Protein Overview: TLG1

General Information:
Name(s) found:	TLG1 / YDR468C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|927753\|gb\|AAB64925.1\| Ydr468cp; CAI: 0.19 [Saccharomyces cerevisiae] [NCBI NR] gi\|6320676\|ref\|NP_010756.1\| Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; Tlg1p [Saccharom [NCBI NR] gi\|49036482\|sp\|Q03322.1\|TLG1_YEAST RecName: Full=T-SNARE affecting a late Golgi compartment protein 1; AltName: Full=Syntaxin TLG1 [NCBI NR] gi\|45270246\|gb\|AAS56504.1\| YDR468C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S69635 hypothetical protein YDR468c - yeast (Saccharomyces cerevisiae) [NCBI NR] T-SNARE affecting a late Golgi compartment protein 1 OS=Saccharomyces cerevisiae GN=TLG1 PE=1 SV=1 [Swiss-Prot] TLG1 Member of the syntaxin family of t-SNAREs [mips] Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p [SGD] TLG1, Chr IV from 1398015-1398689, reverse complement [yeast_orfs2] Chr IV from 1398015-1398689, reverse complement [yeastorf3.fasta] Chr IV from 1398014-1398688, reverse complement [yeastorf4.fasta] Chr IV from 1398688-1398014, reverse complement [yeastorf5.fasta] >Q03322 (Q03322) D8035.11P [4932.FASTACCERV.txt] TLG1 SGDID:S0002876, Chr IV from 1398688-1398014, reverse complement, Verified ORF [yeastflysequest.fasta] TLG1 SGDID:S0002876, Chr IV from 1398690-1398016, reverse complement, Verified ORF [10112005cervSGD.fasta] Ydr468cp; CAI: 0.19 [Saccharomyces cerevisiae]gi\|6320676\|ref\|NP_010756.1\| Tlg1p [Saccharomyces cerevisiae]gi\|49036482\|sp\|Q03322\|TLG1_YEAST T-SNARE affecting a late Golgi compartment protein 1 (Syntaxin TLG1)gi\|2131512\|pir\|\|S69635 hypothetical protein Y [nrdb_11152004_Chlamydomonas] (Q03322) T-SNARE affecting a late Golgi compartment protein 1 (Syntaxin TLG1) [cerv4932.FASTAC] TLG1 SGDID:S000002876, Chr IV from 1398690-1398016, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fif [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TLG1 SGDID:S000002876, Chr IV from 1398692-1398018, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fif [yeast-contam.fasta] TLG1 SGDID:S000002876, Chr IV from 1398693-1398019, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fif [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YDR468C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ydr468cp; CAI: 0.19 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] T-SNARE affecting a late Golgi compartment protein 1 (Syntaxin TLG1) [nr-271106-contam.fasta] Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; Tlg1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TLG1 SGDID:S000002876, Chr IV from 1398693-1398019, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" [yeast-bovrabprots.fasta] TLG1 SGDID:S000002876, Chr IV from 1398692-1398018, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" [yeast-contam_custom.fasta] [chemostatdb.fasta] T-SNARE affecting a late Golgi compartment protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TLG1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TLG1 SGDID:S000002876, Chr IV from 1398700-1398026, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" [yeast-030211-contam.fasta] TLG1 SGDID:S000002876, Chr IV from 1398700-1398026, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" [20141208_orf_trans.fasta] YDR468C SGDID:S000002876, Chr IV from 1398700-1398026, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] t-SNARE affecting a late Golgi compartment protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TLG1 PE=1 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	224 amino acids
Gene Ontology:
Cellular Component:	early endosome [TAS] trans-Golgi network [TAS] Golgi trans cisterna [TAS]
Biological Process:	vesicle fusion [TAS]
Molecular Function:	receptor signaling protein serine/threonine kinase activity [IDA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNSEDPFQQ VVKDTKEQLN RINNYITRHN TAGDDDQEEE IQDILKDVEE TIVDLDRSII  60
   61 VMKRDENEDV SGREAQVKNI KQQLDALKLR FDRRIQESTQ TTIPLEETVE NSTLNTSMAE 120
  121 NNDGGMSNPF QEQMLREQDV HLDGIHKTMQ NLHIQAQTMG DELENQGQLL DNMDEGMDGV 180
  181 VNKLARGRRQ LEWVYEKNKE KYDDCCIGLL IVVLIVLLVL AFIA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		PEP12 SEC20 SED5 SSO1 SSO2 TLG1 TLG2 UFE1
View Details	Gavin AC, et al. (2002)		SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
View Details	Qiu et al. (2008)		DRS2 PEP12 SEC22 SED5 SNC1 SNC2 SSO1 SSO2 TLG1 TLG2 VTI1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ALG13	No Comments	Hazbun TR, et al. (2003)
View Run	VAM3	Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control).	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..93] [140..224]	PSI-BLAST	29.0	Syntaxin 1A N-terminal domain
2	View Details	[94..139]	PSI-BLAST	29.0	Syntaxin 1A N-terminal domain

Protein Overview: TLG1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: