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Protein Overview: KALRN_RAT

General Information:
Name(s) found: KALRN_RAT [Swiss-Prot]
Description(s) found:
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  • gi|7650390|gb|AAF66019.1|AF232669_1 Kalirin-12a [Rattus norvegicus] [NCBI NR]
  • gi|160380715|sp|P97924.3|KALRN_RAT RecName: Full=Kalirin; AltName: Full=Huntingtin-associated protein-interacting protein; AltName: Full=Protein Duo; AltName: Full=Serine/threonine kinase with Dbl- and pleckstrin homology domain; AltName: Full=PAM COOH-te [NCBI NR]
  • gi|14091744|ref|NP_114451.1| kalirin, RhoGEF kinase [Rattus norvegicus] [NCBI NR]
  • Kalirin OS=Rattus norvegicus GN=Kalrn PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):11-19939030;11-19939030 Kalirin-12a [hmr_yeast5_DM3-1_pombe.fasta]
  • huntingtin-associated protein interacting protein (duo) [HMR_022704-rand.fasta]
  • huntingtin-associated protein interacting protein (duo) [Rattus norvegicus]gi|7650390|gb|AAF66019.1| Kalirin-12a [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Kalirin-12a [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_032062) huntingtin-associated protein interacting protein (duo) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Kalirin (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine kinase with Dbl- and pleckstrin homology domain) (PAM COOH-terminal interactor protein 10) (P-CIP10) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • kalirin, RhoGEF kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Kalirin-12a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 KALIRIN-12A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Kalrn Isoform 1 of Kalirin [rat-ipi-250309-contam.fasta]
  • kalirin [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Isoform 1 of Kalirin OS=Rattus norvegicus GN=Kalrn [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 2959 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IEA]
    cytosol [UNKNOWN]
    neuronal cell body [IDA]
    neuron projection [IDA]
    intracellular [IEA]
    Biological Process: regulation of dendrite development [IDA]
    regulation of Rho protein signal transduction [IEA]
    vesicle-mediated transport [IDA]
    intracellular signaling pathway [IDA]
    axonogenesis [IDA]
    apoptosis [UNKNOWN]
    nervous system development [IDA]
    protein amino acid phosphorylation [IEA]
    induction of apoptosis by extracellular signals [UNKNOWN]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN][IDA][IPI]
    metal ion binding [IEA]
    guanyl-nucleotide exchange factor activity [UNKNOWN][TAS]
    Rho guanyl-nucleotide exchange factor activity [IEA]
    protein serine/threonine kinase activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARTNHDR IRQEDLRKLV  60
   61 TNLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA FPAEIHVALI IKPDNFWQKQ 120
  121 KTNFGSSKFI FETSMVSVEG LTKLVDPSQL TEEFDGSLDY NHEEWIELRL SLEEFFNSAV 180
  181 HLLSRLEDLQ EMLARKEFPV DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC 240
  241 SDGFSGRNCI PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD 300
  301 AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI NRIMSVASRL 360
  361 SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA VFHQKAEQFL SGVDAWCKMC 420
  421 SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY TEVSQDGKAL LDVLQRPLSP GNSESLTATA 480
  481 NYSKAVHQVL DVVHEVLHHQ RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA 540
  541 FLSKHTGVGK SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA 600
  601 ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV CADSVDAVQE 660
  661 LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP TEARDSAVSN NKTPHSSSIS 720
  721 HIESVLQQLD DAQVQMEELF HERKIKLDIF LQLRIFEQYT IEVTAELDAW NEDLLRQMND 780
  781 FNTEDLTLAE QRLQRHTERK LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDVDLA 840
  841 AQVQELLEFL HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV 900
  901 NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI RECAEKVALH 960
  961 WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR RDEDWCGGRD KLGPAAEMDH1020
 1021 VIPLLSKHLE QKEAFLKACT LARRNAEVFL KYIHRNNVSM PSVASHTRGP EQQVKAILSE1080
 1081 LLQRENRVLH FWTLKKRRLD QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET1140
 1141 QELLKEYGEF RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM1200
 1201 GKYRYTLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEVNEEKRK SARKKEFIMA1260
 1261 ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH IIFGNIQEIY DFHNNIFLKE1320
 1321 LEKYEQLPED VGHCFVTWAD KFQMYVTYCK NKPDSNQLIL EHAGTFFDEI QQRHGLANSI1380
 1381 SSYLIKPVQR VTKYQLLLKE LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE1440
 1441 NLDVQGELIL QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL1500
 1501 TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE VIQERIIHLK1560
 1561 GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT ISIASRTSQN TVESDKLSGG1620
 1621 CELTVVLQDF SAAHSSELSI QVGQTVELLE RPSERPGWCL VRTTERSPPQ EGLVPSSTLC1680
 1681 ISHSRSSVEM DCFFPLVKDS YSHSSGENGG KSESVANLQS QPSLNSIHSS PGPKRSTNTL1740
 1741 KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS ADEKSKKGWG1800
 1801 EDEPDEESHT PLPPPMKIFD NDPTQDEMSS LLAARQAPTD VPTAADLVSA IEKLVKSKLT1860
 1861 LEGGSYRGSL KDPTVCLNEG MAPPTPPRNL EEEQKAKALR GRMFVLNELV QTEKDYVKDL1920
 1921 GIVVEGFMKR IEEKGVPEDM RGKEKIVFGN IHQIYDWHKD FFLAELEKCI QEQDRLAQLF1980
 1981 IKHERKLHIY VWYCQNKPRS EYIVAEYDAY FEEVKQEINQ RLTLSDFLIK PIQRITKYQL2040
 2041 LLKDFLRYSE KAGLECSDIE KAVELMCLVP KRCNDMMNLG RLQGFEGTLT AQGKLLQQDT2100
 2101 FYVIELDAGM QSRTKERRVF LFEQIVIFSE LLRKGSLTPG YMFKRSIKMN YLVLEEDVDD2160
 2161 DPCKFALMNR ETSERVILQA ANSDIQQAWV QDINQVLETQ RDFLNALQSP IEYQRKERST2220
 2221 AVIRSQPPRV PQASPRPYSS VPVGSEKPPK GSSYNPPLPP LKISTSNGSP GFDYHQPGDK2280
 2281 FDASKQNDLG GCNGTSTMAV IKDYYALKEN EICVSQGEVV QVLAVNQQNM CLVYQPASDH2340
 2341 SPAAEGWVPG SILAPLTKAT APAESSDESI KKSCSWHTLR MRKRADVENT GKNEATGPRK2400
 2401 PKDILGNKAS VKETNSSEES ECDDLDPNTS MEILNPNFIQ EVAPEFLVPL VDVTCLLGDT2460
 2461 VLLQCKACGR PKPTITWKGP DQNILDTDNS SATYTISSCD SGESTLKICN LMPQDSGIYT2520
 2521 CIATNDHGTA STSATVKVQG VPAAPNRPIA QERSCTSVIL RWLPPASTGN CTISGYTVEY2580
 2581 REEGSQVWQQ SVASTLDTYL VIEDLSPGCP YQFRVSASNP WGISLPSEPS EFVHLPEYDA2640
 2641 AADGATISWK ENFDSAYTEL NEIGRGRFSI VKKCIHKATR KDVAVKFVSK KMKKKEQAAH2700
 2701 EAALLQHLQH PQYVTLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME EKVAFYIRDI2760
 2761 MEALQYLHNC RVAHLDIKPE NLLIDLRIPV PRVKLIDLED AVQISGHFHI HHLLGNPEFA2820
 2821 APEVIQGIPV SLGTDIWSIG VLTYVMLSGV SPFLDESKEE TCINVCRVDF SFPHEYFCGV2880
 2881 SNAARDFINV ILQEDFRRRP TAATCLQHPW LQPHNGSYSK IPLDTSRLAC FIERRKHQND2940
 2941 VRPIPNVKSY IVNRVNQGT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle