Protein Overview: Pten-PA, Pten-PE

General Information:
Name(s) found:	Pten-PA / FBpp0088844 [FlyBase] Pten-PE / FBpp0088840 [FlyBase]
Description(s) found: Found 45 descriptions. SHOW ALL	The gene Pten is referred to in FlyBase by the symbol Dmel\Pten (CG5671, FBgn0026379). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:10256319..10261017. It has the cytological map location 31B1. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence for 23 unique biological process</span> terms, many of which group under: anatomical structure development; organelle organization; actin filament-based process; regulation of biological process; cytoskeleton organization; regulation of multicellular organism growth; organ development; cell proliferation; biopolymer modification; cell adhesion; lipid storage; programmed cell death; regulation of developmental process; regulation of anatomical structure size; response to nutrient levels; gland morphogenesis; catabolic process; cellular process; response to hormone stimulus. 36 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: external compound sense organ; organ system; peripheral nervous system; nervous system; endocrine system; thoracic segment; imaginal precursor; compound cell cluster organ; embryonic/larval fat body; rhabdomere; cell cycle; dorsal thoracic disc; adult segment. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase] The gene Pten is referred to in FlyBase by the symbol Dmel\Pten (CG5671, FBgn0026379). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:10256319..10261017. It has the cytological map location 31B1. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence for 23 unique biological process</span> terms, many of which group under: anatomical structure development; organelle organization; actin filament-based process; regulation of biological process; cytoskeleton organization; regulation of multicellular organism growth; organ development; cell proliferation; biopolymer modification; cell adhesion; lipid storage; programmed cell death; regulation of developmental process; regulation of anatomical structure size; response to nutrient levels; gland morphogenesis; catabolic process; cellular process; response to hormone stimulus. 36 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: external compound sense organ; organ system; peripheral nervous system; nervous system; endocrine system; thoracic segment; imaginal precursor; compound cell cluster organ; embryonic/larval fat body; rhabdomere; cell cycle; dorsal thoracic disc; adult segment. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	509 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	cell proliferation [IMP] regulation of cell shape [IMP] negative regulation of growth [TAS] negative regulation of multicellular organism growth [IMP] regulation of multicellular organism growth [IMP][NAS] lipid storage [IMP] cytoskeleton organization [IMP] insulin receptor signaling pathway [IGI][NAS] negative regulation of cell proliferation [IEA] regulation of cell size [IMP][NAS] response to starvation [IMP] negative regulation of cell cycle [TAS] actin filament organization [IMP] cell adhesion [IMP] larval development [IMP] metamorphosis [IMP] larval salivary gland morphogenesis [IMP] inositol phosphate dephosphorylation [IEA] phosphoinositide dephosphorylation [IEA][NAS][TAS] regulation of dendrite development [IMP] negative regulation of cell growth [NAS] autophagy [IMP] apoptosis [IMP][TAS] negative regulation of cell size [TAS] protein amino acid dephosphorylation [IMP][ISS][NAS] regulation of organ growth [NAS] negative regulation of organ growth [NAS][TAS] epithelial cell fate determination, open tracheal system [IMP] negative regulation of insulin receptor signaling pathway [NAS][TAS] tissue development [IMP] cellular process [IMP] organ morphogenesis [IMP] negative regulation of focal adhesion assembly [IEA] regulation of protein stability [IEA] lipid metabolic process [IMP] actin cytoskeleton organization [IMP] negative regulation of cell migration [IEA] negative regulation of protein kinase B signaling cascade [IEA]
Molecular Function:	magnesium ion binding [IEA] protein serine/threonine phosphatase activity [IMP] phosphoprotein phosphatase activity [IMP][ISS] non-membrane spanning protein tyrosine phosphatase activity [ISS] actin binding [ISS] protein tyrosine phosphatase activity [ISS] PDZ domain binding [IEA] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IEA] protein tyrosine/serine/threonine phosphatase activity [IEA][ISS][NAS] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IGI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANTISLMSN VIRNVVSKKR IRYKEKGYDL DLTYINDNII AMGYPAPDKL EGLFRNRLED  60
   61 VFKLLEENHA QHYKIYNLCS ERSYDVAKFR GRVAVYPFDD HNPPTIELIQ RFCSDVDMWL 120
  121 KEDSSNVVAV HCKAGKGRTG TMICAYLVFS GIKKSADEAL AWYDEKRTKD RKGVTIPSQR 180
  181 RYVQYFSKLV CSSVPYSKVS LNVCEIRFSE SSCVQNLGMV ECSISVLHDS ATENAKPDRL 240
  241 KTLPIDFQKS FVLTIKPSIP VSGDVKFELT KKSPDKIICH FWLNTFFVRN YSPCESDGTV 300
  301 NKYIHTLSKS EIDDVHKDSE HKRFSEEFKI SIVFEAENFS NDVQAEASEK ERNENVLNFE 360
  361 RSDYDSLSPN CYAEKKVLTA IVNDNTTKSQ TIETLDHKDI VTKIQYDTST NSKNTSTACK 420
  421 RKQPNSKTLL PSLNDSTKEE IKRNHIFNQP SIKKTDLIKW QNSEVHITSD TRSINENKNI 480
  481 NYNSYITCKQ SSPKFNCGTE DGEEDWESE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Pten-PA, Pten-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: