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Protein Overview: EG10123

General Information:
Name(s) found: birA / EG10123 [EcoGene]
Description(s) found:
Found 6 descriptions.
SHOW ALL
  • bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/ DNA-binding transcriptional repressor, bio-5'-AMP-binding / Bifunctional biotin protein ligase, biotin operon repressor; biotin-[acetyl-CoA carboxylase] holoenzyme synthase; monomeric [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 321 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: transcription [IEA]
    protein modification process [IEA]
    regulation of transcription, DNA-dependent [IEA]
    biotin biosynthetic process [IMPLink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    DNA binding [IDALink to PubMed article][IEA]
    protein binding [IPILink to PubMed article]
    catalytic activity [IEA]
    biotin-[acetyl-CoA-carboxylase] ligase activity [IDALink to PubMed article][IEA]
    transcription repressor activity [IEA][IEPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDNTVPLKL IALLANGEFH SGEQLGETLG MSRAAINKHI QTLRDWGVDV FTVPGKGYSL  60
   61 PEPIQLLNAK QILGQLDGGS VAVLPVIDST NQYLLDRIGE LKSGDACIAE YQQAGRGRRG 120
  121 RKWFSPFGAN LYLSMFWRLE QGPAAAIGLS LVIGIVMAEV LRKLGADKVR VKWPNDLYLQ 180
  181 DRKLAGILVE LTGKTGDAAQ IVIGAGINMA MRRVEESVVN QGWITLQEAG INLDRNTLAA 240
  241 MLIRELRAAL ELFEQEGLAP YLSRWEKLDN FINRPVKLII GDKEIFGISR GIDKQGALLL 300
  301 EQDGIIKPWM GGEISLRSAE K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..321] PSI-BLAST 80.221849 THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-oxygen bonds
    		•  3.33073922220594 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  3.33073922220594 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  3.33034630936933 bayes_pls_golite062009
  • ligase activity
    		•  3.05852492533937 bayes_pls_golite062009
  • catalytic activity
    		•  2.36416267096403 bayes_pls_golite062009
  • biotin-[acetyl-CoA-carboxylase] ligase activity
    		•  1.84290209862678 bayes_pls_golite062009
  • biotin-protein ligase activity
    		•  1.84290209862678 bayes_pls_golite062009
  • transcription activator activity
    		•  0.53294679084865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.53285802828572 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.514652697234715 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.268902262140417 bayes_pls_golite062009
  • binding
    		•  0.204413263196103 bayes_pls_golite062009
  • DNA binding
    		•  0.114801541522161 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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