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Protein Overview: MMP2

General Information:
Name(s) found: MMP2 [HGNC (HUGO)]
Description(s) found:
Found 41 descriptions.
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  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 660 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC  60
   61 PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 120
  121 KNQITYRIIG YTPDLDPETV DDAFARAFQV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 180
  181 GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 240
  241 GKEYNSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT 300
  301 SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 360
  361 ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 420
  421 MAPIYTYTKN FRLSQDDIKG IQELYGASPD IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ 480
  481 IRGEIFFFKD RFIWRTVTPR DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY 540
  541 WIYSASTLER GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP 600
  601 GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF GSIKSDWLGC 660
  661

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..660] PSI-BLAST 1000.0 Gelatinase A (MMP-2); Gelatinase A (MMP-2), C-terminal domain; Gelatinase A; Gelatinase A (MMP-2) type II modules

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • fibronectin binding
    		•  3.98501508968372 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.43236442601127 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55673800115122 bayes_pls_golite062009
  • integrin binding
    		•  2.21480172712354 bayes_pls_golite062009
  • exopeptidase activity
    		•  2.07461908743946 bayes_pls_golite062009
  • receptor binding
    		•  2.07222569254168 bayes_pls_golite062009
  • protein complex binding
    		•  1.73407494465529 bayes_pls_golite062009
  • protein binding
    		•  1.58118182554863 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.994405248731328 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • zinc ion binding
    		•  0.49304764842799 bayes_pls_golite062009
  • heparin binding
    		•  0.47163706628903 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.46452174183235 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • growth factor activity
    		•  0.259654587796416 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.21514043665594 bayes_pls_golite062009
  • signal transducer activity
    		•  0.120905338073793 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.120905338073793 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  0.0679084139446893 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  0.0344783818483405 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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