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Protein Overview: EG10243

General Information:
Name(s) found: dnaQ / EG10243 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • DNA polymerase III epsilon subunit / DNA polymerase III epsilon subunit; streptomycin, azaserine resistant; 3' to 5' proofreading, lexA regulon [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 243 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: DNA replication [IEA]
    Molecular Function: nucleic acid binding [IEA]
    magnesium ion binding [IEA]
    DNA binding [IEA]
    nucleotidyltransferase activity [IEA]
    DNA-directed DNA polymerase activity [IEA]
    protein binding [IPILink to PubMed article]
    metal ion binding [IEA]
    exonuclease activity [IEA]
    nuclease activity [IEA]
    manganese ion binding [IEA]
    transferase activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAITRQIV LDTETTGMNQ IGAHYEGHKI IEIGAVEVVN RRLTGNNFHV YLKPDRLVDP  60
   61 EAFGVHGIAD EFLLDKPTFA EVADEFMDYI RGAELVIHNA AFDIGFMDYE FSLLKRDIPK 120
  121 TNTFCKVTDS LAVARKMFPG KRNSLDALCA RYEIDNSKRT LHGALLDAQI LAEVYLAMTG 180
  181 GQTSMAFAME GETQQQQGEA TIQRIVRQAS KLRVVFATDE EIAAHEARLD LVQKKGGSCL 240
  241 WRA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] PSI-BLAST 51.0 N-terminal exonuclease domain of the epsilon subunit of DNA polymerase III

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA polymerase activity
    		•  7.87431862983329 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  7.78411937387917 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  5.3880945520411 bayes_pls_golite062009
  • exonuclease activity
    		•  2.86892175148145 bayes_pls_golite062009
  • nuclease activity
    		•  2.84202779131927 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87430802282815 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.75713164321634 bayes_pls_golite062009
  • transferase activity
    		•  1.47288345517763 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.41871623152578 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • endonuclease activity
    		•  0.935348031740788 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.64268174969672 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.26279899872348 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.251640316483416 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.18445559832317 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.1355017328177 bayes_pls_golite062009
  • binding
    		•  0.122249780594036 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle