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Protein Overview: hth-PB

General Information:
Name(s) found: hth-PB / FBpp0081731 [FlyBase]
Description(s) found:
Found 14 descriptions.
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  • The gene homothorax is referred to in FlyBase by the symbol Dmel\hth (CG17117, FBgn0001235). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6335569..6464386. It has the cytological map location 86C1-86C3. There is experimental evidence that it has the molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; compound eye development; specification of segmental identity, antennal segment; specification of segmental identity, head; segmentation; compound eye photoreceptor fate commitment; brain development; imaginal disc-derived wing morphogenesis; haltere morphogenesis; imaginal disc-derived leg morphogenesis. 63 alleles are reported. The phenotypes of these alleles are annotated with 63 unique terms, many of which group under: adult segment; peripheral nervous system; nervous system; thoracic segment; external compound sense organ; appendage segment; organ system; adult mesothoracic segment; embryonic segment; embryonic nervous system. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 471 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPRYDDGL HGYGMDSGAA AAAMYDPHAG HRPPGLQGLP SHHSPHMTHA AAAAATVGMH  60
   61 GYHSGAGGHG TPSHVSPVGN HLMGAIPEVH KRDKDAIYEH PLFPLLALIF EKCELATCTP 120
  121 REPGVQGGDV CSSESFNEDI AMFSKQIRSQ KPYYTADPEV DSLMVQAIQV LRFHLLELEK 180
  181 VHELCDNFCH RYISCLKGKM PIDLVIDERD TTKPPELGSA NGEGRSNADS TSHTDGASTP 240
  241 DVRPPSSSLS YGGAMNDDAR SPGAGSTPGP LSQQPPALDT SDPGRWCRRE WSSPADARNA 300
  301 DASRRLYSSV FLGSPDNFGT SASGDASNAS IGSGEGTGEE DDDASGKKNQ KKRGIFPKVA 360
  361 TNILRAWLFQ HLTHPYPSED QKKQLAQDTG LTILQVNNWF INARRRIVQP MIDQSNRAVY 420
  421 TPHPGPSGYG HDAMGYMMDS QAHMMHRPPG DPGFHQGYPH YPPAEYYGQH L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..243] MSA 4.763982 View MSA. No confident structure predictions are available.
    3 View Details [244..342] deduced N/A No confident structure predictions are available.
    4 View Details [343..471] PSI-BLAST 11.69897 Solution structure of the homeobox domain of human homeobox protein PKNOX1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • serum response element binding
    		•  0.32349914936049 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.0943601066056998 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.0802156998596484 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle