YRC Public Data Repository - Protein Structure Prediction

Protein:	IPYR_ECOLI
Organism:	Escherichia coli
Length:	175 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IPYR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67157940, gi\|... - gi\|67157940\|ref\|ZP_00419085.1\| Inorganic diphosphatase [Azotobacter vinelandii AvOP], gi\|67085209\|gb... gi\|67157940 - gi\|67157940\|ref\|ZP_00419085.1\| Inorganic diphosphatase [Azotobacter vinelandii AvOP]	281.0	[0..1]	[174..331]
gi\|83631974, gi\|... - gi\|83643931\|ref\|YP_432366.1\| inorganic pyrophosphatase [Hahella chejuensis KCTC 2396], gi\|83631974\|g...	267.0	[0..1]	[173..2]
gi\|115515697, gi... - gi\|117626573\|ref\|YP_859896.1\| inorganic pyrophosphatase [Escherichia coli APEC O1], gi\|115515697\|gb\|... gi\|170021762, gi... - gi\|170021762\|ref\|YP_001726716.1\| inorganic pyrophosphatase [Escherichia coli ATCC 8739], gi\|16975669... gi\|124500731, gi... - gi\|124528289\|ref\|ZP_01699613.1\| Inorganic diphosphatase [Escherichia coli B], gi\|124500731\|gb\|EAY482... gi\|218692615, gi... - gi\|218692615\|ref\|YP_002400827.1\| inorganic pyrophosphatase [Escherichia coli ED1a], gi\|218430179\|emb... gi\|218368156, gi... - gi\|218561387\|ref\|YP_002394300.1\| inorganic pyrophosphatase [Escherichia coli S88], gi\|218368156\|emb\|... gi\|218434933, gi... - gi\|218707836\|ref\|YP_002415355.1\| inorganic pyrophosphatase [Escherichia coli UMN026], gi\|218434933\|e... gi\|218697977, gi... - gi\|218697977\|ref\|YP_002405644.1\| inorganic pyrophosphatase [Escherichia coli 55989], gi\|218354709\|em... IPYR_ECOL6 - Inorganic pyrophosphatase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=ppa PE=3... gi\|75515464, gi\|... - gi\|75515464\|ref\|ZP_00737621.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli 53638], gi\|18849... gi\|110644588, gi... - gi\|110644588\|ref\|YP_672318.1\| inorganic pyrophosphatase [Escherichia coli 536], gi\|110346180\|gb\|ABG7... gi\|193063638, gi... - gi\|75258329\|ref\|ZP_00729760.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli E22], gi\|1930636... gi\|91075354, gi\|... - gi\|91213780\|ref\|YP_543766.1\| inorganic pyrophosphatase [Escherichia coli UTI89], gi\|91075354\|gb\|ABE1... gi\|191170839, gi... - gi\|75242385\|ref\|ZP_00726147.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli F11], gi\|1911708... gi\|75235466, gi\|... - gi\|75235466\|ref\|ZP_00719674.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli E110019], gi\|193... IPYR_ECOL6 - Inorganic pyrophosphatase OS=Escherichia coli O6 GN=ppa PE=3 SV=3 gi\|75229598, gi\|... - gi\|75229598\|ref\|ZP_00716137.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli B7A], gi\|1911672... gi\|194426577, gi... - gi\|75212218\|ref\|ZP_00712258.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli B171], gi\|194426... gi\|157079818, gi... - gi\|75188940\|ref\|ZP_00702207.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli E24377A], gi\|157... gi\|83586744, gi\|... - gi\|83586744\|ref\|ZP_00925376.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli 101-1], gi\|19443... gi\|194417876, gi... - gi\|83569401\|ref\|ZP_00920855.1\| COG0221: Inorganic pyrophosphatase [Shigella dysenteriae 1012], gi\|19... gi\|227836295, gi... - gi\|227886722\|ref\|ZP_04004527.1\| inorganic pyrophosphatase [Escherichia coli 83972], gi\|227836295\|gb\|... gi\|226901812, gi... - gi\|237703900\|ref\|ZP_04534381.1\| inorganic pyrophosphatase [Escherichia sp. 3_2_53FAA], gi\|226901812\|... gi\|251787476, gi... - gi\|251787476\|ref\|YP_003001780.1\| hypothetical protein B21_04059 [Escherichia coli BL21], gi\|24237974... gi\|254290905, gi... - gi\|254290905\|ref\|YP_003056655.1\| inorganic pyrophosphatase [Escherichia coli BL21(DE3)], gi\|25398021... gi\|254037246, gi... - gi\|254037246\|ref\|ZP_04871323.1\| inorganic pyrophosphatase [Escherichia sp. 1_1_43], gi\|226840352\|gb\|... gi\|254164155, gi... - gi\|254164155\|ref\|YP_003047265.1\| inorganic pyrophosphatase [Escherichia coli B str. REL606], gi\|2539...	267.0	[0..1]	[175..2]
gi\|238861510, gi... - gi\|238903331\|ref\|YP_002929127.1\| inorganic pyrophosphatase [Escherichia coli BW2952], gi\|238861510\|g... gi\|254796246, gi... - gi\|254796246\|ref\|YP_003081083.1\| inorganic pyrophosphatase [Escherichia coli O157:H7 str. TW14359], ... gi\|188014807, gi... - gi\|188014807\|gb\|EDU52929.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4113], gi\|16875... gi\|168754802, gi... - gi\|189357767\|gb\|EDU76186.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4401], gi\|16875... gi\|13364681, gi\|... - gi\|15834458\|ref\|NP_313231.1\| inorganic pyrophosphatase [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|168760474, gi... - gi\|189368952\|gb\|EDU87368.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|189364279, gi... - gi\|189364279\|gb\|EDU82698.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4486], gi\|16876... gi\|187770258, gi... - gi\|187770258\|gb\|EDU34102.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|82546525, gi\|... - gi\|82546525\|ref\|YP_410472.1\| inorganic pyrophosphatase [Shigella boydii Sb227], gi\|81247936\|gb\|ABB68... gi\|85676977, gi\|... - gi\|89110946\|ref\|AP_004726.1\| inorganic pyrophosphatase [Escherichia coli str. K-12 substr. W3110], g... gi\|74314704, gi\|... - gi\|74314704\|ref\|YP_313123.1\| inorganic pyrophosphatase [Shigella sonnei Ss046], gi\|73858181\|gb\|AAZ90... gi\|82779485, gi\|... - gi\|82779485\|ref\|YP_405834.1\| inorganic pyrophosphatase [Shigella dysenteriae Sd197], gi\|81243633\|gb\|... gi\|208819390, gi... - gi\|208819390\|ref\|ZP_03259710.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|209396030, gi... - gi\|209396030\|ref\|YP_002273769.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4115], gi\|... gi\|209914981, gi... - gi\|209921722\|ref\|YP_002295806.1\| inorganic pyrophosphatase [Escherichia coli SE11], gi\|209914981\|dbj... gi\|217325669, gi... - gi\|217325669\|ref\|ZP_03441753.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. TW14588], gi\|... gi\|187430491, gi... - gi\|75179327\|ref\|ZP_00699331.1\| COG0221: Inorganic pyrophosphatase [Shigella boydii BS512], gi\|187733... gi\|218556777, gi... - gi\|218556777\|ref\|YP_002389691.1\| inorganic pyrophosphatase [Escherichia coli IAI1], gi\|218363546\|emb... gi\|157163700, gi... - gi\|75198078\|ref\|ZP_00708148.1\| COG0221: Inorganic pyrophosphatase [Escherichia coli HS], gi\|15716370... gi\|188999801, gi... - gi\|188999801\|gb\|EDU68787.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4076], gi\|16878... gi\|168784869, gi... - gi\|189374756\|gb\|EDU93172.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC869], gi\|168784... gi\|189379595, gi... - gi\|189379595\|gb\|EDU98011.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC508], gi\|168797... gi\|170083670, gi... - gi\|170083670\|ref\|YP_001732990.1\| inorganic pyrophosphatase [Escherichia coli str. K-12 substr. DH10B... gi\|170517961, gi... - gi\|170680243\|ref\|YP_001746628.1\| inorganic diphosphatase [Escherichia coli SMS-3-5], gi\|170517961\|gb... gi\|195937253 - gi\|195937253\|ref\|ZP_03082635.1\| inorganic pyrophosphatase [Escherichia coli O157:H7 str. EC4024] gi\|208728786, gi... - gi\|208808985\|ref\|ZP_03251322.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|208733577, gi... - gi\|208812300\|ref\|ZP_03253629.1\| inorganic diphosphatase [Escherichia coli O157:H7 str. EC4045], gi\|2... IPYR_ECOLI - Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) - Escherichia coli EG10755 - inorganic pyrophosphatase / Inorganic pyrophosphatase; binds Zn(II); homohexameric, dimer of trimers IPYR_ECO57 - Inorganic pyrophosphatase OS=Escherichia coli O157:H7 GN=ppa PE=3 SV=2 EG10755 - inorganic pyrophosphatase / Inorganic pyrophosphatase; binds Zn(II); homohexameric, dimer of trimers gi\|15804817, gi\|... - gi\|15804817\|ref\|NP_290858.1\| inorganic pyrophosphatase [Escherichia coli O157:H7 EDL933], gi\|1251922...	266.0	[0..1]	[175..2]
gi\|2781253, gi\|2... - gi\|2781253\|pdb\|1MJX\|B Chain B, Structure Of Inorganic Pyrophosphatase Mutant D65n, gi\|2781252\|pdb\|1M...	264.0	[0..1]	[175..1]
gi\|109896471, gi... - gi\|76792190\|ref\|ZP_00774692.1\| Inorganic diphosphatase [Pseudoalteromonas atlantica T6c], gi\|7659262...	264.0	[0..1]	[175..2]
gi\|77973992, gi\|... - gi\|77973992\|ref\|ZP_00829535.1\| COG0221: Inorganic pyrophosphatase [Yersinia frederiksenii ATCC 33641... gi\|162421500, gi... - gi\|77634763\|ref\|ZP_00796857.1\| COG0221: Inorganic pyrophosphatase [Yersinia pestis Angola], gi\|16242... gi\|117675055, gi... - gi\|77631453\|ref\|ZP_00794039.1\| COG0221: Inorganic pyrophosphatase [Yersinia pseudotuberculosis IP 31... gi\|165937420, gi... - gi\|89104090\|ref\|ZP_01176644.1\| COG0221: Inorganic pyrophosphatase [Yersinia pestis biovar Orientalis... gi\|108806069, gi... - gi\|108806069\|ref\|YP_649985.1\| inorganic pyrophosphatase [Yersinia pestis Antiqua], gi\|108777982\|gb\|A... gi\|149288935, gi... - gi\|153997298\|ref\|ZP_02022398.1\| inorganic pyrophosphatase [Yersinia pestis CA88-4125], gi\|149288935\|... Q66F85\|Q66F85_YERPS - Inorganic pyrophosphatase - Yersinia pseudotuberculosis gi\|145212513, gi... - gi\|145600817\|ref\|YP_001164893.1\| inorganic pyrophosphatase [Yersinia pestis Pestoides F], gi\|1452125... gi\|108777073, gi... - gi\|229903901\|ref\|ZP_04519014.1\| inorganic pyrophosphatase [Yersinia pestis Nepal516], gi\|229679671\|g... gi\|166961475, gi... - gi\|167420669\|ref\|ZP_02312422.1\| inorganic pyrophosphatase [Yersinia pestis biovar Orientalis str. MG... gi\|167401256, gi... - gi\|167401256\|ref\|ZP_02306756.1\| inorganic pyrophosphatase [Yersinia pestis biovar Antiqua str. UG05-... gi\|167469959 - gi\|167469959\|ref\|ZP_02334663.1\| inorganic pyrophosphatase [Yersinia pestis FV-1] gi\|167423772, gi... - gi\|167423772\|ref\|ZP_02315525.1\| inorganic pyrophosphatase [Yersinia pestis biovar Mediaevalis str. K... gi\|186893816, gi... - gi\|186893816\|ref\|YP_001870928.1\| inorganic pyrophosphatase [Yersinia pseudotuberculosis PB1/+], gi\|1... gi\|170025982, gi... - gi\|170025982\|ref\|YP_001722487.1\| inorganic pyrophosphatase [Yersinia pseudotuberculosis YPIII], gi\|1... gi\|229695541, gi... - gi\|229839175\|ref\|ZP_04459334.1\| inorganic pyrophosphatase [Yersinia pestis biovar Orientalis str. PE... gi\|229700442, gi... - gi\|229896664\|ref\|ZP_04511831.1\| inorganic pyrophosphatase [Yersinia pestis Pestoides A], gi\|22970044... gi\|229687231, gi... - gi\|229899739\|ref\|ZP_04514880.1\| inorganic pyrophosphatase [Yersinia pestis biovar Orientalis str. In... gi\|122087750, gi... - gi\|123440789\|ref\|YP_001004780.1\| inorganic pyrophosphatase [Yersinia enterocolitica subsp. enterocol... gi\|165928155, gi... - gi\|165928155\|ref\|ZP_02223987.1\| inorganic pyrophosphatase [Yersinia pestis biovar Orientalis str. F1... gi\|166204794, gi... - gi\|166213999\|ref\|ZP_02240034.1\| inorganic pyrophosphatase [Yersinia pestis biovar Antiqua str. B4200... gi\|165989700, gi... - gi\|166011316\|ref\|ZP_02232214.1\| inorganic pyrophosphatase [Yersinia pestis biovar Antiqua str. E1979... gi\|22124577, gi\|... - gi\|22124577\|ref\|NP_668000.1\| inorganic pyrophosphatase [Yersinia pestis KIM], gi\|21957379\|gb\|AAM8425... gi\|51594807, gi\|... - gi\|51594807\|ref\|YP_068998.1\| inorganic pyrophosphatase [Yersinia pseudotuberculosis IP 32953], gi\|51... gi\|45435273, gi\|... - gi\|45440416\|ref\|NP_991955.1\| inorganic pyrophosphatase [Yersinia pestis biovar Microtus str. 91001],... gi\|115349146, gi... - gi\|218930535\|ref\|YP_002348410.1\| inorganic pyrophosphatase [Yersinia pestis CO92], gi\|16123667\|ref\|N... IPYR_YERPE - Inorganic pyrophosphatase OS=Yersinia pestis GN=ppa PE=3 SV=1	264.0	[0..1]	[174..2]
gi\|56480564, gi\|... - gi\|56480564\|ref\|NP_709975.2\| inorganic pyrophosphatase [Shigella flexneri 2a str. 301], gi\|56384115\|... gi\|30065484, gi\|... - gi\|30065484\|ref\|NP_839655.1\| inorganic pyrophosphatase [Shigella flexneri 2a str. 2457T], gi\|3004374... gi\|110808031, gi... - gi\|110808031\|ref\|YP_691551.1\| inorganic pyrophosphatase [Shigella flexneri 5 str. 8401], gi\|11061757...	264.0	[0..1]	[175..2]

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Predicted Domain #1

Region A:
Residues: [1-175]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLLNVPAGKD LPEDIYVVIE IPANADPIKY EIDKESGALF VDRFMSTAMF YPCNYGYINH  60
   61 TLSLDGDPVD VLVPTPYPLQ PGSVIRCRPV GVLKMTDEAG EDAKLVAVPH SKLSKEYDHI 120
  121 KDVNDLPELL KAQIAHFFEH YKDLEKGKWV KVEGWENAEA AKAEIVASFE RAKNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.69897
Match:	1fajA
Description:	INORGANIC PYROPHOSPHATASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
inorganic diphosphatase activity	2.74116819406619	bayes_pls_golite062009
catalytic activity	1.33262120571864	bayes_pls_golite062009
binding	0.737012988130381	bayes_pls_golite062009
hydrolase activity	0.622613523623213	bayes_pls_golite062009
protein binding	0.30018672253552	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.130183342564216	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.129135337748915	bayes_pls_golite062009
pyrophosphatase activity	0.125429411374269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: