Protein Overview: OGA_RAT

General Information:
Name(s) found:	OGA_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81867293\|sp\|Q8VIJ5.1\|NCOAT_RAT RecName: Full=Bifunctional protein NCOAT; AltName: Full=Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; AltName: Full=Meningioma-expressed antigen 5; Includes: RecName: Full=Beta-hexosaminidase; AltName: Full=N-ace [NCBI NR] gi\|18777747\|ref\|NP_571979.1\| meningioma expressed antigen 5 (hyaluronidase) [Rattus norvegicus] [NCBI NR] gi\|16943639\|gb\|AAK72103.1\| O-GlcNAcase [Rattus norvegicus] [NCBI NR] Protein O-GlcNAcase OS=Rattus norvegicus GN=Mgea5 PE=1 SV=1 [Swiss-Prot] Bifunctional protein NCOAT OS=Rattus norvegicus GN=Mgea5 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):1-252964729;1-252964729 O-GlcNAcase [hmr_yeast5_DM3-1_pombe.fasta] meningioma expressed antigen 5 (hyaluronidase) [HMR_022704-rand.fasta] meningioma expressed antigen 5 (hyaluronidase) [Rattus norvegicus]gi\|16943639\|gb\|AAK72103.1\| O-GlcNAcase [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 O-GlcNAcase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_131904) meningioma expressed antigen 5 (hyaluronidase) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta-hexosaminidase (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D-glucosamin [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] meningioma expressed antigen 5 (hyaluronidase) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] O-GlcNAcase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 O-GLCNACASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Mgea5 Isoform 1 of Bifunctional protein NCOAT [rat-ipi-250309-contam.fasta] bifunctional protein NCOAT [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Isoform 1 of Bifunctional protein NCOAT OS=Rattus norvegicus GN=Mgea5 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	916 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA] cytoplasm [IEA] mitochondrion [IDA]
Biological Process:	positive regulation of growth hormone secretion [IMP] negative regulation of protein amino acid glycosylation [IMP] metabolic process [IEA] positive regulation of calcium ion transport [IMP] positive regulation of protein complex disassembly [IMP] positive regulation of glucose import [IMP] N-acetylglucosamine metabolic process [IMP] positive regulation of proteolysis [IMP] response to steroid hormone stimulus [IEP] aging [IEP] protein targeting to membrane [IMP] necrotic cell death [IMP] negative regulation of cardiac muscle adaptation [IMP] positive regulation of DNA metabolic process [IMP] positive regulation of cell killing [IMP] positive regulation of mitochondrial depolarization [IMP] positive regulation of calcium ion transport into cytosol [IMP] positive regulation of insulin secretion [IMP] dATP metabolic process [IMP]
Molecular Function:	histone acetyltransferase activity [IMP] beta-N-acetylglucosaminidase activity [IDA] transferase activity [IEA] beta-N-acetylhexosaminidase activity [IEA] acyltransferase activity [IEA] hydrolase activity, acting on glycosyl bonds [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQKESQAAL EERESERNAN PASVSGASLE PSAAPAPGED NPSGAGAAAG TGAAGGARRF  60
   61 LCGVVEGFYG RPWVMEQRKE LFRRLQKWEL NTYLYAPKDD YKHRMFWREM YSVEEAEQLM 120
  121 TLISAAREYE IEFIYAISPG LDITFSNPKE VSTLKRKLDQ VSQFGCRSFA LLFDDIDHNM 180
  181 CAADKEVFSS FAHAQVSITN EIYQYLGEPE TFLFCPTEYC GTFCYPSVSQ SPYLRTVGEK 240
  241 LLPGIEVLWT GPKVVSKEIP VESIEEVSKI IKRAPVIWDN IHANDYDQKR LFLGPYKGRS 300
  301 TELIPRLKGV LTNPNCEFEA NYVAIHTLAT WYKSNMNGVR KDVVMTDSED STVSIQIKLE 360
  361 NEGSDEDIET DVLYSPQMAL KLALTEWLQE FGVPHQYSSR QVAHSGAKTS VVDGTPLVAA 420
  421 PSLNATTVVT TVYQEPIMSQ GAALSGEPSA LTKEEEKKQP DEEPMDMVVE KQEESEHKSD 480
  481 NQILTEIVEA KMAEELKPMD TDKESIAESK SPEMSMQEDC INDIAPMQTD EQANKEQFVP 540
  541 GPNEKPLYAA EPVTLEDLQL LADLFYLPYE HGPKGAQMLR EFQWLRANSS VVSVNCKGKD 600
  601 SEKIEEWRSR AAKFEEMCAL VMGMFTRLSN CANRTILYDM YSYVWDIKSI MSMVKSFVQW 660
  661 LGCRSHSSAQ FLIGDQEPWA FRGGLAGEFQ RLLPIDGAND LFFQPPPLTP TSKVYTIRPY 720
  721 FPKDEASVYK ICREMYDDGV GLPFQSQPDL IGDKLVGGLL SLSLDYCFVL EDEDGICGYA 780
  781 LGTVDVTPFI KKCKISWIPF MQEKYTKPNG DKELSEAEKI MLSFHEEQEV LPETFLANFP 840
  841 SLIKMDIHKK VTDPSVAKSM MACLLSSLKA NGSRGAFCEV RPDDKRILEF YSKLGCFEIA 900
  901 KMEGFPKDVV ILGRSL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: OGA_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: