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Protein Overview: EG10797

General Information:
Name(s) found: purL / EG10797 [EcoGene]
Description(s) found:
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  • phosphoribosylformyl-glycineamide synthetase / Phosphoribosylformylglycinamide synthase; contains a synthase domain (N) and a glutamine amidotransferase domain (C) [EcoGene]
  • phosphoribosylformylglycineamide synthetase [nr-271106-contam.fasta]
  • phosphoribosylformyl-glycineamide synthetase [Escherichia coli K12] [nr-271106-contam.fasta]
  • phosphoribosylformylglycinamidine synthase [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • phosphoribosylformyl-glycineamide synthetase [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 1295 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][IEA]
    Biological Process: purine nucleotide biosynthetic process [IEA]
    glutamine metabolic process [IEA]
    'de novo' IMP biosynthetic process [IEA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    catalytic activity [IEA]
    ligase activity [IEA]
    phosphoribosylformylglycinamidine synthase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMEILRGSPA LSAFRINKLL ARFQAARLPV HNIYAEYVHF ADLNAPLNDD EHAQLERLLK  60
   61 YGPALASHAP QGKLLLVTPR PGTISPWSSK ATDIAHNCGL QQVNRLERGV AYYIEAGTLT 120
  121 NEQWQQVTAE LHDRMMETVF FALDDAEQLF AHHQPTPVTS VDLLGQGRQA LIDANLRLGL 180
  181 ALAEDEIDYL QDAFTKLGRN PNDIELYMFA QANSEHCRHK IFNADWVIDG EQQPKSLFKM 240
  241 IKNTFETTPD HVLSAYKDNA AVMEGSEVGR YFADHETGRY DFHQEPAHIL MKVETHNHPT 300
  301 AISPWPGAAT GSGGEIRDEG ATGRGAKPKA GLVGFSVSNL RIPGFEQPWE EDFGKPERIV 360
  361 TALDIMTEGP LGGAAFNNEF GRPALNGYFR TYEEKVNSHN GEELRGYHKP IMLAGGIGNI 420
  421 RADHVQKGEI NVGAKLVVLG GPAMNIGLGG GAASSMASGQ SDADLDFASV QRDNPEMERR 480
  481 CQEVIDRCWQ LGDANPILFI HDVGAGGLSN AMPELVSDGG RGGKFELREI LSDEPGMSPL 540
  541 EIWCNESQER YVLAVAADQL PLFDELCKRE RAPYAVIGEA TEELHLSLHD RHFDNQPIDL 600
  601 PLDVLLGKTP KMTRDVQTLK AKGDALAREG ITIADAVKRV LHLPTVAEKT FLVTIGDRSV 660
  661 TGMVARDQMV GPWQVPVANC AVTTASLDSY YGEAMAIGER APVALLDFAA SARLAVGEAL 720
  721 TNIAATQIGD IKRIKLSANW MAAAGHPGED AGLYEAVKAV GEELCPALGL TIPVGKDSMS 780
  781 MKTRWQEGNE EREMTSPLSL VISAFARVED VRHTITPQLS TEDNALLLID LGKGNNALGA 840
  841 TALAQVYRQL GDKPADVRDV AQLKGFYDAI QALVAQRKLL AYHDRSDGGL LVTLAEMAFA 900
  901 GHCGIDADIA TLGDDRLAAL FNEELGAVIQ VRAADREAVE SVLAQHGLAD CVHYVGQAVS 960
  961 GDRFVITANG QTVFSESRTT LRVWWAETTW QMQRLRDNPE CADQEHQAKS NDADPGLNVK1020
 1021 LSFDINEDVA APYIATGARP KVAVLREQGV NSHVEMAAAF HRAGFDAIDV HMSDLLTGRT1080
 1081 GLEDFHALVA CGGFSYGDVL GAGEGWAKSI LFNDRVRDEF ATFFHRPQTL ALGVCNGCQM1140
 1141 MSNLRELIPG SELWPRFVRN TSDRFEARFS LVEVTQSPSL LLQGMVGSQM PIAVSHGEGR1200
 1201 VEVRDAAHLA ALESKGLVAL RYVDNFGKVT ETYPANPNGS PNGITAVTTE SGRVTIMMPH1260
 1261 PERVFRTVSN SWHPENWGED GPWMRIFRNA RKQLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1295] PSI-BLAST 1000.0 Structure of Formylglycinamide synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoribosylformylglycinamidine cyclo-ligase activity
    		•  3.04322905277855 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.97429034492683 bayes_pls_golite062009
  • catalytic activity
    		•  2.42746873085914 bayes_pls_golite062009
  • cyclo-ligase activity
    		•  2.40623349460413 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  2.05243869055537 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.74828881793189 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.74029540439985 bayes_pls_golite062009
  • ligase activity
    		•  1.57503501977169 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.2570804600775 bayes_pls_golite062009
  • binding
    		•  1.25028632595227 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.78656048097577 bayes_pls_golite062009
  • protein binding
    		•  0.277844441308003 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.12569720972861 bayes_pls_golite062009
  • kinase activity
    		•  0.118160290398407 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle