YRC Public Data Repository - Protein Structure Prediction

Protein:	PGP_PYRHO
Organism:	Pyrococcus horikoshii
Length:	231 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGP_PYRHO.

Description	E-value	Query Range	Subject Range
gi\|10173110, gi\|... - gi\|15613060\|ref\|NP_241363.1\| hypothetical protein BH0497 [Bacillus halodurans C-125], gi\|10173110\|db... gi\|25303665 - pir\|\|A83712 hypothetical protein BH0497 [imported] - Bacillus halodurans (strain C-125)	167.0	[0..3]	[226..5]
gi\|52078942, gi\|... - gi\|52784317\|ref\|YP_090146.1\| YcsE [Bacillus licheniformis ATCC 14580], gi\|52346819\|gb\|AAU39453.1\| Yc...	165.0	[0..2]	[226..10]
gi\|182379797, gi... - gi\|182379797\|gb\|EDT77276.1\| HAD hydrolase, IIB family [Clostridium perfringens NCTC 8239], gi\|168218... gi\|110674966, gi... - gi\|110800319\|ref\|YP_695962.1\| HAD family hydrolase [Clostridium perfringens ATCC 13124], gi\|11067496...	160.0	[0..1]	[229..1]
gi\|29340667, gi\|... - gi\|29348761\|ref\|NP_812264.1\| haloacid dehalogenase-like hydrolase [Bacteroides thetaiotaomicron VPI-...	158.0	[0..1]	[227..1]
gi\|22778222, gi\|... - gi\|23099991\|ref\|NP_693457.1\| hypothetical protein OB2536 [Oceanobacillus iheyensis HTE831], gi\|22778...	158.0	[0..2]	[224..6]
gi\|221312544 - gi\|221312544\|ref\|ZP_03594349.1\| hypothetical protein BsubsN3_02279 [Bacillus subtilis subsp. subtili... YCSE_BACSU - Uncharacterized protein ycsE OS=Bacillus subtilis GN=ycsE PE=3 SV=1 gi\|16077472, gi\|... - gi\|2632705\|emb\|CAB12212.1\| ycsE [Bacillus subtilis subsp. subtilis str. 168], gi\|16077472\|ref\|NP_388...	155.0	[0..2]	[226..9]
gi\|89097963, gi\|... - gi\|89097963\|ref\|ZP_01170850.1\| YcsE [Bacillus sp. NRRL B-14911], gi\|89087465\|gb\|EAR66579.1\| YcsE [Ba...	155.0	[0..3]	[229..10]
gi\|52214354, gi\|... - gi\|53711489\|ref\|YP_097481.1\| haloacid dehalogenase-like hydrolase [Bacteroides fragilis YCH46], gi\|5...	155.0	[0..1]	[225..1]
gi\|114336759, gi... - gi\|71542317\|ref\|ZP_00663955.1\| Cof protein:HAD-superfamily hydrolase, subfamily IIB [Syntrophomonas ...	154.0	[0..1]	[226..1]
gi\|25303664 - pir\|\|H96985 probable hydrolase of the HAD superfamily [imported] - Clostridium acetobutylicum gi\|15893986, gi\|... - gi\|15893986\|ref\|NP_347335.1\| HAD superfamily hydrolase [Clostridium acetobutylicum ATCC 824], gi\|150...	154.0	[0..1]	[225..1]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIKAISIDI DGTITYPNRM IHEKALEAIR RAESLGIPIM LVTGNTVQFA EAASILIGTS  60
   61 GPVVAEDGGA ISYKKKRIFL ASMDEEWILW NEIRKRFPNA RTSYTMPDRR AGLVIMRETI 120
  121 NVETVREIIN ELNLNLVAVD SGFAIHVKKP WINKGSGIEK ASEFLGIKPK EVAHVGDGEN 180
  181 DLDAFKVVGY KVAVAQAPKI LKENADYVTK KEYGEGGAEA IYHILEKFGY L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.522879
Match:	1wr8A
Description:	Crystal structure of hypothetical protein PH1421 from Pyrococcus horikoshii.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.02290994020378	bayes_pls_golite062009
hydrolase activity	0.71914501009647	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: