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Protein Overview: CYSG_SALTI

General Information:
Name(s) found: CYSG_SALTI [Swiss-Prot]
Description(s) found:
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  • gi|25514775|pir||AD1001 siroheme synthase (EC 4.99.1.-) [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain CT18) [NCBI NR]
  • gi|16505114|emb|CAD08136.1| siroheme synthase [Salmonella enterica subsp. enterica serovar Typhi] [NCBI NR]
  • Siroheme synthase OS=Salmonella typhi GN=cysG PE=3 SV=1 [Swiss-Prot]
  • siroheme synthase [Salmonella enterica subsp. enterica serovar Typhi Ty2]gi|16762808|ref|NP_458425.1| siroheme synthase [Salmonella enterica subsp. enterica serovar Typhi str. CT18]gi|29139932|gb|AAO71497.1| siroheme synthase [Salmonella enterica subsp. [nrdb_11152004_Chlamydomonas]
  • siroheme synthase [Salmonella enterica subsp. enterica serovar Typhi] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • siroheme synthase (EC 4.99.1.-) [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain CT18) [nr-271106-contam.fasta]
    • Organism: Salmonella enterica subsp. enterica serovar Typhi
    Length: 457 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHLPIFCQL RDRDCLIVGG GDVAERKARL LLEAGARLTV NALTFIPQFT VWVNEGMLTL  60
   61 VEGPFDETLL DSCWLAIAAT DDDTVNQRVS EAAESRRIFC NVVDAPKAAS FIMPSIIDRS 120
  121 PLMVAVSSGG TSPVLARLLR EKLESLLPQH LGQVARYAGQ LRARVKKQFA TMGERRRFWE 180
  181 KFFVNDRLAQ SLANADEKAV NATTEHLFSE PLDHRGEVVL VGAGPGDAGL LTLKGLQQIQ 240
  241 QADIVVYDRL VSDDIMNLVR RDADRVFVGK RAGYHCVPQE EINQILLREA QKGKRVVRLK 300
  301 GGDPFIFGRG GEELETLCHA GIPFSVVPGI TAASGCSAYS GIPLTHRDYA QSVRLVTGHL 360
  361 KTGGELDWEN LAAEKQTLVF YMGLNQAATI QEKLIAFGME ANMPVALVEN GTSVKQRVVH 420
  421 GVLTQLGELA QQVESPALII VGRVVALRDK LNWFSNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..457] PSI-BLAST 135.0 Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uroporphyrin-III C-methyltransferase activity
    		•  3.573271502205 bayes_pls_golite062009
  • C-methyltransferase activity
    		•  3.35393353163232 bayes_pls_golite062009
  • precorrin-4 C11-methyltransferase activity
    		•  2.18371138649366 bayes_pls_golite062009
  • catalytic activity
    		•  1.48349578618275 bayes_pls_golite062009
  • transferase activity
    		•  0.912524944496351 bayes_pls_golite062009
  • binding
    		•  0.591538530271277 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.463693177369635 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.454156823400351 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.323461631906645 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • protein binding
    		•  0.0615599502226839 bayes_pls_golite062009
  • uroporphyrinogen-III synthase activity
    		•  0.00871858903098705 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle