Protein Overview: TEP1

General Information:
Name(s) found:	TEP1 / YNL128W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|854509\|emb\|CAA86897.1\| tyrosine phosphatase (putative) [Saccharomyces cerevisiae] [NCBI NR] gi\|6324201\|ref\|NP_014271.1\| Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation; Tep1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1730775\|sp\|P53916.1\|TEP1_YEAST RecName: Full=Probable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1 [NCBI NR] gi\|1302064\|emb\|CAA96010.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S55155 probable tyrosine phosphatase YNL128w - yeast (Saccharomyces cerevisiae) [NCBI NR] (P53916) Hypothetical 50.2 kDa protein in CPT1-SPC98 intergenic region [Swiss-Prot] Probable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae GN=TEP1 PE=1 SV=1 [Swiss-Prot] TEP1 Protein involved in developmental trafficking phosphatidylinositol pathway [mips] Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation [SGD] TEP1, Chr XIV from 382356-383660 [yeast_orfs2] Chr XIV from 382356-383660 [yeastorf3.fasta] TEP1 SGDID:S0005072, Chr XIV from 382359-383663, Verified ORF [yeastflysequest.fasta] Similar to human tumor suppressor gene known as TEP1, MMAC1 and PTEN1; Putative protein tyrosine phosphatase [Saccharomyces cerevisiae]gi\|854509\|emb\|CAA86897.1\| tyrosine phosphatase (putative) [Saccharomyces cerevisiae]gi\|1302064\|emb\|CAA96010.1\| unnamed [nrdb_11152004_Chlamydomonas] TEP1 SGDID:S000005072, Chr XIV from 382361-383665, Verified ORF, "Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Probable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1 [nr-271106-contam.fasta] Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation; Tep1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] tyrosine phosphatase (putative) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEP1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TEP1 SGDID:S000005072, Chr XIV from 382359-383663, Genome Release 64-1-1, Verified ORF, "Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation" [yeast-030211-contam.fasta] TEP1 SGDID:S000005072, Chr XIV from 382359-383663, Genome Release 64-2-1, Verified ORF, "PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1" [20141208_orf_trans.fasta] YNL128W SGDID:S000005072, Chr XIV from 382359-383663, Genome Release 64-1-1, Verified ORF, "Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEP1 PE=3 SV=1 [uniprot_sprot.fasta.20160308] Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEP1 PE=4 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	434 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	inositol lipid-mediated signaling [IMP] ascospore wall assembly [IMP] phosphoinositide dephosphorylation [IDA]
Molecular Function:	inositol or phosphatidylinositol phosphatase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN LIVCSYPVNT  60
   61 YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY KDNDLIGIAA KFESKDFEIQ 120
  121 ELRSTLINDG KIPISPIDLE TRTLVEEETN NVICERIGWL DHFPPPFELL EEIVDGIENY 180
  181 LSVSKNRVAV LHCRMGKGRS GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS 240
  241 QLRYLRYHEF FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH 300
  301 YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT SKSKAASSII 360
  361 SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM LGTTISWQEL DGFGELSTHG 420
  421 LKLFQALKLE WEII

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ILV2 MLH3 MLP2 TEP1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TEP1	RSA1	2	Unpublished Fields Lab Data
View Screen	TEP1	ORC4	2	Unpublished Fields Lab Data
View Screen	TEP1	APL2	2	Unpublished Fields Lab Data
View Screen	TEP1	DBP1	2	Unpublished Fields Lab Data
View Screen	TEP1	YDL050C	2	Unpublished Fields Lab Data
View Screen	TEP1	APL2	2	Unpublished Fields Lab Data
View Screen	TEP1	APL2	2	Unpublished Fields Lab Data
View Screen	TEP1	OSW2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..158] [176..197]	PSI-BLAST	187.69897	Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
2	View Details	[159..175] [198..324]	PSI-BLAST	187.69897	Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
3	View Details	[325..434]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.89

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2