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Protein Overview: PRS8_RAT

General Information:
Name(s) found: PRS8_RAT [Swiss-Prot]
Description(s) found:
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  • gi|49065782|sp|P62198.1|PRS8_RAT RecName: Full=26S protease regulatory subunit 8; AltName: Full=Proteasome 26S subunit ATPase 5; AltName: Full=Proteasome subunit p45; AltName: Full=p45/SUG; AltName: Full=Thyroid hormone receptor-interacting protein 1; Sho [NCBI NR]
  • gi|37231718|gb|AAH58462.1| Proteasome (prosome, macropain) 26S subunit, ATPase, 5 [Rattus norvegicus] [NCBI NR]
  • gi|2564003|dbj|BAA22933.1| proteasome p45/SUG [Rattus norvegicus] [NCBI NR]
  • gi|1395177|dbj|BAA11938.1| proteasomal ATPase (rat SUG1) [Rattus norvegicus] [NCBI NR]
  • gi|13592141|ref|NP_112411.1| for proteasomal ATPase (SUG1) [Rattus norvegicus] [NCBI NR]
  • 26S protease regulatory subunit 8 OS=Rattus norvegicus GN=Psmc5 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-93917378 26S protease regulatory subunit 8 [hmr_yeast5_DM3-1_pombe.fasta]
  • for proteasomal ATPase (SUG1) [HMR_022704-rand.fasta]
  • proteasomal ATPase (SUG1) [071204_hmrz_cont.fasta]
  • protease (prosome, macropain) 26S subunit, ATPase 5 [Mus musculus]gi|47522792|ref|NP_999148.1| Tat-binding protein 10 [Sus scrofa]gi|27806101|ref|NP_776866.1| proteasome (prosome, macropain) 26S subunit, ATPase, 5 [Bos taurus]gi|24497435|ref|NP_002796. [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 26S protease regulatory subunit 8 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031149) for proteasomal ATPase (SUG1) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • 26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor-interacting protein 1) (TRIP1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Protease (prosome, macropain) 26S subunit, ATPase 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • for proteasomal ATPase (SUG1) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • proteasomal ATPase (rat SUG1) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • proteasome p45/SUG [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 26S PROTEASE REGULATORY SUBUNIT 8 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Peptidase (prosome, macropain) 26S subunit, ATPase 5 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Psmc5 26S protease regulatory subunit 8 [rat-ipi-250309-contam.fasta]
  • 26S protease regulatory subunit 8 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • 26S protease regulatory subunit 8 OS=Rattus norvegicus GN=Psmc5 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 406 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][ISS]
    cytoplasm [UNKNOWN][ISS]
    proteasome complex [UNKNOWN][ISS]
    [NOT]nucleolus [UNKNOWN]
    Biological Process: proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][ISS]
    negative regulation of transcription [UNKNOWN][IEA]
    protein catabolic process [IEA]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN]
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [UNKNOWN]
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [UNKNOWN]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN]
    nucleoside-triphosphatase activity [IEA]
    thyrotropin-releasing hormone receptor binding [UNKNOWN][ISS]
    transcription factor binding [UNKNOWN][ISS]
    receptor binding [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN ELNAKVRLLR  60
   61 EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD KNIDINDVTP NCRVALRNDS 120
  121 YTLHKILPNK VDPLVSLMMV EKVPDSTYEM IGGLDKQIKE IKEVIELPVK HPELFEALGI 180
  181 AQPKGVLLYG PPGTGKTLLA RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE 240
  241 HAPSIIFMDE IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI 300
  301 LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK 360
  361 GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..406] PSI-BLAST 74.69897 VCP/p97


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle