YRC Public Data Repository - Protein Structure Prediction

Protein:	LGUL_ECOLI
Organism:	Escherichia coli
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LGUL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|150841188, gi... - gi\|75431428\|ref\|ZP_00733000.1\| Lactoylglutathione lyase [Actinobacillus succinogenes 130Z], gi\|74276...	149.0	[0..1]	[135..1]
gi\|110343365, gi... - gi\|110641773\|ref\|YP_669503.1\| glyoxalase I [Escherichia coli 536], gi\|110343365\|gb\|ABG69602.1\| lacto... gi\|117623835, gi... - gi\|117623835\|ref\|YP_852748.1\| glyoxalase I [Escherichia coli APEC O1], gi\|115512959\|gb\|ABJ01034.1\| l... gi\|227837110, gi... - gi\|227885931\|ref\|ZP_04003736.1\| Lactoylglutathione lyase [Escherichia coli 83972], gi\|227837110\|gb\|E... gi\|237705596, gi... - gi\|237705596\|ref\|ZP_04536077.1\| lactoylglutathione lyase [Escherichia sp. 3_2_53FAA], gi\|226900353\|g... gi\|75238789, gi\|... - gi\|75238789\|ref\|ZP_00722773.1\| COG0346: Lactoylglutathione lyase and related lyases [Escherichia col... gi\|91210865, gi\|... - gi\|91210865\|ref\|YP_540851.1\| glyoxalase I [Escherichia coli UTI89], gi\|91072439\|gb\|ABE07320.1\| lacto... gi\|26108302, gi\|... - gi\|26247899\|ref\|NP_753939.1\| glyoxalase I [Escherichia coli CFT073], gi\|26108302\|gb\|AAN80504.1\|AE016... gi\|194434721, gi... - gi\|194434721\|ref\|ZP_03066974.1\| lactoylglutathione lyase [Shigella dysenteriae 1012], gi\|194417059\|g... gi\|170768683, gi... - gi\|170768683\|ref\|ZP_02903136.1\| lactoylglutathione lyase [Escherichia albertii TW07627], gi\|17012223... gi\|218427161, gi... - gi\|218689597\|ref\|YP_002397809.1\| glyoxalase I [Escherichia coli ED1a], gi\|218427161\|emb\|CAR08044.2\| ... gi\|218365291, gi... - gi\|218558522\|ref\|YP_002391435.1\| glyoxalase I [Escherichia coli S88], gi\|218365291\|emb\|CAR03012.1\| g...	149.0	[0..1]	[135..1]
gi\|157080414, gi... - gi\|75190690\|ref\|ZP_00703957.1\| COG0346: Lactoylglutathione lyase and related lyases [Escherichia col...	148.0	[0..1]	[135..1]
gi\|214000294 - gi\|214000294\|ref\|ZP_03411029.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... gi\|224468583, gi... - gi\|224584056\|ref\|YP_002637854.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serov... gi\|213426002 - gi\|213426002\|ref\|ZP_03358752.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... gi\|213586462 - gi\|213586462\|ref\|ZP_03368288.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... gi\|213649690 - gi\|213649690\|ref\|ZP_03379743.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... gi\|213855186 - gi\|213855186\|ref\|ZP_03383426.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... lcl\|NC_016856.1_... - [gene=gloA] [protein=glyoxalase I] [protein_id=YP_005237305.1] [location=complement(1522426..1522833... gi\|238913164 - gi\|238913164\|ref\|ZP_04657001.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Tennessee ... gi\|161614146, gi... - gi\|161614146\|ref\|YP_001588111.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Paratyphi... gi\|167551595, gi... - gi\|205323627\|gb\|EDZ11466.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar Sa... gi\|205327837, gi... - gi\|205327837\|gb\|EDZ14601.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar 4,... gi\|205335477, gi... - gi\|205335477\|gb\|EDZ22241.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar Ke... LGUL_SALTI - Lactoylglutathione lyase OS=Salmonella typhi GN=gloA PE=3 SV=1 LGUL_SALTY - Lactoylglutathione lyase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=gloA PE=... LGUL_SALTI - Lactoylglutathione lyase OS=Salmonella typhi GN=gloA PE=3 SV=1 gi\|29137390, gi\|... - gi\|29141762\|ref\|NP_805104.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str. Ty... LGUL_SALTY - Lactoylglutathione lyase OS=Salmonella typhimurium GN=gloA PE=3 SV=1 gi\|16760478 - gi\|16760478\|ref\|NP_456095.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str. CT... gi\|204927822, gi... - gi\|204927822\|ref\|ZP_03219023.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serova... gi\|205352851, gi... - gi\|205352851\|ref\|YP_002226652.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Gallinaru... gi\|207857061, gi... - gi\|207857061\|ref\|YP_002243712.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Enteritid... gi\|213161995 - gi\|213161995\|ref\|ZP_03347705.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Typhi str.... gi\|197242941, gi... - gi\|197264686\|ref\|ZP_03164760.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serova... gi\|197093997, gi... - gi\|197362520\|ref\|YP_002142157.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Paratyphi... gi\|197939586, gi... - gi\|198245070\|ref\|YP_002215699.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serov... gi\|199603158, gi... - gi\|200390713\|ref\|ZP_03217324.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serova... gi\|194404801, gi... - gi\|194446138\|ref\|YP_002040684.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serov... gi\|194407120, gi... - gi\|194448816\|ref\|YP_002045473.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Heidelber... gi\|194469570, gi... - gi\|194469570\|ref\|ZP_03075554.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serova... gi\|197250838, gi... - gi\|197250838\|ref\|YP_002146610.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serov... LGUL_SALTY - Lactoylglutathione lyase OS=Salmonella typhimurium GN=gloA PE=3 SV=1 gi\|205339700, gi... - gi\|205339700\|gb\|EDZ26464.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar He... gi\|205346857, gi... - gi\|205346857\|gb\|EDZ33488.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar Ha... gi\|62180024, gi\|... - gi\|62180024\|ref\|YP_216441.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Choleraesuis ... gi\|168463154, gi... - gi\|195634070\|gb\|EDX52422.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar Ne... gi\|56127853, gi\|... - gi\|56413596\|ref\|YP_150671.1\| glyoxalase I [Salmonella enterica subsp. enterica serovar Paratyphi A s... gi\|205343626, gi... - gi\|205343626\|gb\|EDZ30390.1\| lactoylglutathione lyase [Salmonella enterica subsp. enterica serovar We...	147.0	[0..1]	[135..1]
gi\|187731273, gi... - gi\|75178453\|ref\|ZP_00698499.1\| COG0346: Lactoylglutathione lyase and related lyases [Shigella boydii... gi\|81245394, gi\|... - gi\|82543983\|ref\|YP_407930.1\| glyoxalase I [Shigella boydii Sb227], gi\|81245394\|gb\|ABB66102.1\| lactoy...	147.0	[0..1]	[135..1]
gi\|15602852, gi\|... - gi\|15602852\|ref\|NP_245924.1\| hypothetical protein PM0987 [Pasteurella multocida subsp. multocida str... tr\|J6CVB7\|J6CVB7... - Lactoylglutathione lyase OS=Pasteurella multocida subsp. multocida str. Anand1_cattle GN=AAUPMC_1045...	146.0	[0..1]	[135..1]
gi\|227081184, gi... - gi\|227081184\|ref\|YP_002809735.1\| lactoylglutathione lyase [Vibrio cholerae M66-2], gi\|227009072\|gb\|A... gi\|153829533, gi... - gi\|153829533\|ref\|ZP_01982200.1\| lactoylglutathione lyase [Vibrio cholerae 623-39], gi\|148874993\|gb\|E... gi\|229350904, gi... - gi\|229510939\|ref\|ZP_04400418.1\| lactoylglutathione lyase [Vibrio cholerae B33], gi\|229350904\|gb\|EEO1... gi\|229515396, gi... - gi\|229515396\|ref\|ZP_04404855.1\| lactoylglutathione lyase [Vibrio cholerae TMA 21], gi\|229347165\|gb\|E... gi\|9655474, gi\|1... - gi\|9655474\|gb\|AAF94171.1\| lactoylglutathione lyase [Vibrio cholerae O1 biovar El Tor str. N16961], g... gi\|227012827, gi... - gi\|227117377\|ref\|YP_002819273.1\| lactoylglutathione lyase [Vibrio cholerae O395], gi\|227012827\|gb\|AC... gi\|229357614, gi... - gi\|229505391\|ref\|ZP_04394901.1\| lactoylglutathione lyase [Vibrio cholerae BX 330286], gi\|229357614\|g... gi\|254843845, gi... - gi\|254848140\|ref\|ZP_05237490.1\| lactoylglutathione lyase [Vibrio cholerae MO10], gi\|254843845\|gb\|EET... gi\|229344775, gi... - gi\|229518060\|ref\|ZP_04407504.1\| lactoylglutathione lyase [Vibrio cholerae RC9], gi\|229344775\|gb\|EEO0... gi\|121628268, gi... - gi\|121729982\|ref\|ZP_01682399.1\| lactoylglutathione lyase [Vibrio cholerae V52], gi\|121628268\|gb\|EAX6... gi\|229371065, gi... - gi\|229608410\|ref\|YP_002879058.1\| lactoylglutathione lyase [Vibrio cholerae MJ-1236], gi\|229371065\|gb... LGUL_VIBCH - (Q9KT93) Probable lactoylglutathione lyase (EC 4.4.1.5) (Methylglyoxalase) (Aldoketomutase) (Glyoxal...	146.0	[0..2]	[133..51]
gi\|71669193, gi\|... - gi\|71677562\|ref\|ZP_00675298.1\| Glyoxalase I [Trichodesmium erythraeum IMS101], gi\|71669193\|gb\|EAO258...	146.0	[0..1]	[127..1]
gi\|7467271, gi\|1... - pir\|\|JC6313 lactoylglutathione lyase (EC 4.4.1.5) [validated] - Salmonella typhimurium, gi\|1354847\|g... gi\|1354847\|gb\|AA... - S-D-lactolyglutathione methylglyoxal lyase	146.0	[0..1]	[135..1]
gi\|52306810, gi\|... - gi\|52424758\|ref\|YP_087895.1\| GloA protein [Mannheimia succiniciproducens MBEL55E], gi\|52306810\|gb\|AA...	145.0	[0..1]	[135..2]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLHTMLRV GDLQRSIDFY TKVLGMKLLR TSENPEYKYS LAFVGYGPET EEAVIELTYN  60
   61 WGVDKYELGT AYGHIALSVD NAAEACEKIR QNGGNVTREA GPVKGGTTVI AFVEDPDGYK 120
  121 IELIEEKDAG RGLGN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.522879
Match:	1f9zA
Description:	Glyoxalase I (lactoylglutathione lyase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lactoylglutathione lyase activity	3.91334658149719	bayes_pls_golite062009
carbon-sulfur lyase activity	1.44168339433372	bayes_pls_golite062009
catalytic activity	1.21778090213032	bayes_pls_golite062009
binding	0.78394104122898	bayes_pls_golite062009
protein binding	0.0335467332601391	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: