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Protein Overview: HAND2_RAT

General Information:
Name(s) found: HAND2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|47117685|sp|P61295.1|HAND2_RAT RecName: Full=Heart- and neural crest derivatives-expressed protein 2; AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; Short=dHAND [NCBI NR]
  • gi|4150890|emb|CAA69332.1| dHand protein [Rattus norvegicus] [NCBI NR]
  • gi|12083653|ref|NP_073187.1| heart and neural crest derivatives expressed 2 [Rattus norvegicus] [NCBI NR]
  • Heart- and neural crest derivatives-expressed protein 2 OS=Rattus norvegicus GN=Hand2 PE=2 SV=1 [Swiss-Prot]
  • (P61295) Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Heart- and neural crest derivatives-expressed protein 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • dHand protein [HMR_022704-rand.fasta]
  • dHand protein [Rattus norvegicus]gi|12545384|ref|NP_068808.1| basic helix-loop-helix transcription factor HAND2 [Homo sapiens]gi|4150890|emb|CAA69332.1| dHand protein [Rattus norvegicus]gi|47117899|sp|Q61039|HAN2_MOUSE Heart- and neural crest derivativ [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Heart- and neural crest derivatives-expressed protein 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_022696) dHand protein [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • heart and neural crest derivatives expressed transcript 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • dHand protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • heart and neural crest derivatives expressed 2 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Hand2 Heart- and neural crest derivatives-expressed protein 2 [rat-ipi-250309-contam.fasta]
  • Heart- and neural crest derivatives-expressed protein 2 OS=Rattus norvegicus GN=Hand2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 217 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    transcription factor complex [IEA]
    Biological Process: heart development [UNKNOWN]
    heart morphogenesis [UNKNOWN]
    angiogenesis [IEA]
    in utero embryonic development [UNKNOWN][IEA]
    multicellular organismal development [IEA]
    neural crest cell development [UNKNOWN][IEA]
    apoptosis [UNKNOWN][IEA]
    cell differentiation [IEA]
    heart looping [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    adult heart development [UNKNOWN][IEA]
    Molecular Function: transcription factor activity [IMP]
    protein domain specific binding [IDA]
    protein binding [UNKNOWN]
    protein homodimerization activity [TAS]
    transcription coactivator activity [IMP]
    protein heterodimerization activity [UNKNOWN][TAS]
    transcription factor binding [IPI]
    transcription activator activity [IDA]
    transcription activator binding [IPI]
    E-box binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM  60
   61 ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA 120
  121 ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK 180
  181 RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..217] PSI-BLAST 18.221849 Myc prot-oncogene protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.58751248599889 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.03674713048499 bayes_pls_golite062009
  • promoter binding
    		•  1.56457725225443 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.39260472877067 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.3655541712365 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.29436315000437 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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