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View Structure Prediction Details

Protein: gi|22035612
Organism: Homo sapiens
Length: 938 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|22035612.

Description E-value Query
Range
Subject
Range
gi|21752857 - gi|21752857|dbj|BAC04248.1| unnamed protein product [Homo sapiens]
0.0 [1..938] [1..938]
OSBL6_MOUSE - Oxysterol-binding protein-related protein 6 OS=Mus musculus GN=Osbpl6 PE=1 SV=1
0.0 [13..938] [34..959]
gi|76609395 - gi|76609395|ref|XP_872029.1| PREDICTED: similar to oxysterol-binding protein-like protein 6 isoform ...
0.0 [9..938] [30..959]
gi|114581946 - gi|114581946|ref|XP_515939.2| PREDICTED: oxysterol-binding protein-like protein 6 isoform 9 [Pan tro...
0.0 [13..938] [34..953]
gi|109468331, gi... - gi|109470088|ref|XP_001062227.1| PREDICTED: similar to Oxysterol-binding protein-related protein 6 (...
0.0 [1..938] [23..928]

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Predicted Domain #1
Region A:
Residues: [1-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHQLSLIRGN RGRSIHILER TASSSTEPSV SRQLLEPEPV PLSKEADSWE IIEGLKIGQT  60
   61 NVQKPDKHEG FMLKKRKWPL KGWHKRFFVL DNGMLKYSKA PLDIQKGKVH GSIDVGLSVM 120
  121 SIKKKARRID LDTEEHIYHL KVKSQDWFDA WVSKLRHHRL YRQNEIVRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 2q13A
Description: No description for 2q13A was found.

Predicted Domain #2
Region A:
Residues: [170-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRDASFHIFP STSTAESSPA ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT CTTGQSKVAA  60
   61 WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [271-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNFTDMQANC VDISKKDKRV TRRWRTKSVS KDTKIQLQEG PPAKGQFSTT RRRQRLAAAV  60
   61 ATTVPFSATM SPVRLHSSNP NLCADIEFQT PPSHLTDPLE SSTDYTKLQE EFCLIAQKVH 120
  121 SLLKSAFNSI AIEKEKLKQM VSEQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [416-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSKGHSTQMA RLRQSLSQAL NQNAELRSRL NRIHSESIIC DQVVSVNIIP SPDEAGEQIH  60
   61 VSLPLSQQVA NESRLSMSES VSEFFDAQEV LLSASSSENE ASDDESYISD VSDNISEDNT 120
  121 SVADNISRQI LNGELTGGAF RNGRRACLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [565-938]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APCPDTSNIN LWNILRNNIG KDLSKVSMPV ELNEPLNTLQ HLCEEMEYSE LLDKASETDD  60
   61 PYERMVLVAA FAVSGYCSTY FRAGSKPFNP VLGETYECIR EDKGFRFFSE QVSHHPPISA 120
  121 CHCESKNFVF WQDIRWKNKF WGKSMEILPV GTLNVMLPKY GDYYVWNKVT TCIHNILSGR 180
  181 RWIEHYGEVT IRNTKSSVCI CKLTFVKVNY WNSNMNEVQG VVIDQEGKAV YRLFGKWHEG 240
  241 LYCGVAPSAK CIWRPGSMPT NYELYYGFTR FAIELNELDP VLKDLLPPTD ARFRPDQRFL 300
  301 EEGNLEAAAS EKQRVEELQR SRRRYMEENN LEHIPKFFKK VIDANQREAW VSNDTYWELR 360
  361 KDPGFSKVDS PVLW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.0
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
oxysterol binding 2.56824234952236 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 1.67154210149282 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
0.35288515581255 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle