Protein Overview: PLCG2_MOUSE

General Information:
Name(s) found:	PLCG2_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81878210\|sp\|Q8CIH5.1\|PLCG2_MOUSE RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2 [NCBI NR] gi\|26986603\|ref\|NP_758489.1\| phospholipase C, gamma 2 [Mus musculus] [NCBI NR] gi\|23271777\|gb\|AAH23877.1\| Phospholipase C, gamma 2 [Mus musculus] [NCBI NR] 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Mus musculus GN=Plcg2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):8-117092892 Similar to phospholipase C, gamma 2 [hmr_yeast5_DM3-1_pombe.fasta] phospholipase C, gamma 2 [HMR_022704-rand.fasta] Phospholipase C, gamma 2 [ipi.MOUSE.v3.06.fasta] phospholipase C, gamma 2 [Mus musculus]gi\|23271777\|gb\|AAH23877.1\| Phospholipase C, gamma 2 [Mus musculus] [nrdb_11152004_Chlamydomonas] phospholipase C, gamma 2 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Tax_Id=10090 Phospholipase C, gamma 2 [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta] 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (Phosphoinositide phospholipase C) (Phospholipase C-gamma-2) (PLC-gamma-2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Phospholipase C, gamma 2 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 PHOSPHOLIPASE C, GAMMA 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Plcg2 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [mouse-ipi-250309-contam.fasta] 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00229848.3\|SWISS-PROT:Q8CIH5\|ENSEMBL:ENSMUSP00000079991\|REFSEQ:NP_758489 Tax_Id=10090 Gene_Symbol=Plcg2 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [ipi.MOUSE.fasta.20090209] 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 OS=Mus musculus GN=Plcg2 [011711_HMR.fasta] 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 OS=Mus musculus GN=Plcg2 PE=1 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta] sp\|Q8CIH5\|PLCG2_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Mus musculus GN=Plcg2 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1265 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [UNKNOWN]
Biological Process:	signal transduction [IEA] response to ATP [UNKNOWN] phospholipid catabolic process [IEA] negative regulation of programmed cell death [IMP] elevation of cytosolic calcium ion concentration [UNKNOWN] intracellular signaling pathway [IEA] follicular B cell differentiation [IMP] inositol trisphosphate biosynthetic process [IDA] lipid catabolic process [IEA] lipid metabolic process [IEA] regulation of gene expression [IMP] response to magnesium ion [UNKNOWN] response to lipopolysaccharide [IDA] T cell receptor signaling pathway [IDA] activation of store-operated calcium channel activity [IMP]
Molecular Function:	phosphoinositide phospholipase C activity [UNKNOWN] protein binding [IPI] phospholipase C activity [TAS] phosphoric diester hydrolase activity [IEA] signal transducer activity [IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTMVNVDTL PEYEKSQIKR ALELGTVMTV FNARKSTPER RTVQMIMETR QVAWSKTADK  60
   61 IEGFLDIMEI KEIRPGKNSK DFERAKAVRH KAECCFTILY GTQFVLSTLS LATDSKEDAV 120
  121 KWLSGLKILH QEAMSASTPT MIESWLRKQI YSVDQTRRNS ISLRELKTIL PLVNFKVSGI 180
  181 KFLKDKLVEI GAQKDELSFE QFHLFYKKLM FDQQKSILDE FKKDSSVFIL GNTDRPDASA 240
  241 VYLQDFQRFL LHEQQELWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS 300
  301 IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES STEAYIRCLR AGCRCIELDC 360
  361 WDGPDGKPII YHGWTRTTKI KFDDVVQAIR DHAFVTSSFP VILSIEEHCS VEQQRHMAKV 420
  421 FKEVLGDMLL TKPTEASADQ LPSPSQLREK IIIKHKKLGP KGDVDVNVED KKDEHKPQGE 480
  481 LYMWDSIDQK WTRHYCAIAD AKLSFGDDIE QAVEEEPVQD TPPTELHFGE KWFHKKVESR 540
  541 TSAEKLLQEY CAETGAKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMENGVMKYY 600
  601 LTDNLTFNSI YALIQHYREA HLRCAEFELR LTDPVPNPNP HESKPWYYDS LSRGEAEDML 660
  661 MRIPRDGAFL IRKREGTNSY AITFRARGKV KHCRINRDGR HFVLGTSAYF ESLVELVSYY 720
  721 EKHALYRKMR LRYPVTPELL ERYNMERDIN SLYDVSRMYV DPSEINPSMP QRTVKALYDY 780
  781 KAKRSDELTF CRGALIHNVS KEPGGWWKGD YGTRIQQYFP SNYVEDISAG DAEEMEKQII 840
  841 EDNPLGSLCK GILDLNTYNV VKAPQGKNQK AFVFILEPKK QGDPPVEFAT DRVEELFEWF 900
  901 QSIREITWKM DTKENNMKYW ERNQSIAIEL SDLVVYCKPT SKTKDHLENP DFREIRSFVE 960
  961 TKADSIVRQK PVDLLRYNQK GLTRVYPKGQ RVDSSNYDPF RLWLCGSQMV ALNFQTPDKY1020
 1021 MQMNHALFSL NGRTGYVLQP ESMRSEKYDP MPLESQRKIL MTLTVKVLGA RHLPKLGRSI1080
 1081 ACPFVEVEIC GAEYDSNKFK TTVVNDNGLS PVWAPTQEKV TFEIYDPNLA FLRFVVYEED1140
 1141 MFSDPNFLAH ATYPIKGIKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC1200
 1201 RQLRRRQEEL NNQLFLYDTH QNLRGANRDA LVKEFNVNEN QLQLYQEKCN RRLREKRVSN1260
 1261 SRFYS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: PLCG2_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: