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Protein Overview: ECM14

General Information:
Name(s) found: ECM14 / YHR132C [SGD]
Description(s) found:
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  • gi|731716|sp|P38836.1|ECM14_YEAST RecName: Full=Protein ECM14; AltName: Full=Extracellular mutant protein 14; Flags: Precursor [NCBI NR]
  • gi|6321924|ref|NP_012000.1| Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly; Ecm14p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48976 ECM14 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|500682|gb|AAB68415.1| Ecm14p [Saccharomyces cerevisiae] [NCBI NR]
  • (P38836) Hypothetical 49.8 kDa protein in ACT3-YCK1 intergenic region precursor [Swiss-Prot]
  • Protein ECM14 OS=Saccharomyces cerevisiae GN=ECM14 PE=1 SV=1 [Swiss-Prot]
  • ECM14 Protein involved in cell wall biogenesis and architecture [mips]
  • Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly [SGD]
  • ECM14, Chr VIII from 368503-369795, reverse complement [yeast_orfs2]
  • Chr VIII from 368503-369795, reverse complement [yeastorf3.fasta]
  • Chr VIII from 369795-368503, reverse complement [yeastorf5.fasta]
  • ECM14 SGDID:S0001174, Chr VIII from 369795-368503, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ECM14 SGDID:S0001174, Chr VIII from 369796-368504, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Ecm14p [Saccharomyces cerevisiae]gi|500682|gb|AAB68415.1| Ecm14p [Saccharomyces cerevisiae]gi|626655|pir||S48976 ECM14 protein - yeast (Saccharomyces cerevisiae)gi|731716|sp|P38836|YHT2_YEAST Hypothetical 49.8 kDa protein in ACT3-YCK1 intergenic region [nrdb_11152004_Chlamydomonas]
  • ECM14 SGDID:S000001174, Chr VIII from 369797-368505, reverse complement, Verified ORF, "Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ecm14p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Extracellular matrix protein 14 precursor [nr-271106-contam.fasta]
  • Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly; Ecm14p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Putative metallocarboxypeptidase ECM14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM14 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ECM14 SGDID:S000001174, Chr VIII from 369794-368502, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly" [yeast-030211-contam.fasta]
  • ECM14 SGDID:S000001174, Chr VIII from 369794-368502, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly" [20141208_orf_trans.fasta]
  • TR5942|c0_g1_i1|g.4132 ORF TR5942|c0_g1_i1|g.4132 TR5942|c0_g1_i1|m.4132 type:complete len:431 (+) TR5942|c0_g1_i1:63-1355(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YHR132C SGDID:S000001174, Chr VIII from 369794-368502, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_7915|g.4901 ORF ID=asmbl_7915|g.4901 ID=asmbl_7915|m.4901 type:complete len:431 (+) ID=asmbl_7915:59-1351(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: proteolysis [ISSLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    Molecular Function: metalloendopeptidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHMNSLWGC FLFVLLAVTG AVQGLQEDYS EYAVYRFTSD NYSTLVRDVI APLTDDYDVW  60
   61 TRSNNFIDIK LPKEIGEQIN DGQVIIDNMN ELIQNTLPTS QMMAREQAVF ENDYDFFFNE 120
  121 YRDLDTIYMW LDLLERSFPS LVAVEHLGRT FEGRELKALH ISGNKPESNP EKKTIVITGG 180
  181 IHAREWISVS TVCWALYQLL NRYGSSKKET KYLDDLDFLV IPVFNPDGYA YTWSHDRLWR 240
  241 KNRQRTHVPQ CLGIDIDHSF GFQWEKAHTH ACSEEYSGET PFEAWEASAW YKYINETKGD 300
  301 YKIYGYIDMH SYSQEILYPY AYSCDALPRD LENLLELSYG LSKAIRSKSG RNYDVISACK 360
  361 DRGSDIFPGL GAGSALDFMY HHRAHWAFQL KLRDTGNHGF LLPPENIKPV GKETYAALKY 420
  421 FCDFLLDPEI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ECM14 PRC1 VMA9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] PSI-BLAST 583.0103 Carboxypeptidase A; Procarboxypeptidase A
    2 View Details [90..430] PSI-BLAST 583.0103 Carboxypeptidase A; Procarboxypeptidase A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.786910294594 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40766568731738 bayes_pls_golite062009
  • hydrolase activity
    		•  4.23257784904124 bayes_pls_golite062009
  • exopeptidase activity
    		•  3.28577934113028 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.76103081380105 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  2.63658263814587 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  1.76058821499096 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  1.56827526553175 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • binding
    		•  1.18091528890016 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.910234727191613 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.596149133958797 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.578572340123331 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.328807457631995 bayes_pls_golite062009
  • protein binding
    		•  0.215930537243465 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle