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Protein Overview: EG10462

General Information:
Name(s) found: htpX / EG10462 [EcoGene]
Description(s) found:
Found 6 descriptions.
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  • putative endopeptidase / Zinc metalloprotease HtpX, membrane-bound; cleaves SecY in vivo and in vitro; self-cleaves; M48 family [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 293 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [IEA]
    plasma membrane [IEA]
    Biological Process: proteolysis [IEA]
    response to stress [IEA]
    Molecular Function: zinc ion binding [IEA]
    metal ion binding [IEA]
    metalloendopeptidase activity [IDALink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR  60
   61 SVGGEVIEQP RNERERWLVN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV 120
  121 STGLLQNMSP DEAEAVIAHE ISHIANGDMV TMTLIQGVVN TFVIFISRIL AQLAAGFMGG 180
  181 NRDEGEESNG NPLIYFAVAT VLELVFGILA SIITMWFSRH REFHADAGSA KLVGREKMIA 240
  241 ALQRLKTSYE PQEATSMMAL CINGKSKSLS ELFMTHPPLD KRIEALRTGE YLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] Pfam 19.744727 No description for PF06509.2 was found. No confident structure predictions are available.
    2 View Details [70..152] FFAS03 1.04 Zinc protease
    3 View Details [153..293] Pfam 3.508638 No description for PF01435.9 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.52170890235712 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.20265930105587 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.46762211541241 bayes_pls_golite062009
  • hydrolase activity
    		•  2.3590043825345 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.3107572739426 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.69802747425985 bayes_pls_golite062009
  • catalytic activity
    		•  0.843772148375291 bayes_pls_golite062009
  • binding
    		•  0.655247478888488 bayes_pls_golite062009
  • protein binding
    		•  0.273409914175328 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.160545038651425 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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