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Protein Overview: AKT1

General Information:
Name(s) found: AKT1 [HGNC (HUGO)]
Description(s) found:
Found 32 descriptions.
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  • v-akt murine thymoma viral oncogene homolog 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 480 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC  60
   61 QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF 120
  121 RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180
  181 LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240
  241 RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300
  301 KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360
  361 ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK 420
  421 LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA 480
  481

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 13.0 No description for 2uvmA was found.
    2 View Details [145..397] PSI-BLAST 65.0 Structure of PDK1-S241A mutant kinase domain
    3 View Details [398..480] FFAS03 3.32 Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.72754591832642 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  3.3707139031954 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.87341016128079 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.84482185829578 bayes_pls_golite062009
  • profilin binding
    		•  2.77241328262501 bayes_pls_golite062009
  • actin filament binding
    		•  2.03444575838575 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.8384977631304 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.70142823077711 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  1.56969272757764 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53043443218632 bayes_pls_golite062009
  • kinase activity
    		•  1.49733072352288 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45333553095537 bayes_pls_golite062009
  • DNA binding
    		•  1.44750105267972 bayes_pls_golite062009
  • SH2 domain binding
    		•  1.41526564231882 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36365892826676 bayes_pls_golite062009
  • protein kinase activity
    		•  1.34246406302496 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • phosphatidylinositol-3,4-bisphosphate binding
    		•  1.15025513961661 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • transferase activity
    		•  1.05502123133116 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.00400540041137 bayes_pls_golite062009
  • kinase binding
    		•  0.961706066143 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • protein kinase binding
    		•  0.67284191028382 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.611829373978789 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase docking protein activity
    		•  0.47238283185104 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.470521479239198 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.391864697086635 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • hydrolase activity
    		•  0.354215977182915 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.34714857141225 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • structural molecule activity
    		•  0.320527491838187 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.12466518799375 bayes_pls_golite062009
  • alpha-catenin binding
    		•  0.102004310679969 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle