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Protein Overview: MED12_DANRE

General Information:
Name(s) found: MED12_DANRE [Swiss-Prot]
Description(s) found:
Found 8 descriptions.
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  • Mediator of RNA polymerase II transcription subunit 12 OS=Danio rerio GN=med12 PE=2 SV=1 [Swiss-Prot]
    • Organism: Danio rerio
    Length: 2173 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    mediator complex [IEA]
    Biological Process: transcription [IEA]
    neural crest cell development [IMP]
    multicellular organismal development [IEA]
    neuron differentiation [IMP]
    endoderm development [IGI][IMP]
    embryonic neurocranium morphogenesis [IMP]
    positive regulation of transcription [IGI]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [IEA]
    embryonic viscerocranium morphogenesis [IMP]
    midbrain development [IMP]
    forebrain development [IMP]
    kidney development [IMP]
    embryonic pectoral fin morphogenesis [IMP]
    iridophore differentiation [IMP]
    Molecular Function: transcription factor activity [IGI]
    RNA polymerase II transcription mediator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAFGVLSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK  60
   61 NVNFNSSKIS SNFSSIIAEK LRCNTFPDTG KRKPQVNQKD NFWLVTARSQ SSINNWFTDL 120
  121 AGTKPLTQLA KKVPIFSKKE EVFGYLAKYS VPVMRSAWMI KMTCAYHAAI TENKMKKRHV 180
  181 IDPCIEWTPI ITKYLWEQLQ KVAEFYRQSP SQGCGSPLPA PPAEVETAMK QWEYNEKLAM 240
  241 FMFQDGMLDR HEFLTWVLEC FEKIRPGEDE LLRLLLPLLL QYSGEFVQSA YLSRRLAYFC 300
  301 TRRLNLLLSD GSIGPGPGGH QAHGISAQQG NALPPTPTSQ PAGGNQPQTP FTDFYICPQH 360
  361 RPVVFGLSCM LQSIVLCCPS ALVWHYSLTD SRNKTGSPLD LLPIAPSNLP MPGGNSTFNQ 420
  421 QVRAKVREIE EQIKERGQAV EFRWSFDKCQ ETTAGFTISR VLHTLEVLDN HSFEKSDFSN 480
  481 SLDSLYNRIF GSGQSKDGHE MSPDDDAVVT LLCEWAVSCK RSGPHRAMVV AKLLEKRQTE 540
  541 IEAERCGESE VVDEKGSVSS GSLSAATLPV FQDVLLQFLD TQAPVLTEPG NESERVEFSN 600
  601 LVLLFYELIR HDVFSHNIYM CTLISRGDLA SNSHLPRPRS PSDEPSDESE RKDQDAGSSV 660
  661 KMEDTGMSES MEIDHNSSAN FDEMFSPPMH CESKGSPSPE KQAQEQESKS TAKDKGMDPA 720
  721 FPLVYEQPRH IQYATHFPIP QEESASHECN QRLVVLYGVG KQRDEARHAI KKITKDILKV 780
  781 LNRKSTAETG GEEGQKRKRS KPEAFPTAED IFSKFQHLSH FDQHQVTSQV SRNVLEQITS 840
  841 FALGMSYHLP LVQHIQFIFD LMEYSLNISG LIDFAIQLLN ELSLVEAELL LKSSNLAGSY 900
  901 TTGLCLCIVA VLRRYHSCLI LNPDQTAQVF DGLRIVVKSG VNPADCSSAE RCILAYLYDL 960
  961 YTSCSHLKSK FGEIFSEFCS KVKNSIYYNI DPSDSNMLWD QMFMIDAITN PTAHNLNHSM1020
 1021 LGKITNELND SPANRYSFVC NVLMDVCVDH RDPERVNDIG ILCAELTAYC RSLSAEWLGV1080
 1081 LKALCCSSNN GNCGFNDLLC NVDVSDLSFH DSLATFVAIL IARQCLLLED LVRCVAIPSL1140
 1141 LNAACSEQDS EPGARLTCRI LLHLFRTPQR NPCPQDGTKS DKSIVGIRSS CDRHLLAASQ1200
 1201 NSIVVGAVFA VLKAVFMLGD AELKGSGFSH PAGLDDIGED DMGSKKSGGR NVSIETASLV1260
 1261 VYAKYVLKSI CHQEWVGERC LKSLSEDSSA LQDPVLVNIQ AQRLLQLICY PHRQLDSEEG1320
 1321 DNPQRQRIKR ILQNMDQWTM RQSSLELQLM IKQSSNNELY SLLENIAKAT IEVFQKSAEM1380
 1381 NSSNPSWNGS AVSGSSVSNS NSASKLKPVL SSSERSGVWL VAPLIGKLPT SVQGHVLKAA1440
 1441 GEELEKGQHL GPSSRKERDR QKQKSMSLLS QQPFLSLVLT CLKGQDEQRE GLLTSLYSQV1500
 1501 QQIVTNWRED QYQDDCKAKQ MMHEALKLRL NLVGGMFDTV QRSTQQTTEW AVLLLDIISS1560
 1561 GTVDMQSNNE LFTTVLDMLS VLINGTLAAD MSSISQGSME ENKRAYMNLV KKLRKELGDR1620
 1621 QSESLEKVRQ LLPLPKQTRD VITCEPQGSL IDTKGNKIAG FEKEGLQVST KQKISPWDVF1680
 1681 EGLKHSAPLS WGWFGTIRVD RKVTKFEEQQ RLLLYHTHIK PKQRSYYLAP LNLPQEEEEP1740
 1741 LTPVPPEPDK KLDTAKVEKS VSNVPTKKKK KKPASTVKQE DYKPHNTVMQ YAPGMTPDLP1800
 1801 LSMGQTNMSY RMGYQAPMNM YAQNQPLPPG GPGLEPPFRP RVPMNKMPPR PNYTMPNMQT1860
 1861 AGMGNLMGME KQYQMNYKPM PNMAQGQMLR HQLQGHNHLI GQQIRQVTPN PQYSSMQPAQ1920
 1921 NIPQGYTSYG SHMGMQPHPS QTPGMVPNSY GNQGFQTGHP ATNPTMVDSI RQMQQRPGYV1980
 1981 HQQAPAAYGH TIQSTQRFPH QSMQQTPMMH GLAQSHLGVQ GIHPNMRPNQ MMEQQQQQQQ2040
 2041 QQQQQQQQQQ QVHQQQQHIR QGPVFRPQQQ QQVQQQVQQQ VQQQQVQQQQ VQQQVQPQQV2100
 2101 QQQQVQQQQQ QQVSAAQPPA QALGMQALPP QQPMFQRQGM QQTQQQQQTA ALVRQLQQQL2160
 2161 SSTQPAQNNS SYY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

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