Protein Overview: MUSK_RAT

General Information:
Name(s) found:	MUSK_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|50400717\|sp\|Q62838.1\|MUSK_RAT RecName: Full=Muscle, skeletal receptor tyrosine protein kinase; AltName: Full=Muscle-specific kinase receptor; Short=MuSK; Flags: Precursor [NCBI NR] gi\|13592003\|ref\|NP_112323.1\| skeletal muscle receptor tyrosine kinase [Rattus norvegicus] [NCBI NR] gi\|1015392\|gb\|AAA90956.1\| muscle-specific tyrosine kinase receptor MuSK [NCBI NR] Muscle, skeletal receptor tyrosine protein kinase OS=Rattus norvegicus GN=Musk PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):5-71673182 Muscle-specific tyrosine kinase receptor MuSK [hmr_yeast5_DM3-1_pombe.fasta] muscle, skeletal, receptor tyrosine kinase; muscle-specific tyrosine kinase receptor MuSK [HMR_022704-rand.fasta] muscle, skeletal, receptor tyrosine kinase [Rattus norvegicus]gi\|1015392\|gb\|AAA90956.1\| muscle-specific tyrosine kinase receptor MuSKgi\|50400717\|sp\|Q62838\|MUSK_RAT Muscle, skeletal receptor tyrosine protein kinase precursor (Muscle-specific kinase recep [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Muscle, skeletal receptor tyrosine protein kinase precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031061) muscle-specific tyrosine kinase receptor MuSK [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Muscle, skeletal receptor tyrosine protein kinase precursor (Muscle-specific kinase receptor) (MuSK) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] skeletal muscle receptor tyrosine kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] muscle-specific tyrosine kinase receptor MuSK [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
Organism:	Rattus norvegicus
Length:	868 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [IEA] membrane [IEA] external side of plasma membrane [IDA] neuromuscular junction [UNKNOWN][IDA] cell projection [IDA] plasma membrane [UNKNOWN]
Biological Process:	response to muscle activity [IEP] cochlea development [IEP] retina development in camera-type eye [IEP] regulation of synaptic growth at neuromuscular junction [UNKNOWN] regulation of transcription, DNA-dependent [UNKNOWN] transmembrane receptor protein tyrosine kinase signaling pathway [IEA] protein amino acid autophosphorylation [IDA] response to axon injury [IEP] receptor clustering [UNKNOWN][IMP] protein amino acid phosphorylation [IEA] memory [IMP] positive regulation of synaptic growth at neuromuscular junction [IMP] neuromuscular junction development [UNKNOWN][IEA][IEP] negative regulation of gene expression [IDA] positive regulation of gene expression [IMP] positive regulation of protein amino acid phosphorylation [IDA][IMP] positive regulation of synaptic transmission, cholinergic [IMP] long-term synaptic potentiation [IMP] cellular response to protein stimulus [IEP] response to electrical stimulus [IMP] positive regulation of peptidyl-tyrosine phosphorylation [IDA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein kinase binding [IPI] protein tyrosine kinase activity [IDA] protein binding [UNKNOWN][IEA][IPI] transmembrane receptor protein tyrosine kinase activity [IEA] receptor activity [IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS  60
   61 WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 120
  121 PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSA LRENSRIAVL ESGSLRIHNV 180
  181 QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGMPV 240
  241 PTISWIENGN AVSSGSIQEN VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 300
  301 VSIAEWSKSQ KESKGYCAQY RGEVCDAVLV KDSLVFFNTS YPDPEEAQEL LIHTAWNELK 360
  361 AVSPLCRPAA EALLCNHLFQ ECSPGVLPTP MPICREYCLA VKELFCAKEW LAMEGKTHRG 420
  421 LYRSGMHFLP VPECSKLPSM HQDPTACTRL PYLDYKKENI TTFPSITSSK PSVDIPNLPA 480
  481 STSSFAVSPA YSMTVIISIM SCFAVFALLT ITTLYCCRRR REWKNKKRES AAVTLTTLPS 540
  541 ELLLDRLHPN PMYQRMPLLL NPKLLSLEYP RNNIEYVRDI GEGAFGRVFQ ARAPGLLPYE 600
  601 PFTMVAVKML KEEASADMQA DFQREAALMA EFDNPNIVKL LGVCAVGKPM CLLFEYMAYG 660
  661 DLNEFLRSMS PHTVCSLSHS DLSTRARVSS PGPPPLSCAE QLCIARQVAA GMAYLSERKF 720
  721 VHRDLATRNC LVGENMVVKI ADFGLSRNIY SADYYKADGN DAIPIRWMPP ESIFYNRYTT 780
  781 ESDVWAYGVV LWEIFSYGLQ PYYGMAHEEV IYYVRDGNIL ACPENCPLEL YNLMRLCWSK 840
  841 LPADRPSFCS IHRILQRMCE RAEGTVGV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: MUSK_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: