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Protein Overview: SMC2

General Information:
Name(s) found: SMC2 [HGNC (HUGO)]
Description(s) found:
Found 31 descriptions.
SHOW ALL
  • structural maintenance of chromosomes 2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1197 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS  60
   61 NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 120
  121 NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 180
  181 AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 240
  241 LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 300
  301 DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 360
  361 ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 420
  421 MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 480
  481 KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 540
  541 LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 600
  601 DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 660
  661 GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 720
  721 MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 780
  781 KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 840
  841 EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 900
  901 EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN 960
  961 NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE1020
 1021 DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE1080
 1081 NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF1140
 1141 IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 40.522879 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
    2 View Details [174..481] FFAS03 2.27 No description for 2i1jA was found.
    3 View Details [482..697] FFAS03 4.54 Smc hinge domain
    4 View Details [698..1026] FFAS03 2.04 No description for 2oevA was found.
    5 View Details [1027..1197] PSI-BLAST 18.221849 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.69872504333327 bayes_pls_golite062009
  • binding
    		•  3.21663307302451 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.58390156971125 bayes_pls_golite062009
  • transporter activity
    		•  2.17383908004663 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.02444700826552 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • DNA binding
    		•  1.72568209621547 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.63193306273479 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35268825531078 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.654899784430321 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.608058786636536 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567932466447757 bayes_pls_golite062009
  • kinetochore binding
    		•  0.534490088080411 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.29158988711192 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • helicase activity
    		•  0.17080683362659 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • dynein binding
    		•  0.150959629961177 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • recombinase activity
    		•  0.0490751527151101 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.48985538444161 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85809295645854 bayes_pls_golite062009
  • DNA binding
    		•  1.71700314893388 bayes_pls_golite062009
  • protein binding
    		•  0.927138723776922 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.558475595998159 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.299763949828861 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.284996962785104 bayes_pls_golite062009
  • catalytic activity
    		•  0.265320175609019 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.248383422632029 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.235472660839816 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.233111707634177 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.154578921841996 bayes_pls_golite062009
  • ATPase activity
    		•  0.08869715759545 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0245162068641336 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle