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Protein Overview: DCN1

General Information:
Name(s) found: DCN1 / YLR128W [SGD]
Description(s) found:
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  • gi|995690|emb|CAA62639.1| L3111 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|73919220|sp|Q12395.1|DCN1_YEAST RecName: Full=Defective in cullin neddylation protein 1 [NCBI NR]
  • gi|6323157|ref|NP_013229.1| Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain; Dcn1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59316 hypothetical protein YLR128w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1360537|emb|CAA97697.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1297042|emb|CAA61706.1| L3111 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1256868|gb|AAB82374.1| Ylr128wp [Saccharomyces cerevisiae] [NCBI NR]
  • Defective in cullin neddylation protein 1 OS=Saccharomyces cerevisiae GN=DCN1 PE=1 SV=1 [Swiss-Prot]
  • DCN1 Protein is required for cullin neddylation [mips]
  • Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation [SGD]
  • YLR128W, Chr XII from 398531-398533,398628-399434 [yeast_orfs2]
  • Chr XII from 398531-398533,398628-399434 [yeastorf3.fasta]
  • >Q12395 (Q12395) ORF YLR128W [4932.FASTACCERV.txt]
  • YLR128W SGDID:S0004118, Chr XII from 398531-398533,398628-399434, Uncharacterized ORF [yeastflysequest.fasta]
  • DCN1 SGDID:S0004118, Chr XII from 398531-398533,398628-399434, Uncharacterized ORF [10112005cervSGD.fasta]
  • Dcn1p [Saccharomyces cerevisiae]gi|1297042|emb|CAA61706.1| L3111 [Saccharomyces cerevisiae]gi|1360537|emb|CAA97697.1| unnamed protein product [Saccharomyces cerevisiae]gi|995690|emb|CAA62639.1| L3111 [Saccharomyces cerevisiae]gi|1363707|pir||S59316 hy [nrdb_11152004_Chlamydomonas]
  • (Q12395) L3111 protein (ORF YLR128w) (Ylr128wp) [cerv4932.FASTAC]
  • DCN1 SGDID:S000004118, Chr XII from 398531-398533,398628-399434, Verified ORF, "Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • L3111 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Defective in cullin neddylation protein 1 [nr-271106-contam.fasta]
  • Ylr128wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain; Dcn1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Defective in cullin neddylation protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCN1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DCN1 SGDID:S000004118, Chr XII from 398530-398532,398627-399433, Genome Release 64-1-1, Verified ORF, "Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation" [yeast-030211-contam.fasta]
  • DCN1 SGDID:S000004118, Chr XII from 398530-398532,398627-399433, Genome Release 64-2-1, Verified ORF, "Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation" [20141208_orf_trans.fasta]
  • YLR128W SGDID:S000004118, Chr XII from 398530-398532,398627-399433, Genome Release 64-1-1, Verified ORF, "Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: positive regulation of ubiquitin-protein ligase activity [IMPLink to PubMed article][IPILink to PubMed article]
    protein neddylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: enzyme activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNKIKRKD ASPEQEAIES FTSLTKCDPK VSRKYLQRNH WNINYALNDY YDKEIGTFTD  60
   61 EVSTVAHPPV YPKELTQVFE HYINNNLFDI DSLVKFIEEL GYNLEDLATL CLAHLLGYKK 120
  121 LEEPLKREDF LSTWFMQGCS TISDMQECIK TLDVKLHEDL QYFTQIYNYA FNLILDPNRK 180
  181 DIDTDEGIQY WKLFFQPEYP VRMEPDLLEA WFRFLRDEGK TTISKDTWRM LLLFFKRYPT 240
  241 IQKIISDYDE TAAWPFIIDE FYECLQDQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DCN1 KAR9 2 Unpublished Fields Lab Data
    View Screen CDC53 DCN1 2 Uetz P, et al. (2000)
    View Screen DCN1 RHB1 2 Unpublished Fields Lab Data
    View Screen DCN1 YIR014W 2 Unpublished Fields Lab Data
    View Screen DCN1 MHP1 2 Unpublished Fields Lab Data
    View Screen DCN1 GMH1 2 Unpublished Fields Lab Data
    View Screen DCN1 DFG5 2 Unpublished Fields Lab Data
    View Screen DCN1 YNL247W 2 Unpublished Fields Lab Data
    View Screen DCN1 SMA1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] deduced N/A No confident structure predictions are available.
    2 View Details [125..269] Pfam 68.075721 Domain of unknown function (DUF298) No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle