YRC Public Data Repository - Protein Structure Prediction

Protein:	METB_ECOLI
Organism:	Escherichia coli
Length:	386 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75910353, gi\|... - gi\|75910353\|ref\|YP_324649.1\| cystathionine gamma-lyase [Anabaena variabilis ATCC 29413], gi\|75704078...	417.0	[0..3]	[381..1]
gi\|28204552, gi\|... - gi\|28212109\|ref\|NP_783053.1\| methionine gamma-lyase [Clostridium tetani E88], gi\|28204552\|gb\|AAO3699...	415.0	[0..2]	[385..5]
gi\|85829762, gi\|... - gi\|86143719\|ref\|ZP_01062095.1\| Cystathionine gamma-synthase [Flavobacterium sp. MED217], gi\|85829762... gi\|85829762, gi\|... - gi\|86143719\|ref\|ZP_01062095.1\| Cystathionine gamma-synthase [Flavobacterium sp. MED217], gi\|85829762...	399.0	[0..3]	[381..1]
gi\|89889968, gi\|... - gi\|89889968\|ref\|ZP_01201479.1\| cystathionine beta-lyase [Flavobacteria bacterium BBFL7], gi\|89518241...	399.0	[0..3]	[381..6]
gi\|90590715, gi\|... - gi\|90590715\|ref\|ZP_01246361.1\| Cystathionine gamma-synthase [Flavobacterium johnsoniae UW101], gi\|90...	398.0	[0..3]	[381..1]
gi\|28883481 - gi\|28883481\|gb\|AAO46884.1\| methionine gamma-lyase [Citrobacter freundii]	398.0	[0..2]	[383..6]
gi\|108763360, gi... - gi\|108763360\|ref\|YP_630264.1\| Cys/Met metabolism PLP-dependent enzyme [Myxococcus xanthus DK 1622], ...	397.0	[0..3]	[384..1]
gi\|89210477, gi\|... - gi\|89210477\|ref\|ZP_01188866.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Halothermothrix oren...	396.0	[0..3]	[380..9]
gi\|21698926 - gi\|21698926\|dbj\|BAC02724.1\| L-methionine-alpha-deamino-gamma- mercaptomethane-lyase [Fusobacterium n... MEGL_FUSNP - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. polymorphum GN=mgl PE=1 SV=1 gi\|197737499, gi... - gi\|254304388\|ref\|ZP_04971746.1\| methionine gamma-lyase [Fusobacterium nucleatum subsp. polymorphum A...	395.0	[0..2]	[383..5]

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Predicted Domain #1

Region A:
Residues: [1-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA  60
   61 LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL 120
  121 FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA 180
  181 LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL 240
  241 LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML 300
  301 SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL 360
  361 RISTGIEDGE DLIADLENGF RAANKG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	99.0
Match:	1cs1A
Description:	Cystathionine gamma-synthase, CGS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	2.82824364293374	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	2.82824364293374	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.994935084630764	bayes_pls_golite062009
ligase activity	0.827063849687833	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
cystathionine beta-lyase activity	0.6849039330512	bayes_pls_golite062009
vitamin binding	0.66463470119531	bayes_pls_golite062009
cystathionine gamma-lyase activity	0.505859361763689	bayes_pls_golite062009
alanine-glyoxylate transaminase activity	0.48682493494502	bayes_pls_golite062009
O-acyltransferase activity	0.452440867878365	bayes_pls_golite062009
cysteine synthase activity	0.417849187928985	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	0.0669652799570574	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: