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Protein Overview: EG10523

General Information:
Name(s) found: rsmA / EG10523 [EcoGene]
Description(s) found:
Found 6 descriptions.
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  • 16S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent / 16S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent; mutant is kasugamycin resistant; multicopy suppressor of era(Cs) [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 273 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: rRNA base methylation [IMPLink to PubMed article]
    response to antibiotic [IEA]
    ribosomal small subunit assembly [IMPLink to PubMed article]
    rRNA processing [IMPLink to PubMed article]
    Molecular Function: double-stranded DNA binding [IDALink to PubMed article]
    mRNA binding [IDALink to PubMed article]
    rRNA binding [IDALink to PubMed article]
    rRNA (adenine-N6,N6-)-dimethyltransferase activity [IDALink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNRVHQGHL ARKRFGQNFL NDQFVIDSIV SAINPQKGQA MVEIGPGLAA LTEPVGERLD  60
   61 QLTVIELDRD LAARLQTHPF LGPKLTIYQQ DAMTFNFGEL AEKMGQPLRV FGNLPYNIST 120
  121 PLMFHLFSYT DAIADMHFML QKEVVNRLVA GPNSKAYGRL SVMAQYYCNV IPVLEVPPSA 180
  181 FTPPPKVDSA VVRLVPHATM PHPVKDVRVL SRITTEAFNQ RRKTIRNSLG NLFSVEVLTG 240
  241 MGIDPAMRAE NISVAQYCQM ANYLAENAPL QES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] PSI-BLAST 59.0 2.1 Angstrom Crystal structure of KsgA: A Universally Conserved Adenosine Dimethyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.67177992319602 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.5512266163483 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.49492581548369 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.14498896320526 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.06652984530965 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.06652984530965 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  1.63076727020333 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.42049721553167 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.26493190370687 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.12859857407629 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.10713374933008 bayes_pls_golite062009
  • DNA binding
    		•  1.03011331296251 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.731396842794323 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  0.720411427168235 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.606920378432989 bayes_pls_golite062009
  • binding
    		•  0.546744797014504 bayes_pls_golite062009
  • mitochondrial transcription initiation factor activity
    		•  0.481383105532041 bayes_pls_golite062009
  • rRNA (guanine-N2-)-methyltransferase activity
    		•  0.427131446117391 bayes_pls_golite062009
  • rRNA (cytosine) methyltransferase activity
    		•  0.346042596102079 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  0.299393192819978 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  0.299393192819978 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  0.234572322347698 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.188049877065151 bayes_pls_golite062009
  • transcription factor binding
    		•  0.149382105526243 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.130647573658872 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle