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Protein Overview: EG10458

General Information:
Name(s) found: hsdM / EG10458 [EcoGene]
Description(s) found:
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  • DNA methyltransferase M / DNA methyltransferase M, host modification of foreign DNA [EcoGene]
  • CG Site No. 621; alternate gene names hs, hsm, hsp, rm [Escherichia coli] [nr-271106-contam.fasta]
  • DNA methylase M [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • DNA methylase M [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
  • DNA methyltransferase M [Escherichia coli str. K-12 substr. MG1655] [c_elegans-WS236-ecoli-05Mar2013-contam.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 529 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA methylation [IEA]
    DNA restriction-modification system [IEA]
    methylation [IEA]
    Molecular Function: nucleic acid binding [IEA]
    DNA binding [IEA]
    N-methyltransferase activity [IEA]
    protein binding [IPILink to PubMed article]
    methyltransferase activity [IEA]
    transferase activity [IEA]
    site-specific DNA-methyltransferase (adenine-specific) activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNDLVAKL WKLCDNLRDG GVSYQNYVNE LASLLFLKMC KETGQEAEYL PEGYRWDDLK  60
   61 SRIGQEQLQF YRKMLVHLGE DDKKLVQAVF HNVSTTITEP KQITALVSNM DSLDWYNGAH 120
  121 GKSRDDFGDM YEGLLQKNAN ETKSGAGQYF TPRPLIKTII HLLKPQPREV VQDPAAGTAG 180
  181 FLIEADRYVK SQTNDLDDLD GDTQDFQIHR AFIGLELVPG TRRLALMNCL LHDIEGNLDH 240
  241 GGAIRLGNTL GSDGENLPKA HIVATNPPFG SAAGTNITRT FVHPTSNKQL CFMQHIIETL 300
  301 HPGGRAAVVV PDNVLFEGGK GTDIRRDLMD KCHLHTILRL PTGIFYAQGV KTNVLFFTKG 360
  361 TVANPNQDKN CTDDVWVYDL RTNMPSFGKR TPFTDEHLQP FERVYGEDPH GLSPRTEGEW 420
  421 SFNAEETEVA DSEENKNTDQ HLATSRWRKF SREWIRTAKS DSLDISWLKD KDSIDADSLP 480
  481 EPDVLAAEAM GELVQALSEL DALMRELGAS DEADLQRQLL EEAFGGVKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..529] PSI-BLAST 110.0 Crystal structure of Type I restriction enzyme EcoKI M protein (EC 2.1.1.72) (M.EcoKI)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-methyltransferase activity
    		•  7.61853880993981 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  7.11249059771057 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.39676833658685 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.33061049943022 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.22830304942698 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.89831891552024 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.89831891552024 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  1.30685781453463 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.00318794562816 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  0.950437293690352 bayes_pls_golite062009
  • DNA (cytosine-5-)-methyltransferase activity
    		•  0.937171599492037 bayes_pls_golite062009
  • binding
    		•  0.907448038004683 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.517021612434243 bayes_pls_golite062009
  • DNA binding
    		•  0.508133107367239 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.443691572120283 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  0.421039991390153 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.40782425952463 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle