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Protein Overview: tup-PB

General Information:
Name(s) found: tup-PB / FBpp0080662 [FlyBase]
Description(s) found:
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  • gi|5052638|gb|AAD38649.1|AF145674_1 tailup [Drosophila melanogaster] [NCBI NR]
  • gi|22946785|gb|AAN11018.1| tailup, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|17136566|ref|NP_476774.1| tailup, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene tailup is referred to in FlyBase by the symbol Dmel\tup (CG10619, FBgn0003896). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:18859500..18881256. It has the cytological map location 37B1. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; notum cell fate specification; motor axon guidance; dorsal closure; terminal region determination; amnioserosa maintenance; germ-band shortening; bristle morphogenesis. 19 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: adult segment; adult mesothoracic segment; appendage segment; cephalopharyngeal skeleton; organ system; pharyngeal sclerite; extended germ band embryo; late extended germ band embryo; peripheral nervous system; extraembryonic structure; metatarsus; unguis. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG10619-PB translation from_gene[CG10619 tup FBgn0003896] seq_release:3 mol_weight=51799 cds_boundaries:(2L:18,839,043..18,858,878[-]) aa_length:465 transcript_info:[CG10619-RB seq_release:3] gene_info:[gene symbol:tup FBgn0003896 gene_boundaries:(2L: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9Y0Z9) TAILUP (CG10619-PB) [DrosMelano7227.FASTAC.txt]
  • CG10619-PB, isoform B [Drosophila melanogaster]gi|17136566|ref|NP_476774.1| CG10619-PB [Drosophila melanogaster]gi|5052638|gb|AAD38649.1| tailup [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:complement(18860957..18861205,18861682..18861897,18861956..18862118,18862180..18862300,18864095..18864283,18864393..18864523,18865470..18865659,18880657..18880795); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=F [fly-100309-contam.fasta]
  • tailup [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10619-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • tailup CG10619-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:complement(18860957..18861205,18861682..18861897,18861956..18862118,18862180..18862300,18864095..18864283,18864393..18864523,18865470..18865659,18880657..18880795); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:complement(18860957..18861205,18861682..18861897,18861956..18862118,18862180..18862300,18864095..18864283,18864393..18864523,18865470..18865659,18880657..18880795); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Tailup OS=Drosophila melanogaster GN=tup PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2L:complement(18860957..18861205,18861682..18861897,18861956..18862118,18862180..18862300,18864095..18864283,18864393..18864523,18865470..18865659,18880657..18880795); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018,FlyMine:FBpp0080662,modMine:FBpp0080662; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:complement(join(18880657..18880795,18865470..18865659,18864393..18864523,18864095..18864283,18862180..18862300,18861956..18862118,18861682..18861897,18860957..18861205)); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018,FlyMine:FBpp0080662,modMine:FBpp0080662; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:complement(join(18880657..18880795,18865470..18865659,18864393..18864523,18864095..18864283,18862180..18862300,18861956..18862118,18861682..18861897,18860957..18861205)); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018,FlyMine:FBpp0080662,modMine:FBpp0080662; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9VJ37, Tailup OS=Drosophila melanogaster GN=tup PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0080662 type=protein; loc=2L:complement(join(18880657..18880795,18865470..18865659,18864393..18864523,18864095..18864283,18862180..18862300,18861956..18862118,18861682..18861897,18860957..18861205)); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018,FlyMine:FBpp0080662,modMine:FBpp0080662; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:complement(join(18880657..18880795,18865470..18865659,18864393..18864523,18864095..18864283,18862180..18862300,18861956..18862118,18861682..18861897,18860957..18861205)); ID=FBpp0080662; name=tup-PB; parent=FBgn0003896,FBtr0081112; dbxref=FlyBase:FBpp0080662,FlyBase_Annotation_IDs:CG10619-PB,GB_protein:AAN11018.1,REFSEQ:NP_476774,GB_protein:AAN11018,UniProt/TrEMBL:Q9Y0Z9,FlyMine:FBpp0080662,modMine:FBpp0080662; MD5=5c81efd0e7114c8fcacfdf78eb63c8a8; length=465; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 465 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: dorsal closure [IMP][TAS]
    torso signaling pathway [IGI]
    notum cell fate specification [IMP]
    germ-band shortening [IMP][TAS]
    terminal region determination [IGI]
    motor axon guidance [IMP]
    head involution [NAS]
    nervous system development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    amnioserosa maintenance [IMP][TAS]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [NAS]
    bristle morphogenesis [IMP]
    Molecular Function: transcription factor activity [IEA]
    zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVMAEIGGHL AHQLPLHNHN HNQTGLQPSL VMNHHLDLDC HGHDVIKKQR LSHCVGCGGQ  60
   61 IHDQYILRVA PDLEWHAACL KCQECRQFLD ESCTCFVRDG KTYCKRDYVR LFGTKCDKCG 120
  121 NSFSKNDFVM RAKTKIFHIE CFRCSACARQ LLPGDEFALR DAGALYCKED HDVLEKSSQS 180
  181 SLTSSSVESN NNISSSNNNN TNLSNNNHSS ELGSMSDSGS ESGSHKSIRD KRPSGPSDGK 240
  241 PTRVRTVLNE KQLHTLRTCY NANPRPDALM KEQLVEMTSL SPRVIRVWFQ NKRCKDKKKT 300
  301 IQMKLQMQQE KEGRKLGYGA MQGIPMIASS PVRHDSPLNL QGLDVQTYQP PWKALSDFAL 360
  361 HADLDSNGAI NTHTPAFQQL VNQMHGYDLN GMPILPPHPH SHPAQGPPHQ HPPPPGGPHN 420
  421 HQNQQPNQQP GGSSLDSGIT SHHHPDSTDS YVTYLESDDS MQGSP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle