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Protein Overview: Mical-PB

General Information:
Name(s) found: Mical-PB / FBpp0081685 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 3002 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    cytosol [NAS]
    plasma membrane [IDA]
    Biological Process: sarcomere organization [IMP]
    axon guidance [IMP][TAS]
    neuron remodeling [IGI][IMP]
    dendrite morphogenesis [IGI][IMP]
    Molecular Function: zinc ion binding [IEA]
    actin binding [ISS]
    oxidoreductase activity [IEA]
    electron carrier activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQHQRHHQ QHHHLPPHQQ PQQQMPQQQQ QLTAQQQQQQ QLLMAEHAAA AEAAELFDLL  60
   61 CVATTMRQIL ALHRAMCEAV GLRPSPLNDF YPRLKAKVRS WKAQALWKKF DARAAHRVYG 120
  121 KGAACTGTRV LVIGAGPCGL RTAIEAQLLG AKVVVLEKRD RITRNNVLHL WPFVITDLRN 180
  181 LGAKKFYGKF CAGSIDHISI RQLQCMLLKV ALLLGVEIHE GVSFDHAVEP SGDGGGWRAA 240
  241 VTPADHPVSH YEFDVLIGAD GKRNMLDFRR KEFRGKLAIA ITANFINKKT EAEAKVEEIS 300
  301 GVAFIFNQAF FKELYGKTGI DLENIVYYKD ETHYFVMTAK KHSLIDKGVI IEDMADPGEL 360
  361 LAPANVDTQK LHDYAREAAE FSTQYQMPNL EFAVNHYGKP DVAMFDFTSM FAAEMSCRVI 420
  421 VRKGARLMQC LVGDSLLEPF WPTGSGCARG FLSSMDAAYA IKLWSNPQNS TLGVLAQRES 480
  481 IYRLLNQTTP DTLQRDISAY TVDPATRYPN LNRESVNSWQ VKHLVDTDDP SILEQTFMDT 540
  541 HALQTPHLDT PGRRKRRSGD LLPQGATLLR WISAQLHSYQ FIPELKEASD VFRNGRVLCA 600
  601 LINRYRPDLI DYAATKDMSP VECNELSFAV LERELHIDRV MSAKQSLDLT ELESRIWLNY 660
  661 LDQICDLFRG EIPHIKHPKM DFSDLRQKYR INHTHAQPDF SKLLATKPKA KSPMQDAVDI 720
  721 PTTVQRRSVL EEERAKRQRR HEQLLNIGGG AAGAAAGVAG SGTGTTTQGQ NDTPRRSKKR 780
  781 RQVDKTANIE ERQQRLQEIE ENRQERMSKR RQQRYHQTQN FYKSLQLLQA GKLLREGGEA 840
  841 GVAEDGTPFE DYSIFLYRQQ APVFNDRVKD LERKLLFPDR ERGDIPSALP RTADEQFSDR 900
  901 IKNMEQRMTG RGGLGGDKKP KDLMRAIGKI DSNDWNVREI EKKIELSKKT EIHGPKGREK 960
  961 VPKWSKEQFQ ARQHKMSKPQ RQDSREAEKF KDIDQTIRNL DKQLKEGHNL DVGERGRNKV1020
 1021 ASIAGQFGKK DEANSDEKNA GSSNATTNTN NTVIPKSSSK VALAFKKQAA SEKCRFCKQT1080
 1081 VYLMEKTTVE GLVLHRNCLK CHHCHTNLRL GGYAFDRDDP QGRFYCTQHF RLPPKPLPQR1140
 1141 TNKARKSAAA QPASPAVPPT AGSVPTAAAT SEHMDTTPPR DQVDLLETSR ANASADAMSD1200
 1201 DEANVIDEHE WSGRNFLPES NNDSQSELSS SDESDTESDS EMFEEADDSP FGAQTLQLAS1260
 1261 DWIGKQYCED SDDSDDFYDS SEGIADDGKD DTEGEEFKKA RELRRQEVRL QPLPANLPTD1320
 1321 TETEVQTESE STSPDEVELN SATEISTDSE FDNDEIIRQA PKIFIDDTHL RKPTKVQIKS1380
 1381 TMIGPNAASA GLHQKQLAAR EKGGSYLQKY QPQPPLPQFK PLVQVDPTLL IGSQRAPLQN1440
 1441 PRPGDYLLNK TASTEGIASK KSLELKKRYL LGEPANGNKI QKSGSTSVLD SRIRSFQSNI1500
 1501 SECQKLLNPS SDISAGMRTF LDRTKLGEGS QTTPGQTNEL IRSATSNVIN DLRVELRIQK1560
 1561 TGSSHSTDNE KENVFVNCKN ELNKGMEYTD AVNATLLDQL ARKSSPTTPT NKTVVEVIDL1620
 1621 VTPEKPIDII DLTALETPKK QLVDGSAMDV DERLTPDSNK ISELQQEVKE EPKPDVSRDV1680
 1681 KECIPDILGH IKEGTGSKEP GGEDQQSLLE QSDEEKRDSP EKDVAEHELY EPDSVQIQVP1740
 1741 NIPWEKSKPE VMSTTGSSGS ICSSSDSSSI EDIQHYILES TTSPDTQTVG GKHNVPRLEV1800
 1801 HDTSGALMQV DSLMIVNGKY IGDPEDVKFL DMPANVIVPP APALKTNELD MEDDQEAEAE1860
 1861 PVTATPEPVE CTVIEAERRV TAPPPLPEMG PPKLKFDSKN ENKIESLKNL PLIVESNVEH1920
 1921 SQAVKPITLN LSNLARTPDT PTTPTAHDSD KTPTGEILSR GSDSETEHTG TGQVLTETEL1980
 1981 SDWTADDCIS ENFVDLEFAL NSNKGTIKRR KDRRRSGASK LPSGNEVIHE LARQAPVVQM2040
 2041 DGILSAIDID DIEFMDTGSE GSCAEAYSAT NTALIQNRGY MEYIEAEPKK TTRKAAPPSS2100
 2101 YPGNLPPLMT KRDEKLGVDY IEQGAYIMHD DAKTPVNEVA PAMTQSLTDS ITLNELDDDS2160
 2161 MIISQTQPTT TEESEALTVV TSPLDTSSPR VLDQFASMLA AGKGDSTPSS SEQQPKTSTV2220
 2221 TSSSTGPNSS TTGNVSKEPQ EEDLQIQFEY VRALQQRISQ ISTQRRKSSK GEAPNLQLNS2280
 2281 SAPVIESAED PAKPAEEPLV SMRPRTTSIS GKVPEIPTLS SKLEEITKER TKQKDLIHDL2340
 2341 VMDKLQSKKQ LNAEKRLHRS RQRSLLTSGY ASGSSLSPTP KLAAACSPQD SNCSSQAHYH2400
 2401 ASTAEEAPKP PAERPLQKSA TSTYVSPYRT VQAPTRSADL YKPRPFSEHI DSNALAGYKL2460
 2461 GKTASFNGGK LGDFAKPIAP ARVNRGGGVA TADIANISAS TENLRSEARA RARLKSNTEL2520
 2521 GLSPEEKMQL IRSRLHYDQN RSLKPKQLEE MPSGDLAARA RKMSASKSVN DLAYMVGQQQ2580
 2581 QQQVEKDAVL QAKAADFTSD PNLASGGQEK AGKTKSGRRP KDPERRKSLI QSLSSFFQKG2640
 2641 SGSAASSSKE QGGAVAAVHS EQSERPGTSS SGTPTISDAA GGGGGGGGVF SRFRISPKSK2700
 2701 EKSKSCFDLR NFGFGDKDML VCNAASPAGA TSASQKNHSQ EYLNTTNNSR YRKQTNTAKP2760
 2761 KPESFSSSSP QLYIHKPHHL AAAHPSALDD QTPPPIPPLP LNYQRSDDES YANETREHKK2820
 2821 QRAISKASRQ AELKRLRIAQ EIQREQEEIE VQLKDLEARG VLIEKALRGE AQNIENLDAT2880
 2881 KDNDEKLLKE LLEIWRNITA LKKRDEELTI RQQELQLEYR HAQLKEELNL RLSCNKLDKS2940
 2941 SADVAAEGAI LNEMLEIVAK RAALRPTASQ LDLTAAGSAS TSAEATGIKL TGQPHDHEES3000
 3001 II

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle