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Protein Overview: EG11873

General Information:
Name(s) found: fieF / EG11873 [EcoGene]
Description(s) found:
Found 7 descriptions.
SHOW ALL
  • ferrous iron and zinc transporter / Ferrous-iron and zinc efflux pump; cation diffusion facilitator family; dimeric [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [IEA]
    plasma membrane [IEA]
    Biological Process: cellular iron ion homeostasis [IGILink to PubMed article]
    transmembrane transport [IEA]
    ferrous iron transport [IDALink to PubMed article]
    zinc ion transport [IDALink to PubMed article]
    cadmium ion transport [IDALink to PubMed article]
    cellular zinc ion homeostasis [IDALink to PubMed article]
    cellular cadmium ion homeostasis [IDALink to PubMed article]
    Molecular Function: iron ion binding [IEA]
    zinc efflux active transmembrane transporter activity [IDALink to PubMed article]
    cadmium ion transmembrane transporter activity [IDALink to PubMed article]
    ferrous iron transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQSYGRLVS RAAIAATAMA SLLLLIKIFA WWYTGSVSIL AALVDSLVDI GASLTNLLVV  60
   61 RYSLQPADDN HSFGHGKAES LAALAQSMFI SGSALFLFLT GIQHLISPTP MTDPGVGVIV 120
  121 TIVALICTII LVSFQRWVVR RTQSQAVRAD MLHYQSDVMM NGAILLALGL SWYGWHRADA 180
  181 LFALGIGIYI LYSALRMGYE AVQSLLDRAL PDEERQEIID IVTSWPGVSG AHDLRTRQSG 240
  241 PTRFIQIHLE MEDSLPLVQA HMVADQVEQA ILRRFPGSDV IIHQDPCSVV PREGKRSMLS 300
  301

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..300] PSI-BLAST 62.69897 No description for 2qfiA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cation transmembrane transporter activity
    		•  4.80415740186568 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.7111088918389 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.31582321262476 bayes_pls_golite062009
  • cadmium ion transmembrane transporter activity
    		•  3.70168909103546 bayes_pls_golite062009
  • cation efflux transmembrane transporter activity
    		•  3.58605967664273 bayes_pls_golite062009
  • zinc efflux transmembrane transporter activity
    		•  3.58605967664273 bayes_pls_golite062009
  • zinc efflux active transmembrane transporter activity
    		•  3.58605967664273 bayes_pls_golite062009
  • ferrous iron transmembrane transporter activity
    		•  3.11977033026307 bayes_pls_golite062009
  • zinc ion transmembrane transporter activity
    		•  2.95515682622113 bayes_pls_golite062009
  • transporter activity
    		•  2.75060749825863 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.61478776136804 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.49211952065411 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.29284396884348 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  1.28901626534199 bayes_pls_golite062009
  • efflux transmembrane transporter activity
    		•  1.25549862417229 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.01332825422669 bayes_pls_golite062009
  • binding
    		•  0.80253540865533 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.4725448545847 bayes_pls_golite062009
  • cation channel activity
    		•  0.114605430567645 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.0866732167896778 bayes_pls_golite062009
  • protein binding
    		•  0.0557829197821959 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle