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Protein Overview: sca-PB, sca-PA

General Information:
Name(s) found: sca-PB / FBpp0086969 [FlyBase]
sca-PA / FBpp0086968 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene scabrous is referred to in FlyBase by the symbol Dmel\sca (CG17579, FBgn0003326). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8668049..8689515. It has the cytological map location 49C3-49D3. It is reported to have molecular function</span>: signal transducer activity. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; compound eye development; imaginal disc-derived wing margin morphogenesis; nervous system development; ommatidial rotation; bristle morphogenesis. 71 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: peripheral nervous system; nervous system; adult segment; organ system; external compound sense organ; adult mesothoracic segment; plasma membrane part; plasma membrane; eo support cell; compound cell cluster organ; embryonic nervous system; acrostichal bristle; imaginal precursor; adult cuticle; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene scabrous is referred to in FlyBase by the symbol Dmel\sca (CG17579, FBgn0003326). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8668049..8689515. It has the cytological map location 49C3-49D3. It is reported to have molecular function</span>: signal transducer activity. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; compound eye development; imaginal disc-derived wing margin morphogenesis; nervous system development; ommatidial rotation; bristle morphogenesis. 71 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: peripheral nervous system; nervous system; adult segment; organ system; external compound sense organ; adult mesothoracic segment; plasma membrane part; plasma membrane; eo support cell; compound cell cluster organ; embryonic nervous system; acrostichal bristle; imaginal precursor; adult cuticle; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 799 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [NAS]
    fibrinogen complex [ISS]
    Biological Process: bristle morphogenesis [IMP]
    ommatidial rotation [IMP]
    signal transduction [IEA]
    lateral inhibition [NAS]
    R8 cell fate commitment [TAS]
    nervous system development [IGI][NAS]
    regulation of R8 cell spacing in compound eye [NAS][TAS]
    imaginal disc-derived wing margin morphogenesis [IMP]
    female meiosis chromosome segregation [IMP]
    compound eye development [IGI][IMP]
    Molecular Function: signal transducer activity [TAS]
    receptor binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRDWQTFPDL QKKKVSRDHL NCPATMAGSN VLWPILLAVV LLQISVAFVS GAASGGVVLS  60
   61 DVNNMLRDAK VVTSEKPVVH SKQETEAPES SVELLRFVDD DEDSEDISSI ERQDGRTMES 120
  121 KKMADQVRLL TKQLNALMLR RREDYEMLEH NLRKSLRLTT NANSVDADMR SELNQLREEL 180
  181 AALRSSQSGN KERLTVEWLQ QTISEIRKQL VDLQRTASNV AQDVQQRSST FEDLATIRSD 240
  241 YQQLKLDLAA QRERQQQTEV YVQELREEML QQEQDFQHAL VKLQQRTRKD GSSASVEEES 300
  301 GSQEANQEQT GLETTADHKR RHCRFQSEQI HQLQLAQRNL RRQVNGLRFH HIDERVRSIE 360
  361 VEQHRIANAN FNLSSQIASL DKLHTSMLEL LEDVEGLQTK MDKSIPELRH EISKLEFANA 420
  421 QITSEQSLIR EEGTNAARSL QAMAVSVSVL QEEREGMRKL SANVDQLRTN VDRLQSLVND 480
  481 EMKNKLTHLN KPHKRPHHQN VQAQMPQDDS PIDSVLAETL VSELENVETQ YEAIINKLPH 540
  541 DCSEVHTQTD GLHLIAPAGQ RHPLMTHCTA DGWTTVQRRF DGSADFNRSW ADYAQGFGAP 600
  601 GGEFWIGNEQ LHHLTLDNCS RLQVQMQDIY DNVWVAEYKR FYISSRADGY RLHIAEYSGN 660
  661 ASDALNYQQG MQFSAIDDDR DISQTHCAAN YEGGWWFSHC QHANLNGRYN LGLTWFDAAR 720
  721 NEWIAVKSSR MLVKRLPAVE CQANASASGA FVSVSGSAAD AAPSSGATTT TTTATAAPAT 780
  781 VTTPKTNNSV VQFVAAGQA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..401] PSI-BLAST 31.0 Heavy meromyosin subfragment
    2 View Details [402..799] PSI-BLAST 61.221849 Fibrinogen


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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