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View Structure Prediction Details

Protein: gi|39777606, gi|...
Organism: Homo sapiens
Length: 927 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|39777606, gi|....

Description E-value Query
Range
Subject
Range
gi|1654344 - gi|1654344|gb|AAB17896.1| guanine nucleotide exchange factor p115-RhoGEF [Homo sapiens]
796.0 [0..16] [927..1]
ARHG1_MOUSE - Rho guanine nucleotide exchange factor 1 OS=Mus musculus GN=Arhgef1 PE=1 SV=2
758.0 [0..22] [922..6]
gi|62751753, gi|... - gi|62751753|ref|NP_067726.3| Rho guanine nucleotide exchange factor (GEF) 1 [Rattus norvegicus], gi|...
726.0 [0..22] [922..6]

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Predicted Domain #1
Region A:
Residues: [1-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLSTWSSP AEPREMEDFA RGAASPGPSR PGLVPVSIIG AEDEDFENEL ETNSEEQNSQ  60
   61 FQSLEQVKRR PAHLMALLQH VALQFEPGPL LCCLHADMLG SLGPKEAKKA FLDFYHSFLE 120
  121 KTAVLRVPVP PNVAFELDRT RADLISEDVQ RRFVQEVVQS QQVAVGRQLE DFRSKRLMGM 180
  181 TPWEQELAQL EAWVGRDRAS YEARERHVAE RLLMHLEEMQ HTISTDEEKS AAVVNAIGLY 240
  241 MRHLGVRTKS GDKKSGRNFF RKKVM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.0
Match: 1shzC
Description: Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [266-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD RKGGVGMPSR  60
   61 DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS PQGPMSLESL APPESTDEGA 120
  121 ETESPEPGDE GEPGRSGLEL EPEEPPGWRE LVP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.5
Match: 1wckA
Description: Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [419-786]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDTLHSLPKS QVKRQEVISE LLVTEAAHVR MLRVLHDLFF QPMAECLFFP LEELQNIFPS  60
   61 LDELIEVHSL FLDRLMKRRQ ESGYLIEEIG DVLLARFDGA EGSWFQKISS RFCSRQSFAL 120
  121 EQLKAKQRKD PRFCAFVQEA ESRPRCRRLQ LKDMIPTEMQ RLTKYPLLLQ SIGQNTEEPT 180
  181 EREKVELAAE CCREILHHVN QAVRDMEDLL RLKDYQRRLD LSHLRQSSDP MLSEFKNLDI 240
  241 TKKKLVHEGP LTWRVTKDKA VEVHVLLLDD LLLLLQRQDE RLLLKSHSRT LTPTPDGKTM 300
  301 LRPVLRLTSA MTREVATDHK AFYVLFTWDQ EAQIYELVAQ TVSERKNWCA LITETAGSLK 360
  361 VPAPASRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.69897
Match: 1txdA
Description: Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [787-927]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPRPSPSSTR EPLLSSSENG NGGRETSPAD ARTERILSDL LPFCRPGPEG QLAATALRKV  60
   61 LSLKQLLFPA EEDNGAGPPR DGDGVPGGGP LSPARTQEIQ ENLLSLEETM KQLEELEEEF 120
  121 CRLRPLLSQL GGNSVPQPGC T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle