YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: APBA1
Organism: Homo sapiens
Length: 837 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APBA1.

Description E-value Query
Range		 Subject
Range
sp|Q02410|APBA1_... - Amyloid beta A4 precursor protein-binding family A member 1 OS=Homo sapiens GN=APBA1 PE=1 SV=3 VAR_0...
gi|114624954, gi... - gi|114624954|ref|XP_001138890.1| PREDICTED: amyloid beta A4 precursor protein-binding, family A, mem...
 0.0 [1..837] [1..837]
gi|2625025 - gi|2625025|gb|AAC05304.1| Mint1; neuronal munc18-1 binding protein [Homo sapiens]
 0.0 [1..837] [1..837]
APBA1_MOUSE - Amyloid beta A4 precursor protein-binding family A member 1 OS=Mus musculus GN=Apba1 PE=1 SV=2
 0.0 [1..837] [1..842]
APBA1_RAT - Amyloid beta A4 precursor protein-binding family A member 1 OS=Rattus norvegicus GN=Apba1 PE=1 SV=1
 0.0 [1..837] [1..839]
gi|76669037 - gi|76669037|ref|XP_593610.2| PREDICTED: similar to amyloid beta A4 precursor protein-binding, family...
 0.0 [1..837] [1..822]
gi|109111730 - gi|109111730|ref|XP_001093689.1| PREDICTED: similar to amyloid beta A4 precursor protein-binding, fa...
 0.0 [1..837] [1..841]

Back

Predicted Domain #1
Region A:
Residues: [1-171] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR HQRGRALEDL  60
   61 RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA RDGYDAERAQ DPEDESAYAV 120
  121 QYRPEAEEYT EQAEAEHAEA THRRALPNHL HFHSLEHEEA MNAAYSGYVY T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [172-254] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRLFHRGEDE PYSEPYADYG GLQEHVYEEI GDAPELDARD GLRLYEQERD EAAAYRQEAL  60
   61 GARLHHYDER SDGESDSPEK EAE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [255-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAPYPRMDSY EQEEDIDQIV AEVKQSMSSQ SLDKAAEDMP EAEQDLERPP TPAGGRPDSP  60
   61 GLQAPAGQQR AVGPAGGGEA GQRYSKEKRD AISLAIKDIK EAIEEVKTRT IRSPYTPDEP 120
  121 KEPIWVMRQD ISPTRDCDDQ RPMDGDSPSP GSSSPLGAES SSTSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [420-504] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPSDPVEAST NKESRKSLAS FPTYVEVPGP CDPEDLIDGI IFAANYLGST QLLSDKTPSK  60
   61 NVRMMQAQEA VSRIKMAQKL AKSRK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.96
Match: 1n3hA
Description: Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.30438399835377 bayes_pls_golite062009
protein binding 1.85780451223644 bayes_pls_golite062009
molecular transducer activity 1.33652392843319 bayes_pls_golite062009
signal transducer activity 1.33652392843319 bayes_pls_golite062009
transporter activity 1.29925758003665 bayes_pls_golite062009
clathrin binding 1.26358983594552 bayes_pls_golite062009
cell adhesion molecule binding 1.18949469885023 bayes_pls_golite062009
transcription regulator activity 1.07608551024196 bayes_pls_golite062009
nucleic acid binding 0.907985718286156 bayes_pls_golite062009
phospholipid binding 0.864843473490307 bayes_pls_golite062009
DNA binding 0.818468074940498 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
substrate-specific transporter activity 0.552872712432362 bayes_pls_golite062009
phosphoinositide binding 0.45899353522401 bayes_pls_golite062009
receptor binding 0.391425518916624 bayes_pls_golite062009
receptor activity 0.257794982570723 bayes_pls_golite062009
transmembrane receptor activity 0.102504792589299 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [505-757] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAPEGESQPM TEVDLFISTQ RIKVLNADTQ ETMMDHPLRT ISYIADIGNI VVLMARRRMP  60
   61 RSNSQENVEA SHPSQDGKRQ YKMICHVFES EDAQLIAQSI GQAFSVAYQE FLRANGINPE 120
  121 DLSQKEYSDL LNTQDMYNDD LIHFSKSENC KDVFIEKQKG EILGVVIVES GWGSILPTVI 180
  181 IANMMHGGPA EKSGKLNIGD QIMSINGTSL VGLPLSTCQS IIKGLKNQSR VKLNIVRCPP 240
  241 VTTVLIRRPD LRY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.221849
Match: 1te0A
Description: Structural analysis of DegS, a stress sensor of the bacterial periplasm
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.11987336027745 bayes_pls_golite062009
peptidase activity 2.03396925424902 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.75197091966116 bayes_pls_golite062009
endopeptidase activity 1.63841663816937 bayes_pls_golite062009
binding 1.4493073430417 bayes_pls_golite062009
PDZ domain binding 1.4161955255054 bayes_pls_golite062009
catalytic activity 1.40927913545237 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
nucleic acid binding 1.14575507779171 bayes_pls_golite062009
transcription regulator activity 1.10854960463642 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
DNA binding 0.959755415594752 bayes_pls_golite062009
amine transmembrane transporter activity 0.766679710300835 bayes_pls_golite062009
serine hydrolase activity 0.757825908093539 bayes_pls_golite062009
serine-type peptidase activity 0.743422247748155 bayes_pls_golite062009
signal transducer activity 0.702950445770193 bayes_pls_golite062009
molecular transducer activity 0.702950445770193 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
substrate-specific transporter activity 0.500408526353621 bayes_pls_golite062009
serine-type endopeptidase activity 0.486187854727418 bayes_pls_golite062009
ErbB-2 class receptor binding 0.449763185979101 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.304039235146353 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009
receptor activity 0.180964966947445 bayes_pls_golite062009
protein binding 0.153868222781357 bayes_pls_golite062009
cystic fibrosis transmembrane conductance regulator binding 0.114699700156051 bayes_pls_golite062009
syntaxin-6 binding 0.114699700156051 bayes_pls_golite062009
cytoskeletal protein binding 0.0187659836234897 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [758-837] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATPHEKIVHI LSNAVGEIHM  60
   61 KTMPAAMYRL LTAQEQPVYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.39794
Match: 1u3bA
Description: Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.40143803981618 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
PDZ domain binding 1.4161955255054 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
transcription regulator activity 1.10854960463642 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
signal transducer activity 0.877891218909175 bayes_pls_golite062009
molecular transducer activity 0.877891218909175 bayes_pls_golite062009
amine transmembrane transporter activity 0.766679710300835 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
substrate-specific transporter activity 0.500408526353621 bayes_pls_golite062009
ErbB-2 class receptor binding 0.449763185979101 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.304039235146353 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009
cystic fibrosis transmembrane conductance regulator binding 0.114699700156051 bayes_pls_golite062009
syntaxin-6 binding 0.114699700156051 bayes_pls_golite062009
cytoskeletal protein binding 0.0187659836234897 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle