YRC Public Data Repository - Protein Structure Prediction

Protein:	NADD_ECOLI
Organism:	Escherichia coli
Length:	213 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NADD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91071261, gi\|... - gi\|91209687\|ref\|YP_539673.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli UTI... gi\|26107019, gi\|... - gi\|26246620\|ref\|NP_752660.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli CFT...	216.0	[0..1]	[213..22]
NADD_SALTY - Nicotinate-nucleotide adenylyltransferase OS=Salmonella typhimurium GN=nadD PE=3 SV=1 NADD_SALCH - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella choleraesuis GN=nadD PE=3 SV=1 NADD_SALPB - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 /... NADD_SALTY - Nicotinate-nucleotide adenylyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 70... NADD_SALPA - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella paratyphi A GN=nadD PE=3 SV=1 NADD_SALAR - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella arizonae (strain ATCC BAA-731 / CDC... NADD_SALTY - Nicotinate-nucleotide adenylyltransferase OS=Salmonella typhimurium GN=nadD PE=3 SV=1 NADD_SALCH - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella choleraesuis GN=nadD PE=3 SV=1 NADD_SALCH - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella choleraesuis (strain SC-B67) GN=nad... NADD_SALPA - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella paratyphi A (strain ATCC 9150 / SAR... NADD_SALPB - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 /... lcl\|NC_016856.1_... - [gene=nadD] [protein=nicotinic acid mononucleotide adenylyltransferase] [protein_id=YP_005236361.1] ... gi\|194457210, gi... - gi\|194470846\|ref\|ZP_03076830.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Salmonella... gi\|205360775, gi... - gi\|205360775\|ref\|ZP_02686395.2\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Salmonella... gi\|205357571, gi... - gi\|205357571\|ref\|ZP_02571754.2\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Salmonella... NADD_SALPK - Probable nicotinate-nucleotide adenylyltransferase OS=Salmonella paratyphi A (strain AKU_12601) GN=n...	215.0	[0..1]	[213..1]
gi\|237707387, gi... - gi\|237707387\|ref\|ZP_04537868.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia sp. 3... NADD_ECO45 - Probable nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) G... gi\|227884381, gi... - gi\|227884381\|ref\|ZP_04002186.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli ... gi\|75237601, gi\|... - gi\|75237601\|ref\|ZP_00721632.1\| COG1057: Nicotinic acid mononucleotide adenylyltransferase [Escherich... NADD_ECOK1 - Probable nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O1:K1 / APEC GN=nadD PE=3 SV=... NADD_ECOL5 - Probable nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC... NADD_ECOL6 - Nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O6 GN=nadD PE=3 SV=2 NADD_ECOL6 - Nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / U...	214.0	[0..1]	[213..1]
gi\|208728025, gi... - gi\|208808224\|ref\|ZP_03250561.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichi... gi\|208816101, gi... - gi\|208816101\|ref\|ZP_03257280.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichi... gi\|208823074, gi... - gi\|208823074\|ref\|ZP_03263392.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichi... gi\|15829931, gi\|... - gi\|15829931\|ref\|NP_308704.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli O15... NADD_ECO5E - Probable nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC... gi\|168779132, gi... - gi\|189002738\|gb\|EDU71724.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|189373692, gi... - gi\|189373692\|gb\|EDU92108.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|189375557, gi... - gi\|189375557\|gb\|EDU93973.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|195939379 - gi\|195939379\|ref\|ZP_03084761.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli ... gi\|254591205, gi... - gi\|254791805\|ref\|YP_003076642.1\| nicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent... gi\|168758284, gi... - gi\|189354873\|gb\|EDU73292.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|189365365, gi... - gi\|189365365\|gb\|EDU83781.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|168767087, gi... - gi\|189363504\|gb\|EDU81923.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... gi\|168777618, gi... - gi\|187767180\|gb\|EDU31024.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichia co... NADD_ECO57 - Nicotinate-nucleotide adenylyltransferase OS=Escherichia coli O157:H7 GN=nadD PE=3 SV=1 gi\|15800353, gi\|... - gi\|15800353\|ref\|NP_286365.1\| nicotinic acid mononucleotide adenylyltransferase [Escherichia coli O15... gi\|25306179, gi\|... - pir\|\|A85564 hypothetical protein ybeN [imported] - Escherichia coli (strain O157:H7, substrain EDL9... NADD_SHIDS - Probable nicotinate-nucleotide adenylyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197)... gi\|217321622, gi... - gi\|217325401\|ref\|ZP_03441485.1\| nicotinate (nicotinamide) nucleotide adenylyltransferase [Escherichi...	214.0	[0..1]	[213..1]
gi\|83569090, gi\|... - gi\|83569090\|ref\|ZP_00920550.1\| COG1057: Nicotinic acid mononucleotide adenylyltransferase [Shigella ...	214.0	[0..1]	[213..1]
NADD_SHIB3 - Probable nicotinate-nucleotide adenylyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-9...	214.0	[0..1]	[213..1]
NADD_SALTI - Nicotinate-nucleotide adenylyltransferase OS=Salmonella typhi GN=nadD PE=3 SV=1 NADD_SALTI - Nicotinate-nucleotide adenylyltransferase OS=Salmonella typhi GN=nadD PE=3 SV=1 gi\|29142623, gi\|... - gi\|29142623\|ref\|NP_805965.1\| nicotinic acid mononucleotide adenylyltransferase [Salmonella enterica ... gi\|16759604 - gi\|16759604\|ref\|NP_455221.1\| nicotinic acid mononucleotide adenylyltransferase [Salmonella enterica ...	213.0	[0..1]	[213..1]
NADD_SHIBS - Probable nicotinate-nucleotide adenylyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=n...	212.0	[0..1]	[213..1]
NADD_ERWCT - Probable nicotinate-nucleotide adenylyltransferase OS=Erwinia carotovora subsp. atroseptica GN=nadD ... NADD_PECAS - Probable nicotinate-nucleotide adenylyltransferase OS=Pectobacterium atrosepticum (strain SCRI 1043 ...	211.0	[0..1]	[213..1]
gi\|77973034 - gi\|77973034\|ref\|ZP_00828587.1\| COG1057: Nicotinic acid mononucleotide adenylyltransferase [Yersinia ...	209.0	[0..2]	[213..8]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLQALFGG TFDPVHYGHL KPVETLANLI GLTRVTIIPN NVPPHRPQPE ANSVQRKHML  60
   61 ELAIADKPLF TLDERELKRN APSYTAQTLK EWRQEQGPDV PLAFIIGQDS LLTFPTWYEY 120
  121 ETILDNAHLI VCRRPGYPLE MAQPQYQQWL EDHLTHNPED LHLQPAGKIY LAETPWFNIS 180
  181 ATIIRERLQN GESCEDLLPE PVLTYINQQG LYR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.0
Match:	1k4kA
Description:	Nicotinamide mononucleotide (NMN) adenylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate-nucleotide adenylyltransferase activity	2.83520682135534	bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity	2.57110502211876	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	2.54008423253828	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	2.54008423253828	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	2.52910114154477	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
ligase activity	1.92894388839884	bayes_pls_golite062009
adenylyltransferase activity	1.08055019963499	bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity	0.454904507512502	bayes_pls_golite062009
pantoate-beta-alanine ligase activity	0.282286652169846	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: