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Protein Overview: Updo-PA

General Information:
Name(s) found: Updo-PA / FBpp0087607 [FlyBase]
Description(s) found:
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  • gi|8928075|sp|Q9V595.1|DCUP_DROME RecName: Full=Uroporphyrinogen decarboxylase; Short=URO-D; Short=UPD [NCBI NR]
  • gi|7303877|gb|AAF58922.1| updo, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|201066011|gb|ACH92415.1| FI07665p [Drosophila melanogaster] [NCBI NR]
  • gi|19921920|ref|NP_610501.1| updo, isoform A [Drosophila melanogaster] [NCBI NR]
  • Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 [Swiss-Prot]
  • The gene Updo is referred to in FlyBase by the symbol Dmel\Updo (CG1818, FBgn0033428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5472172..5473623. It has the cytological map location 45F5. Based on sequence similarity, it is predicted to have molecular function</span>: uroporphyrinogen decarboxylase activity. It is reported to be involved in the biological process</span>: heme biosynthetic process; porphyrin biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG1818-PA translation from_gene[CG1818 Updo FBgn0033428] seq_release:3 mol_weight=39989 cds_boundaries:(2R:4,645,419..4,646,671[+]) aa_length:356 transcript_info:[CG1818-RA seq_release:3] gene_info:[gene symbol:Updo FBgn0033428 gene_boundaries:(2R:4,6 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V595) Uroporphyrinogen decarboxylase (EC 4.1.1.37) (URO-D) (UPD) [DrosMelano7227.FASTAC.txt]
  • (AE003833) Updo gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1818-PA [Drosophila melanogaster]gi|19921920|ref|NP_610501.1| CG1818-PA [Drosophila melanogaster]gi|8928075|sp|Q9V595|DCUP_DROME Uroporphyrinogen decarboxylase (URO-D) (UPD) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(5472292..5472306,5472433..5473176,5473236..5473547); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF5 [fly-100309-contam.fasta]
  • Uroporphyrinogen decarboxylase (URO-D) (UPD) [nr-271106-contam.fasta]
  • Updo CG1818-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1818-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(5472292..5472306,5472433..5473176,5473236..5473547); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(5472292..5472306,5472433..5473176,5473236..5473547); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • Uroporphyrinogen decarboxylase OS=Drosophila melanogaster PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(5472292..5472306,5472433..5473176,5473236..5473547); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922,FlyMine:FBpp0087607,modMine:FBpp0087607; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(9584787..9584801,9584928..9585671,9585731..9586042); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922,FlyMine:FBpp0087607,modMine:FBpp0087607; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(9584787..9584801,9584928..9585671,9585731..9586042); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922,FlyMine:FBpp0087607,modMine:FBpp0087607; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087607 type=protein; loc=2R:join(9584787..9584801,9584928..9585671,9585731..9586042); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922,FlyMine:FBpp0087607,modMine:FBpp0087607; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(9584787..9584801,9584928..9585671,9585731..9586042); ID=FBpp0087607; name=Updo-PA; parent=FBgn0033428,FBtr0088524; dbxref=GB_protein:AAF58922.1,FlyBase:FBpp0087607,FlyBase_Annotation_IDs:CG1818-PA,REFSEQ:NP_610501,GB_protein:AAF58922,UniProt/Swiss-Prot:Q9V595,FlyMine:FBpp0087607,modMine:FBpp0087607; MD5=bd440b9f75ff418a1ac282fa6345bfda; length=356; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 356 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: porphyrin biosynthetic process [IEA][NAS]
    heme biosynthetic process [NAS]
    Molecular Function: uroporphyrinogen decarboxylase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDAKPFPVL KNDNLLRAAR GEVVDRVPVW VMRQAGRYLP EFQELRKHHD FFTVCRTPEL  60
   61 ACEVTMQPLR RFDLDASIIF SDILVIPQAL GLTVEMHAGV GPVLPQPIVV PEDLKRLTPD 120
  121 GALSRLSYVG DAITMMRHKL EGRVPLIGFT GAPWTLMGYM IEGGGSKTMS KAKAWLNEHP 180
  181 EDSKLFLNLL TDAIVDYLEM QVKAGAQMLQ VFESSAEHLS KEQFLQWCVP YLKRIRDELV 240
  241 DRLTKKAIPV VPMTLFAKGA GHSLKEQSEL GYDVIGLDWT VDPLEARNLV GPNITLQGNL 300
  301 DPQDMYRDPD ELRNLTTEMV HKFGKSRYIA NLGHGITPQT PITSMEVLVE AVHKAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..356] PSI-BLAST 129.0 Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uroporphyrinogen decarboxylase activity
    		•  4.48282084722609 bayes_pls_golite062009
  • catalytic activity
    		•  2.37862248560593 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.67493268854029 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.54242506764415 bayes_pls_golite062009
  • binding
    		•  1.19577203030346 bayes_pls_golite062009
  • transferase activity
    		•  1.11861612545715 bayes_pls_golite062009
  • protein binding
    		•  0.30230496242508 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle