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Protein Overview: P4HA1

General Information:
Name(s) found: P4HA1 [HGNC (HUGO)]
Description(s) found:
Found 36 descriptions.
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  • prolyl 4-hydroxylase, alpha polypeptide I [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA  60
   61 EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY 120
  121 FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS FLTAEDCFEL GKVAYTEADY 180
  181 YHTELWMEQA LRQLDEGEIS TIDKVSVLDY LSYAVYQQGD LDKALLLTKK LLELDPEHQR 240
  241 ANGNLKYFEY IMAKEKDVNK SASDDQSDQK TTPKKKGVAV DYLPERQKYE MLCRGEGIKM 300
  301 TPRRQKKLFC RYHDGNRNPK FILAPAKQED EWDKPRIIRF HDIISDAEIE IVKDLAKPRL 360
  361 RRATISNPIT GDLETVHYRI SKSAWLSGYE NPVVSRINMR IQDLTGLDVS TAEELQVANY 420
  421 GVGGQYEPHF DFARKDEPDA FKELGTGNRI ATWLFYMSDV SAGGATVFPE VGASVWPKKG 480
  481 TAVFWYNLFA SGEGDYSTRH AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] Pfam 75.075721 No description for PF08336.2 was found. No confident structure predictions are available.
    2 View Details [162..283] PSI-BLAST 5.0 Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase
    3 View Details [284..369] PSI-BLAST 14.69897 PP5 structure
    4 View Details [370..534] FFAS03 4.63 No description for 2hbtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  7.0422525853653 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  5.01373106146099 bayes_pls_golite062009
  • binding
    		•  2.09193012129784 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.534990536504941 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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