 DEAEAVIAHE ISHI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.05
Match:	1c7kA
Description:	Zinc protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.52170890235712	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.20265930105587	bayes_pls_golite062009
metallopeptidase activity	2.46762211541241	bayes_pls_golite062009
hydrolase activity	2.3590043825345	bayes_pls_golite062009
endopeptidase activity	2.3107572739426	bayes_pls_golite062009
metalloendopeptidase activity	1.69802747425985	bayes_pls_golite062009
catalytic activity	0.843772148375291	bayes_pls_golite062009
binding	0.655247478888488	bayes_pls_golite062009
protein binding	0.273409914175328	bayes_pls_golite062009
exopeptidase activity	0.160545038651425	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [145-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANGDMVTMTL IQGVVNTFVI FISRILAQLA AGFMGGNRDE GEESNGNPLI YFAVATVLEL  60
   61 VFGILASIIT MWFSRHREFH ADAGSAKLVG REKMIAALQR LKTSYEPQEA TSMMAFCING 120
  121 KSKSLSELFM THPPLDKRIE ALRTGEYLK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	3.60206
Match:	PF01435.9
Description:	No description for PF01435.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: