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Protein Overview: gi|16129083|ref|...

General Information:
Name(s) found: gi|16129083|ref|NP_415638.1| [nr-271106-contam.fasta]
gi|1787364|gb|AAC74204.1| [nr-271106-contam.fasta]
gi|16129083|ref|NP_415638.1|: [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
Description(s) found:
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  • NAD-dependent deacetylase [Escherichia coli K12] [nr-271106-contam.fasta]
  • deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli K12] [nr-271106-contam.fasta]
  • deacetylase of acetyl-CoA synthetase [Escherichia coli str. K-12 substr. MG1655] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 279 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: protein amino acid deacetylation [IEA]
    chromatin silencing [IEA]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPILink to PubMed article]
    metal ion binding [IEA]
    NAD binding [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRRGHRLS RFRKNKRRLR ERLRQRIFFR DKVVPEAMEK PRVLVLTGAG ISAESGIRTF  60
   61 RAADGLWEEH RVEDVATPEG FDRDPELVQA FYNARRRQLQ QPEIQPNAAH LALAKLQDAL 120
  121 GDRFLLVTQN IDNLHERAGN TNVIHMHGEL LKVRCSQSGQ VLDWTGDVTP EDKCHCCQFP 180
  181 APLRPHVVWF GEMPLGMDEI YMALSMADIF IAIGTSGHVY PAAGFVHEAK LHGAHTVELN 240
  241 LEPSQVGNEF AEKYYGPASQ VVPEFVEKLL KGLKAGSIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] PSI-BLAST 71.0 Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.31731368009317 bayes_pls_golite062009
  • DNA binding
    		•  1.84059392605809 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.83565083706175 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.83565083706175 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83132687449755 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.74695290583345 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.73884380618194 bayes_pls_golite062009
  • binding
    		•  1.63619372613603 bayes_pls_golite062009
  • transporter activity
    		•  1.02987325768951 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.879539673228343 bayes_pls_golite062009
  • deacetylase activity
    		•  0.850785854706901 bayes_pls_golite062009
  • transcription factor activity
    		•  0.758967814548108 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription factor binding
    		•  0.64778523540991 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.62029498163975 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.56000396203236 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.52020182886741 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.47231237137431 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.128843577740998 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.116839617002046 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0875567934348688 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.05634462944063 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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