Protein Overview: RB_MOUSE

General Information:
Name(s) found:	RB_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6677679\|ref\|NP_033055.1\| retinoblastoma 1 [Mus musculus] [NCBI NR] gi\|200453\|gb\|AAA39964.1\| pp105 Rb protein [NCBI NR] gi\|132165\|sp\|P13405.1\|RB_MOUSE RecName: Full=Retinoblastoma-associated protein; AltName: Full=pRb; Short=Rb; AltName: Full=pp105 [NCBI NR] pir\|\|A33718 retinoblastoma protein - mouse [NCBI NR] Retinoblastoma-associated protein OS=Mus musculus GN=Rb1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):14-63649272 Retinoblastoma-associated protein [hmr_yeast5_DM3-1_pombe.fasta] retinoblastoma 1 [HMR_022704-rand.fasta] Retinoblastoma-associated protein [ipi.MOUSE.v3.06.fasta] retinoblastoma 1 [Mus musculus]gi\|132165\|sp\|P13405\|RB_MOUSE Retinoblastoma-associated protein (PP105) (RB)gi\|110918\|pir\|\|A33718 retinoblastoma protein - mousegi\|200453\|gb\|AAA39964.1\| pp105 Rb protein [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Retinoblastoma-associated protein [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_009029) retinoblastoma 1 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] retinoblastoma 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Retinoblastoma-associated protein (pRb) (Rb) (pp105) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] pp105 Rb protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 RETINOBLASTOMA-ASSOCIATED PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Rb1 Retinoblastoma-associated protein [mouse-ipi-250309-contam.fasta] Retinoblastoma-associated protein (PP105) (RB) [nr-271106-contam.fasta] Tax_Id=10090 Gene_Symbol=Rb1 Retinoblastoma-associated protein ENSMUSG00000022105 IPI00121418 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00121418.1\|SWISS-PROT:P13405 Tax_Id=10090 Gene_Symbol=Rb1 Retinoblastoma-associated protein [ipi.MOUSE.fasta.20090209] Retinoblastoma-associated protein OS=Mus musculus GN=Rb1 [011711_HMR.fasta]
Organism:	Mus musculus
Length:	921 amino acids
Gene Ontology:
Cellular Component:	transcription factor complex [IDA] nucleus [UNKNOWN][IDA] spindle [IDA]
Biological Process:	cell cycle arrest [IMP] chromatin modification [IEA] transcription [IEA] negative regulation of cell proliferation [IGI][IMP] negative regulation of cell cycle [IMP] enucleate erythrocyte differentiation [IGI] regulation of transcription [IEA] positive regulation of transcription from RNA polymerase II promoter [IDA][IGI][IMP] cell cycle [IEA] negative regulation of transcription from RNA polymerase II promoter [IDA][IGI] cell division [IMP] striated muscle cell differentiation [IGI] negative regulation of transcription, DNA-dependent [IDA] positive regulation of macrophage differentiation [IGI] G1/S transition of mitotic cell cycle [IMP] regulation of cell cycle [IMP]
Molecular Function:	DNA binding [IEA] protein binding [IPI] transcription factor binding [IPI] transcription repressor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKAPRRAA AAEPPPPPPP PPREDDPAQD SGPEELPLAR LEFEEIEEPE FIALCQKLKV  60
   61 PDHVRERAWL TWEKVSSVDG ILEGYIQKKK ELWGICIFIA AVDLDEMPFT FTELQKSIET 120
  121 SVYKFFDLLK EIDTSTKVDN AMSRLLKKYN VLCALYSKLE RTCELIYLTQ PSSALSTEIN 180
  181 SMLVLKISWI TFLLAKGEVL QMEDDLVISF QLMLCVVDYF IKFSPPALLR EPYKTAAIPI 240
  241 NGSPRTPRRG QNRSARIAKQ LENDTRIIEV LCKEHECNID EVKNVYFKNF IPFINSLGIV 300
  301 SSNGLPEVES LSKRYEEVYL KNKDLDARLF LDHDKTLQTD PIDSFETERT PRKNNPDEEA 360
  361 NVVTPHTPVR TVMNTIQQLM VILNSASDQP SENLISYFNN CTVNPKENIL KRVKDVGHIF 420
  421 KEKFANAVGQ GCVDIGVQRY KLGVRLYYRV MESMLKSEEE RLSIQNFSKL LNDNIFHMSL 480
  481 LACALEVVMA TYSRSTLQHL DSGTDLSFPW ILNVLNLKAF DFYKVIESFI KVEANLTREM 540
  541 IKHLERCEHR IMESLAWLSD SPLFDLIKQS KDGEGPDNLE PACPLSLPLQ GNHTAADMYL 600
  601 SPLRSPKKRT STTRVNSAAN TETQAASAFH TQKPLKSTSL ALFYKKVYRL AYLRLNTLCA 660
  661 RLLSDHPELE HIIWTLFQHT LQNEYELMRD RHLDQIMMCS MYGICKVKNI DLKFKIIVTA 720
  721 YKDLPHAAQE TFKRVLIREE EFDSIIVFYN SVFMQRLKTN ILQYASTRPP TLSPIPHIPR 780
  781 SPYKFSSSPL RIPGGNIYIS PLKSPYKISE GLPTPTKMTP RSRILVSIGE SFGTSEKFQK 840
  841 INQMVCNSDR VLKRSAEGGN PPKPLKNVRF DIEGADEADG SKHLPAESKF QQKLAEMTST 900
  901 RTRMQKQRMN ESKDVSNKEE K

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: RB_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: