YRC Public Data Repository - Protein Structure Prediction

Protein:	YFIF_ECOLI
Organism:	Escherichia coli
Length:	345 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFIF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|30063982, gi\|... - gi\|30063982\|ref\|NP_838153.1\| putative methyltransferase [Shigella flexneri 2a str. 2457T], gi\|300422...	286.0	[0..1]	[345..1]
gi\|110806525, gi... - gi\|110806525\|ref\|YP_690045.1\| putative methyltransferase [Shigella flexneri 5 str. 8401], gi\|1106160...	285.0	[0..1]	[345..1]
gi\|81246447, gi\|... - gi\|82545036\|ref\|YP_408983.1\| putative methyltransferase [Shigella boydii Sb227], gi\|81246447\|gb\|ABB6...	284.0	[0..1]	[345..1]
gi\|75513191 - gi\|75513191\|ref\|ZP_00735633.1\| COG0566: rRNA methylases [Escherichia coli 53638] gi\|75258006 - gi\|75258006\|ref\|ZP_00729480.1\| COG0566: rRNA methylases [Escherichia coli E22] gi\|75237673 - gi\|75237673\|ref\|ZP_00721689.1\| COG0566: rRNA methylases [Escherichia coli E110019] gi\|75209514 - gi\|75209514\|ref\|ZP_00709739.1\| COG0566: rRNA methylases [Escherichia coli B171] gi\|75196600 - gi\|75196600\|ref\|ZP_00706670.1\| COG0566: rRNA methylases [Escherichia coli HS] gi\|75178187 - gi\|75178187\|ref\|ZP_00698246.1\| COG0566: rRNA methylases [Shigella boydii BS512] gi\|83586767 - gi\|83586767\|ref\|ZP_00925398.1\| COG0566: rRNA methylases [Escherichia coli 101-1]	283.0	[0..1]	[345..26]
gi\|15803108, gi\|... - gi\|15803108\|ref\|NP_289139.1\| putative methyltransferase [Escherichia coli O157:H7 EDL933], gi\|125170... gi\|25325044 - gi\|25325044\|pir\|\|E85904 hypothetical protein yfiF [imported] - Escherichia coli (strain O157:H7, su...	283.0	[0..1]	[345..1]
gi\|227835967, gi... - gi\|227887617\|ref\|ZP_04005422.1\| methyltransferase [Escherichia coli 83972], gi\|227835967\|gb\|EEJ46433... gi\|110642743, gi... - gi\|110642743\|ref\|YP_670473.1\| putative methyltransferase [Escherichia coli 536], gi\|110344335\|gb\|ABG... gi\|191174012, gi... - gi\|191174012\|ref\|ZP_03035529.1\| RNA methyltransferase, TrmH family [Escherichia coli F11], gi\|190905...	283.0	[0..1]	[345..1]
gi\|83570818 - gi\|83570818\|ref\|ZP_00922261.1\| COG0566: rRNA methylases [Shigella dysenteriae 1012]	282.0	[0..1]	[345..26]
gi\|75228844 - gi\|75228844\|ref\|ZP_00715445.1\| COG0566: rRNA methylases [Escherichia coli B7A] gi\|75187334 - gi\|75187334\|ref\|ZP_00700601.1\| COG0566: rRNA methylases [Escherichia coli E24377A]	282.0	[0..1]	[345..26]
gi\|56383696, gi\|... - gi\|56480145\|ref\|NP_708432.2\| putative methyltransferase [Shigella flexneri 2a str. 301], gi\|56383696...	281.0	[0..1]	[345..1]
gi\|237705091, gi... - gi\|237705091\|ref\|ZP_04535572.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|91073482, gi\|... - gi\|91211908\|ref\|YP_541894.1\| putative methyltransferase [Escherichia coli UTI89], gi\|91073482\|gb\|ABE...	281.0	[0..1]	[345..26]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDEMKGKSG KVKVMYVRSD DDSDKRTHNP RTGKGGGRPG KSRADGGRRP ARDDKQSQPR  60
   61 DRKWEDSPWR TVSRAPGDET PEKADHGGIS GKSFI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [96-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPEVLRRQRA EETRVYGENA CQALFQSRPE AIVRAWFIQS VTPRFKEALR WMAANRKAYH  60
   61 VVDEAELTKA SGTEHHGGVC FLIKKRNGTT VQQWVSQAGA QDCVLALENE SNPHNLGGMM 120
  121 RSCAHFGVKG VVVQDAALLE SGAAIRTAEG GAEHVQPITG DNIVNVLDDF RQAGYTVVTT 180
  181 SSEQGKPLFK TSLPAKMVLV LGQEYEGLPD AARDPNDLRV KIDGTGNVAG LNISVATGVL 240
  241 LGEWWRQNKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.39794
Match:	1gz0A
Description:	RlmB, C-terminal domain; RlmB, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA methyltransferase activity	4.77771076540343	bayes_pls_golite062009
methyltransferase activity	4.0901595540349	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.01958090893547	bayes_pls_golite062009
rRNA methyltransferase activity	3.659149846946	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.59156540645412	bayes_pls_golite062009
tRNA methyltransferase activity	2.52700462137917	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	2.29844424181442	bayes_pls_golite062009
tRNA (guanine-N1-)-methyltransferase activity	2.0947794364355	bayes_pls_golite062009
transferase activity	1.84002196534744	bayes_pls_golite062009
catalytic activity	1.16774040077235	bayes_pls_golite062009
rRNA (guanosine-2'-O-)-methyltransferase activity	0.778889412216451	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.47764353619615	bayes_pls_golite062009
N-methyltransferase activity	0.0655574594365502	bayes_pls_golite062009
structural constituent of ribosome	0.0643795631250501	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: